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Human soluble (S) and membrane-bound (MB) catechol O-methyltransferase (COMT, EC 2.1.1.6) enzymes have been expressed at sufficiently high levels in Escherichia coil and in baculovirus-infected insect cells to allow kinetic characterization of the enzyme forms. The use of tight-binding inhibitors such as entacapone enabled the estimation of actual enzyme concentrations and, thereby, comparison of

A comparative study was performed to reveal differences and relative figures of merit of seven different calculation algorithms for photon beams when applied to inhomogeneous media. The following algorithms were investigated: Varian Eclipse: the anisotropic analytical algorithm, and the pencil beam with modified Batho correction; Nucletron Helax-TMS: the collapsed cone and the pencil beam with equ

CONTEXT: The tension between service and training in pressured health care environments can have a detrimental impact on training quality and job satisfaction. Yet the management literature proposes that competing demands are inherent in organisational settings: it is not the demands as such that lead to negative outcomes but how people and organisations react to opposing tensions. We explored how

Objective. Heredity is a major cause of ovarian cancer and during recent years the contribution from germline mismatch repair (MMR) gene mutations linked to Lynch syndrome has gradually been recognized. Methods. We characterized clinical features, tumor morphology and mismatch repair defects in all ovarian cancers identified in Swedish and Danish Lynch syndrome families. Results. In total, 63 epit

Comparative analyses of gene birth–death dynamics have the potential to reveal gene families that played an important role in the evolution of morphological, behavioral, or physiological variation. Here, we used whole genomes of 30 species of butterflies and moths to identify gene birth–death dynamics among the Lepidoptera that are associated with specialist or generalist feeding strategies. Our w

Background Anorexia nervosa is associated with high personal and financial costs for sufferers, carers and society in general, but little is known about the long-term health economic burden. Aims To examine healthcare utilisation, social assistance, sick leave and disability pension in individuals with anorexia nervosa over a period of 30 years. Method Fifty-one individuals with adolescent-onset a

Background: Recently developed buprenorphine depot injections have the potential to reduce risk for diversion and misuse, and to increase adherence with fewer visits for supervised intake. However, it is unclear how patients perceive this new form of medication. The purpose of this study was to explore patients experiences of depot injections and their reasons for continuing, discontinuing, or dec

Barnfridsbrottet infördes i svensk rätt år 2021, med ett starkt rättspolitiskt motiverat perspektiv – att skydda och stärka ställningen för barn som tvingades bevittna våld mellan närståendepersoner. Innan bestämmelsen trädde i kraft i svensk lagstiftning fanns det inte något annat skydd. Av den anledningen redogörs detta kort för genom uppsatsen, för att ge läsaren en förståelse om hur bestämmelsThe child protection offense was introduced into Swedish law in 2021, with a strong legal policy perspective - to protect and strengthen the position of children who were forced to witness violence between close persons. Prior to the entry into force of the provision in Swedish law, there was no other protection. For this reason, this is briefly described throughout the paper, to give the reader a

Konstnär l iga fakulteten i Malmö Dnr: U2018/306 Allmän studieplan för utbildning på forskarnivå i musikpedagogik 1. Identifikation Utbildningens namn och inriktning: Utbildning på forskarnivå i musikpedagogik Kod: KOMUPE00 Omfattning i högskolepoäng: 240 Nivå: Forskarnivå Examensbenämning: Filosofie doktorsexamen i musikpedagogik Engelsk examensbenämning: Doctor of Philosophy in Music Education P

https://www.konstnarliga.lu.se/sites/konstnarliga.lu.se/files/allman_studieplan_for_utbildning_pa_forskarniva_i_musikpedagogik_revid_2018_0.pdf - 2026-05-22

BACKGROUND: Hypothermia may be accidental or therapeutic. Therapeutic hypothermia is increasingly used as treatment for various conditions, e.g., neuroprotection after cardiac arrest. Hypothermia leads to an impairment of the coagulation system, but the degree of impairment has been difficult to determine. Most studies have been performed on plasma instead of whole blood. We therefore evaluated wh

Background: Risk gene variants for celiac disease, identified in genome-wide linkage and association studies, might influence molecular pathways important for disease development. The aim was to examine expression levels of potential risk genes close to these variants in the small intestine and peripheral blood and also to test if the non-coding variants affect nearby gene expression levels in chi

Hematopoiesis is initiated by a rare population of hematopoietic stem cells (HSC) in the bone marrow (BM). HSCs give rise to red blood cells and white blood cells of myeloid and lymphoid lineages. The red blood cells are responsible for transporting oxygen throughout the body, while the myeloid and lymphoid cells are essentially required for immune responses. The HSCs reside in special niches in t

The kallikrein gene family (KLK1-KLK15) is the largest contiguous group of protease genes within the human genome and is associated with both risk and outcome of cancer and other diseases. We searched for copy number variants in all KLK genes using quantitative PCR analysis and analysis of inheritance patterns of single nucleotide polymorphisms. Two deletions were identified: one 2235-bp deletion

Results of numerical simulations are presented for flow past a stationary circular cylinder at low Reynolds numbers (Re=50-200). The simulations were carried out using a finite-volume code employing a fractional step method with second-order accuracy in both space and time. A sensitivity study on numerical parameters concerning the domain size, grid independence and time step resolution was carrie

In this work it is shown that domains of ordered dipoles are formed in large droplets made from dipolar particles provided that the dipole-dipole interaction between nearest neighbors is larger than the thermal energy. The size of the domains grows almost linearly with the size of the droplets for droplets containing 1000-30 000 particles. The largest domains occupy around 25-35% of the droplet vo

To enhance the performance of gas turbine engines, high top-cycle temperatures are desired. However, the temperature is limited by current materials. To achieve the higher performance, and meanwhile maintain the metal temperatures of the combustors, vanes and blades below the allowable limits, sophisticated cooling techniques, such as impingement cooling, film cooling and convective internal cooli

In this work, influence of hydrogen and temperature on the fracture toughness parameters of unirradiated, cold worked and stress relieved (CWSR) Zr-2.5Nb pressure tube alloys used in Indian Pressurized Heavy Water Reactor is reported. The fracture toughness tests were carried out using 17 mm width curved compact tension specimens machined from gaseously hydrogen charged tube-sections. Metallograph