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Intracellular membrane fusion is coordinated by membrane-anchored fusion proteins. The cytosolic domains of these proteins form a specific complex that pulls the membranes into close proximity. Although some results indicate that membrane merger can be accomplished solely on the basis of proximity, others emphasize the importance of bilayer stress exerted by transmembrane peptides. In a reductioni

Psoriasis is a complex genetic disease of unresolved pathogenesis with both heritable and environmental factors contributing to onset and severity. In addition to a disfiguring skin inflammation, approximately 10-40% of psoriasis patients suffer from destructive joint involvement. Previously, we reported that the CD18 hypomorphic PL/J mouse carrying a mutation resulting in reduced expression of th

User-centred design approaches within the field of furniture design for old people involves an act of embracing and balancing various end-user needs and assessing their relative importance for the product experience. It is often assumed that older people’s physiological needs dominate their other needs. In the present study, three focus group interviews were carried out with the exploratory purpos

Föreliggande studie har undersökt implementering av terapeuters erhållna kunskaper efter att ha genomgått vidareutbildning i biologisk traumabehandling, som är en utbildning för behandling av trauma med utgångspunkt i kroppen. Två frågeställningar har studerats: 1) Vilket kunskapsinnehåll och vilka kunskapsformer står i fokus när terapeuterna reflekterar över sin praktik i biologisk traumabehandliThe purpose of this study is to examine the implementation of knowledge acquired by therapists after having taking part in a further education course of biological trauma treatment, which aimed at using the body as a starting point for trauma treatment. Two issues have been studied: 1)What content of knowledge and what forms of knowledge have the therapists reflected about in their practice of bio

Issue: Does a statistical relationship between OMXS30 and S&P500 plus OMXS30 and DAX30 exist after extreme returns? Is it possible to explain the relationship between OMXS30 and S&P500 plus S&P500 and DAX30 with the chosen economic theories? Purpose: The purpose is to examine the effects on OMXS30 during 6 days after extreme returns on S&P500 or DAX30 are present. These effects wi

Neutralitetskonceptet växte fram under en tid då konflikter mellan länder fortfarande var en regional angelägenhet. Idag har kollektiva säkerhetssystemet i FN-stadgan konverterat dessa konflikter till en global angelägenhet. Syftet med uppsatsen är att undersöka korrelationen mellan neutralitetslagstiftningen och FN-stadgan och hur detta påverkar neutrala stater inom FN. Frågeställningen är i viThe concept of neutrality emerged at a time when conflicts between states were still regional matters. Today the system of collective security within the UN Charter has converted these conflicts into a global issue. The purpose of this essay is to examine the correlation between the law of neutrality and the Charter of the United Nations and how this affects the neutral member states of the Unit

ABSTRACT Key words: Axiology, Value of Exchange, Blue Ocean Strategy, Docking Equipment, Key Value Factor, Value Co-Creation, The STACC Value Model Issue of Study: In a typical red ocean - an industry with shrinking margins, overcapacity and decreasing demand - Crawford Solutions has the ambition to become what they call a solution provider. The question arises whether there is a potential for val

Purpose: People with acquired neurogenic Communication Disorders (PwCD) experience reduced satisfaction in healthcare environments, possibly relating to communication difficulties. Communication Partner Training might improve communication success. The purpose of the scoping review was to map the literature about educational experiences in teaching communication strategies to healthcare students (

The article contributes to the research of platformisation of everyday life and children’s television use by exploring how 0-3-year-olds’ television viewing on screen media is embedded in daily social practices of families in Sweden. The article examines the research questions: 1) What social practices are organised around young children’s television viewing on screen media? 2) How can these telev

Abstract The purpose of the study is to examine if the use of state aid in the EU have increased or decreased and especially the use of state aid to support the manufacturing sector. The development of total state aid in relation to GDP and sectoral distribution of total aid are studied. So is state aid to the manufacturing sector and its different objectives and forms, since this sector is grante

The Kaposi's, sarcoma-associated herpesvirus (KSHV) complement control protein (KCP) inhibits the human complement system, and is similar in structure and function to endogenous complement inhibitors. Other inhibitors such as C4d-binding protein and factor H, as well as the viral homologue vaccinia virus complement control protein are known to bind heparin and, for the two latter, also to glycosam

The titration properties of a fatty acid solubilized in different types of micelles, cationic, anionic and nonionic, have been investigated experimentally and theoretically. The solution containing micelles, counterions, and added salt was treated as a dielectric continuum in the Monte Carlo simulations. The dielectric permittivity of the interior of the micelle can have a profound effect on the c

Tumor cells secreting IL-1 beta are invasive and metastatic, more than the parental line or control mock-transfected cells, and concomitantly induce in mice general immune suppression of T cell responses. Suppression strongly correlates with accumulation in the peripheral blood and spleen of CD11b(+)/Gr-1(+) immature myeloid cells and hematological alterations, such as splenomegaly, leukocytosis,

Complement deficiencies are probably vastly under-diagnosed within clinical medicine. Judging from a Swedish study of C2 deficiency, a deficiency with an estimated prevalence of about 1/20,000 in Western countries, less than 10% of the deficiencies of the classical and alternative pathways and the late complement components are identified in Sweden. C1 inhibitor deficiency and deficiencies of MBL