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Role of the galactosyl moiety of collagen glycopeptides for T-cell stimulation in a model for rheumatoid arthritis

Two protected derivatives of beta-D-galactopyranosyl-5-hydroxy-L-lysine, in which HO-4 of galactose has been O-methylated or replaced by fluorine, have been prepared. The building blocks were incorporated at position 264 of the peptide fragment CII259-273 from type II collagen by solid-phase synthesis. The ability of these two glycopeptides, and two CII259-273 glycopeptides in which HO-4 of galact

Type II collagen without adjuvant induces eosinophilic arthritis.

Eosinophilia is a characteristic feature of many inflammatory diseases including inflammatory bowel disease and asthma. It also occurs in a subtype of rheumatoid arthritis but the role of eosinophils has been unclear and animal models have been lacking. Here, we introduce a new mouse model to study the role of eosinophilia in arthritis. Intraperitoneal injection of type II collagen alone, without

Disease-related variations of the glycosylation of haptoglobin in the dog

Haptoglobin phenotypes have been shown in human medicine to be related to the prevalence of various diseases. Furthermore, abnormal glycosylation of haptoglobin has been reported as a consequence of liver disease, cancer and immunological disorders in man. To our knowledge, similar findings have not, so far, been reported in canine disease. The present paper describes a method for investigation of

Immunoblot Analysis as an Alternative Method to Diagnose Enterohepatic Helicobacter Infections

Enterohepatic Helicobacter species have been associated with chronic infections of the hepatobiliary tract and lower bowel in naturally and experimentally infected mice, Helicobacter-infected animals should thus not be used in studies of diseases associated with chronic inflammation. Helicobacter species induce inflammation and modulate host immune responses, thus emphasizing the need to diagnose

Staff experience and understanding of working with abused women suffering from mental illness

The phenomenon of abused women with mental illness is often unrecognised by staff working within welfare services. This may be explained by staff members' attitudes, insecurity or lack of awareness. Today, there are shortcomings in the knowledge of staff members' experiences and interpretations of abuse against women suffering from mental illness. The aim of this qualitative study was to describe

Development of high-grade lymphoma in Helicobacter pylori-infected C57BL/6mice

Helicobacter pylori infection is associated with chronic gastritis, peptic ulcer disease, gastric adenocarcinoma and MALT lymphoma. Mice with H. pylori infection develop severe gastritis and atrophic changes in their stomachs after 6 months. We followed H. pylori -infected animals for 13 months to find out whether dysplasia, carcinoma or lymphoma developed. Six-week-old C57BL/6 mice were infected

Binding of human C4BP to the hypervariable region of M protein: a molecular mechanism of phagocytosis resistance in Streptococcus pyogenes

The amino-terminal hypervariable region (HVR) of streptococcal M protein is required for the ability of this virulence factor to confer phagocytosis resistance. The function of the HVR has remained unknown, but the finding that many HVRs with extremely divergent sequences bind the human complement regulator C4b-binding protein (C4BP) has suggested that this ligand may play a role in phagocytosis r

Lectin histochemistry of the gastric mucosa in normal and Helicobacter pylori infected guinea-pigs

Helicobacter pylori attaches via lectins, carbohydrate binding proteins, to the carbohydrate residues of gastric mucins. Guinea-pigs are a suitable model for a H. pylori infection and thus the carbohydrate composition of normal and H. pylori infected gastric mucosa was investigated by lectin histochemistry. The stomach of all infected animals showed signs of an active chronic gastritis in their mu

The search for a peptide ligand targeting the lipolytic enzyme cutinase

A constrained nonapeptide phage display library was evaluated as a potential source of affinity ligand(s) for purification of cutinase, a lipolytic enzyme. After seven cycles of biopanning, 500 clones were isolated and individually tested for their capability to interact with cutinase. Three out of six sequenced clones carrying a cutinase-specific constrained peptide showed the same insert sequenc

Automated protein identification by the combination of MALDI MS and MS/MS spectra from different instruments

The identification of proteins separated on two-dimensional gels is most commonly performed by trypsin digestion and subsequent matrix-assisted laser desorption ionization (MALDI) with time-of-flight (TOF). Recently, atmospheric pressure (AP) MALDI coupled to an ion trap (IT) has emerged as a convenient method to obtain tandem mass spectra (MS/MS) from samples on MALDI target plates. In the presen

Targeting proteins to secretory lysosomes of natural killer cells as a principle for immunoregulation.

Secretory lysosomes of natural killer (NK) cells combine storage, regulated secretion and lysosomal activity. We asked whether one could target exogenous proteins to the secretory lysosomes of NK-cells for final delivery into a tumor site upon degranulation. cDNAs for both soluble and transmembrane (tm) proteins were expressed in the human YT-Indy NK-cell line. Targeting of a soluble TNF receptor

Relationship of airway responsiveness to agents causing bronchoconstriction and cough in sensitized guinea-pigs

The relationship between airway responsiveness to bronchoconstrictor- and cough-inducing stimuli has been examined in Ascaris suum-sensitized conscious guinea-pigs. Guinea-pigs were sensitized to Ascaris suum [4000 PNU and 100 mg Al(OH)3 i.p. on days 1 and 7] and then challenged with aerosolized antigen on days 21, 28 and 35. At day 35, antigen-exposure produced an early bronchoconstrictor respons

Sakerhets och ordningsregler 0

Ing Sida 1 Säkerhets- och ordningsregler för personal och studerande vid Avdelningen för Medicinsk Strålningsfysik, Kampradhuset och Byggnad 13 Inledning Avd för Medicinsk strålningsfysiks arbetsmiljöpolicy följer den som rektor antagit för Lunds universitet 2010, http://www5.lu.se/regelverket/lunds-universitets-regler/arbetsmiljoe-och-yttre-miljoe/planer-policies-och- maaldokument. Det ligger i a

https://www.msf.lu.se/sites/msf.lu.se/files/sakerhets_och_ordningsregler_0.pdf - 2026-05-03

Mikrofilmade-dagstidningar-2017

Mikrofilmade dagstidningar (UB-Lund) 18 minuter 2009 – 2013 3 dagar 1993 – 1994 8 sidor 1992 – 2012 Aftonbladet 1830 – 2013 Aftontidningen 1909 – 1956 Alingsås Nyheter 1917 – 1920 Alingsås Tidning 1979 – 2013 Allehanda 1881 – 1885 Se även Södertälje Allehanda Allehanda Karlskoga-Degerfors Se: Nerikes Allehanda Alternativet 1988 – 1992 Amerikaposten 1924 – 1925 Anmärckningar Wid Swenska post-tidnin

https://www.ub.lu.se/sites/ub.lu.se/files/mikrofilmade-dagstidningar-2017.pdf - 2026-05-03

Activity report 2019

SASNET Activity Report 2019 SWEDISH SOUTH ASIAN STUDIES NETWORK 2 SASNET ACTIVITY REPORT 2019 3SASNET ACTIVITY REPORT 2019 Table of Contents SASNET ACTIVITY REPORT 2019 5 SEMINARS AND PUBLIC EVENTS 6 WORKSHOPS AND CONFERENCES 8 Symposium on the Indo-Pacific in Singapore 8 South Asia across the Nordic Region (SANR) 2019 8 Workshop on Challenges to Media in South Asia 9 Workshop on Afghanistan: Migr

https://www.sasnet.lu.se/sites/sasnet.lu.se/files/activity_report_2019.pdf - 2026-05-03