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OBJECTIVES: Atherothrombosis in the carotid arteries is a main cause of ischemic stroke and may depend on plaque propensity to complicate with rupture or erosion, in turn related to vulnerability features amenable to in vivo imaging. This would provide an opportunity for risk stratification and-potentially-local treatment of more vulnerable plaques. We here review current information on this topic
The evaluation of modelling diagnostics with appropriate observations is an important task that establishes the capabilities and reliability of models. In this study we compare aerosol and cloud properties obtained from three different climate models (ECHAM-HAM, ECHAM-HAMSALSA, and NorESM) with satellite observations using Moderate Resolution Imaging Spectroradiometer (MODIS) data. The simulator M
BACKGROUND: -Atrial fibrillatory rate (AFR) is a measure of atrial remodeling caused by atrial fibrillation (AF) and its acceleration negatively affects outcome of interventions for persistent AF. However, the prognostic value of AFR in patients with CHF has not been studied. We sought to evaluate whether AFR can predict outcome in patients with mild to moderate (NYHA II-III) congestive heart fail
Anaerobic bacteria dominate the human normal microbiota but strikingly little is known about these commensals. Finegoldia magna is a Gram-positive anaerobe found in the skin and at other non-sterile body surfaces, but it is also an opportunistic pathogen. This study describes a novel protein designated FAF (F. magnaAdhesion Factor) and expressed by more than ninety percent of F. magna isolates. Th
BACKGROUND: To elucidate the mechanism by which local delivery of 3-morpholino-sydnonimine (SIN-1) affects intimal hyperplasia after percutaneous transluminal coronary angioplasty (PTCA). METHODS: Porcine coronary arteries were treated with PTCA and immediately afterwards locally treated for 5 minutes, with a selective cytosolic guanylate cyclase inhibitor, 1 H-(1,2,4)oxadiazole(4,3-alpha)quinox
We consider the log-likelihood function of hidden Markov models, its derivatives and expectations of these (such as different information functions). We give explicit expressions for these functions and bound them as the size of the chain increases. We apply our bounds to obtain partial second order asymptotics and some qualitative properties of a special model as well as to extend some results
This article extends the common correlated effects pooled (CCEP) estimator to homogenous dynamic panels. In this setting, CCEP suffers from a large bias when the time span (T) of the dataset is fixed. We develop a bias-corrected CCEP estimator that is consistent as the number of cross-sectional units (N) tends to infinity, for T fixed or growing large, provided that the specification is augmented
Despite many reports of putative stem-cell-based treatments in genetic and degenerative disorders or severe injuries, the number of proven stem cell therapies has remained small. In this Review, we survey advances in stem cell research and describe the cell types that are currently being used in the clinic or are close to clinical trials. Finally, we analyse the scientific rationale, experimental
The present study focuses on NNE-trending dykes (sites LDA to LDJ) that occur near Mashishing in the eastern Kaapvaal craton. The Mashishing dykes were previously considered to be coeval and regarded as the extension of the 1.875–1.835Â Ga Black Hills dyke swarm into the sedimentary rocks of the Pretoria Group. Thin sections exhibit well-preserved igneous textures, with primary minerals (e.g., hor
Enzymatic transglycosylation of lactose into oligosaccharides was studied using wild-type β-glucosidase (CelB) and active site mutants thereof (M424K, F426Y, M424K/F426Y) and wild-type β-mannosidase (BmnA) of the hyperthermophilic Pyrococcus furiosus. The effects of the mutations on kinetics, enzyme activity, and substrate specificity were determined. The oligosaccharide synthesis was carried out
BACKGROUND: Clinical Record (CR) writing is a fundamental skill for healthcare professionals, but the best e-learning methods for teaching it remain unstudied. Therefore, we investigated speech therapy students' differences in the quality production of CR at the placement and their experience after following asynchronous or synchronous e-learning courses.METHODS: A multi-method randomised controll
We consider a version of the Erdős–Rothschild problem for families of graph patterns. For any fixed k≥3, let r0(k) be the largest integer such that the following holds for all 2≤r≤r0(k) and all sufficiently large n: The Turán graph Tk−1(n) is the unique n-vertex graph G with the maximum number of r-edge-colorings such that the edge set of any copy of Kk in G is rainbow. We use the regularity lemma
Despite the increased use of different types of gender-fair forms in French, studies investigating their interpretation in context remain few. To fill this gap, we conducted a pre-registered study using a timed sentence evaluation task to examine speakers' possibilities to establish an anaphoric relationship between a gendered anaphoric expression (women or men) and non-stereotyped role nouns as a
We demonstrate for the first time that seeded harmonic generation on electron storage rings can produce coherent optical pulses in the vacuum ultraviolet spectral range. The experiment is performed at Elettra, where coherent pulses are generated at 132nm, with a duration of about 100fs. The light source has a repetition rate of 1kHz and adjustable polarization; it is very bright, with a peak power
