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Pulseq-CEST : Towards multi-site multi-vendor compatibility and reproducibility of CEST experiments using an open-source sequence standard

PURPOSE: As the field of CEST grows, various novel preparation periods using different parameters are being introduced. At the same time, large, multisite clinical studies require clearly defined protocols, especially across different vendors. Here, we propose a CEST definition standard using the open Pulseq format for a shareable, simple, and exact definition of CEST protocols.METHODS: We present

Post-socialist moral economies of consumption as socially embedded sites of moral tension

Consumption was one of the spheres of everyday life shaken and remoulded by the collapse of socialist regimes at the end of the 20th century. Especially in times of rapid change, a moral economies lens is a fruitful means to understand the contentious moral landscape and moral tensions that pervade consumption behaviour, norms and discourse. Important areas of consideration in post-socialist socie

A transformation of the Memorial Site in Katyn

In the wake of the deterioration of relations between modern Russia and Poland, the Katyn memorial has become a scene for the contestation of historical memory. In order to play down the 1940 executions of Polish military officers in Katyn, the Russian government has granted belated official recognition to 8,000 victims of Stalinism in the Smolensk region. After being brushed under the carpet in t

AfsK-Mediated Site-Specific Phosphorylation Regulates DnaA Initiator Protein Activity in Streptomyces coelicolor

In all organisms, chromosome replication is regulated mainly at the initiation step. Most of the knowledge about the mechanisms that regulate replication initiation in bacteria has come from studies on rod-shaped bacteria, such as Escherichia coli and Bacillus subtilisStreptomyces is a bacterial genus that is characterized by distinctive features and a complex life cycle that shares some propertie

Contributions of dust and biomass burning to aerosols at a Colorado mountain-top site

Visible Multifilter Rotating Shadowband Radiometer (vis-MFRSR) data were collected at Storm Peak Laboratory (SPL), a mountain-top facility in northwest Colorado, from 1999 to 2011 and in 2013. From 2011 to 2014, in situ measurements of aerosol light scattering were also obtained. Using these data sets together, the seasonal impact of dust and biomass burning is considered for the western USA. Anal

No particle mass enhancement from induced atmospheric ageing at a rural site in northern Europe

A large portion of atmospheric aerosol particles consists of secondary material produced by oxidation reactions. The relative importance of secondary organic aerosol (SOA) can increase with improved emission regulations. A relatively simple way to study potential particle formation in the atmosphere is by using oxidation flow reactors (OFRs) which simulate atmospheric ageing. Here we report on the

Sequence and context dependence of EF-hand loop dynamics. An 15N relaxation study of a calcium-binding site mutant of calbindin D(9k)

The influence of amino acid sequence and structural context on the backbone dynamics of EF-hand calcium-binding loops was investigated using 15N spin relaxation measurements on the calcium-free state of the calbindin D(9k) mutant (A14D+A15Δ+P20Δ+N21G+P43M), in which the N-terminal pseudo- EF-hand loop, characteristic of S100 proteins, was engineered so as to conform with the C-terminal consensus E

Southern travelling habits with special reference to tumour site in Swedish melanoma patients

Southern travelling habits were recorded for 127 melanoma patients from southern parts of Sweden (the 56th latitude), 55 thyroid cancer patients, 100 non-Hodgkin's patients and 794 healthy controls from the same region. Melanoma patients were found to travel significantly more often south of the 45th latitude, as compared with patients with non-Hodgkin's lymphoma or thyroid carcinoma (RR = 2.2 for

From a rural idyll to an industrial site: an analysis of hydraulic fracturing energy sprawl in Central Appalachia

This paper analyzes land-system dynamics changes due to energy infrastructure development and explores the environmental and social ramifications of hydraulic fracturing, through a case study in Central Appalachia. Grounded in photographic data, satellite images, and ethnographic material, this study demonstrates landscape and embodied experiences of change over time. Data show major shifts in ter

Lorcaserin bidirectionally regulates dopaminergic function site-dependently and disrupts dopamine brain area correlations in rats

Lorcaserin, which is a selective agonist of serotonin2C receptors (5-HT2CRs), is a new FDA-approved anti-obesity drug that has also shown therapeutic promise in other brain disorders, such as addiction and epilepsy. The modulation of dopaminergic function might be critical in the therapeutic effect of lorcaserin, but its exact effect is unknown. Here, we studied the effect of the peripheral admini