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Phase 1/2a clinical trial of BI-1206, an anti-CD32b (FcγRIIB) antibody, in combination with pembrolizumab in subjects with advanced solid tumors previously treated with anti-PD-1/PD-L1.

2593Background: PD-1 blockade has demonstrated positive anti-tumor activity across multiple tumor types. While the anti-tumoral response can be substantial and even curative, response rates remain low in many cancer types. Long-lasting responses are only observed in a minority of patients, and additional immunotherapeutic alternatives remain limited for patients who fail to respond or initially re

Recurrent risk of hospitalization among older persons with problematic alcohol use: A multiple failure-time analysis with a discontinuous risk model

Background and AimsOlder persons with problematic alcohol use vary in psychosocial functioning, age of onset for problem drinking and use of other drugs. The study measured the differential risks of all-cause, alcohol, polydrug and psychiatric-related repeated hospitalizations among older persons with problematic alcohol use.DesignA linked register-based cohort study with discontinuous multiple-fa

Investigating Buyer Preferences in Climate Finance Under Article 6.2 of the Paris Agreement

This thesis investigates buyer preferences in the procurement of Internationally Transferred Mitigation Outcomes (ITMOs) under Article 6.2 of the Paris Agreement, which facilitates international cooperation through carbon markets. As ITMO markets are still in the early stages of development, uncertainties regarding regulatory frameworks, environmental integrity, and procurement strategies have eme

Biological Activities of Natural and Semi-Synthetic Pseudo-Guaianolides: Inhibition of Transcription Factors

Popular Abstract in English The sesquiterpene lactones is an important group of natural products, and they are present in many medicinal plants. Their most important biological activities are anti-inflammatory and anti-cancer activity, although for many decades their potential use as drugs was dismissed. The main reason for this was their alkylating capacity, reacting with thiol functions in proteDamsin (1) is a natural sesquiterpene lactone (SL) isolated from Ambrosia arborescens Mill., a plant used in the Andes as antiinflammatory medicine. This natural product is an inhibitor of NF- κB, a protein complex that controls the transcription of many genes in mammalian cells, and has a potential for standing model for the development of new anti-cancer lead structures. In order to improve the

Development of the gastrointestinal tract in young mammals : Effects of enteral provocation with protease or phytohaemagglutinin in neonatal rats

Råttan är en däggdjursart med en kort dräktighetstiden och föds därför mycket omogen. Den är vid födelsen naken, blind och döv och är helt beroende av sin moder för många funktioner, såsom näringstillförsel, termoreglering, urinering och tarmtömning. Under diperioden är råttans mag-tarmsystem och matsmältning helt anpassad till modersmjölkdieten. Bland annat är tarmens barriärfunktion omogen, vilk

EUPRERA Annual Congress 2025

Read more and register About the Euprera Annual Congress The European Public Relations Education and Research Association (EUPRERA) is an autonomous organisation with over 550 members across 50 countries, with a vision of advancing academic research and knowledge in public relations and strategic communication. To achieve this vision, EUPRERA organises a highly regarded Annual Congress in collabor

https://www.isk.lu.se/euprera2025 - 2026-05-07

Who was Kilian Stobaeus?

He was a physician, a scientist and a university vice chancellor. Kilian Stobaeus was the man whose donations formed the foundation for several University departments and museums, and the collection grew intensively over the next century. The Stobaeus Project aims to shed light on his life and achievements. Kilian Stobaeus was born on 6 February, 1690 in Vinslöv in southern Sweden to a well-educat

https://www.historiskamuseet.lu.se/stobaeus-project/who-was-kilian-stobaeus - 2026-05-07

The Impact of the Founding Team’s Human Capital on Token Sale Success: An analysis of European ICOs between 2016-2021

The emergence of blockchain technology enables entrepreneurs to raise capital in an innovative way, by addressing a crowd of online investors without the need for an intermediary. This phenomenon is known as token sales, and it may have the potential to revolutionize entrepreneurial finance. However, information asymmetry is particularly severe in this context, and the need for entrepreneurs to se

Environmental Justice in Mexico: A Narrative Analysis of López Obrador's political agenda, action and rhetoric

On July 2018, for the first time in modern Mexican history, a leftist candidate won the presidential elections in Mexico. With large promises on the eradication of corruption and ending social injustice, Andrés Manuel López Obrador and his party secured both the presidency and both chambers of the Mexican Congress. This paper inquires into to what extent a president belonging to the political left