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In this thesis we present friction studies on InAs nanowires pushed laterally across surfaces by an AFM tip. The contact length in the direction of movement is of the order of a few tens of nanometers, and is thus comparable to that found in existing point-contact studies, but perpendicular to the motion the wire can be several microns in length. We are therefore able to investigate friction in th
Introduction and aims. Mental disorders among perpetrators of violent and sexual crimes differ from those in the general population in prevalence, course, and patterns of comorbidity. The Göteborg Forensic Neuropsychiatry Projects was initiated to map neuropsychiatric vulnerability factors (disorders, deficits, symptoms, and neurobiological aberrations) among violent offenders and analyze the find
Popular Abstract in Swedish Blodcirkulationen fungerar i kroppen som ett transport system för proteiner, syre och andra metaboliter. Blodet har den svåra uppgiften att vara flytande och samtidigt kunna koagulera på ställen där kärlet går sönder. Störning i denna balans leder till sjukdomar som hjärtinfarkt och blodpropp eller motsatsen svåra blödningar. Det protein som jag har studerat ingår vid The subject of this thesis is the activated protein C (APC)-mediated inactivation of factor Va. The activated form of factor V (FVa) is a procoagulant cofactor for Factor Xa (FXa) in the conversion of prothrombin to thrombin. The procoagulant function of FVa is down regulated by APC through proteolytic cleavage at three sites, Arg306, Arg506 and Arg679. The cleavage at Arg506 is kinetically favore
Popular Abstract in Swedish I denna avhandling presenteras fyra nya metoder för att automatiskt mäta hjärtats förmåga att pumpa ut blod i kroppen, mäta storleken på en hjärtinfarkt samt mäta hur stor del av hjärtmuskeln som riskerade att dö vid hjärtinfarkten. Dessa nya metoder kan användas för att minska skillnader mellan mätningar gjorda av olika läkare, på olika sjukhus och i olika forskargrupp
Popular Abstract in Swedish Denna avhandling har den tillämpade psykiatrin som sitt forskningsfält och fokuserar på de problem som har samband med vård och behandling av vuxna patienter med autismspektrumstörning. Avhandlingens syfte är att medverka till att personal inom vuxenpsykiatrin får ökade kunskaper om de svårigheter med kontakt, kommunikation och tänkande som hänger samman med en autismdThe research field of the thesis is clinical adult psychiatry and it focuses on the treatment of patients with autism spectrum disorders. Before the publication of DSM-IV (Diagnostic and Statistical Manual of Mental Disorders) in 1994 intellectually high-functioning patients with autism have not been included in diagnostic manuals and received appropriate treatment in adult psychiatry. In recent y
Popular Abstract in Swedish Insulinberoende diabetes mellitus (IDDM = Typ 1 diabetes), och kronisk sköldkörtelinflammation - autoimmun thyreoidit (AIT) anses idag vara orsakade av att de hormonproducerande cellerna angrips av kroppens eget immunsystem (sk. autoimmunitet). När sjukdomen ger sig till känna kliniskt finnes antikroppar (sk. autoantikroppar) riktade mot cellkomponenter i det hormonprodThe two most common autoimmune endocrine diseases in children are autoimmune thyroiditis (AIT) and Type 1 (insulin-dependent) diabetes mellitus (IDDM). Autoantibodies (ab) can be found several years before clinical diagnosis in both diseases. The aims of this study were to investigate the prevalence of thyroid ab in children with IDDM and in children with allergic diseases; to study islet ab and t
AimTo identify the factors responsible for the low health-related quality of life associated with foot ulcers and the relative importance of these factors. MethodsA total of 1232 patients with a new foot ulcer, who presented at one of the 14 centres in 10 European countries participating in the Eurodiale study, were included in this cross-sectional study. Patient and ulcer characteristics were obt
The environment in which biology exists has dramatically changed during the last decades. Life was formed during billions of years, exposed to, and shaped by the original physical forces such as gravitation, cosmic irradiation and the terrestrial magnetism. The existing organisms are created to function in harmony with these forces. However, in the late 19th century mankind introduced the use of e
BACKGROUND: There is limited evidence of the effects of local anesthesia (LA) on outcomes of non-surgical periodontal treatment (NSPT), in particular among the Chinese. This retrospective cohort study aimed to evaluate the effects of LA on short-term treatment outcomes of NSPT and to determine under what circumstances LA should be prescribed to improve these outcomes. METHODS: Data from periodonta
The presence of organ-specific autoantibodies including islet cell surface, cytoplasmic and cytotoxic as well as thyroid-gastric antibodies were determined in healthy, non-diabetic, first-degree relatives to 30 insulin-dependent diabetic (IDDM) children. Thirty healthy families without family-history of diabetes mellitus served as controls. The prevalence of organ-specific autoantibodies among the
Purpose: To present a single-centre experience with endovascular treatment of patients with severe symptoms secondary to acute pulmonary embolism (PE). Material and methods: Twenty-five patients were treated due to contraindications or deficient effects of systemic throbolytic therapy. The patients were treated with a combination of fragmentation and aspiration, only aspiration, only fragmentation
The present thesis investigates gender assignment in Jamtlandic from a sociolinguistic and historical/comparative perspective. Jamtlandic is a language variety spoken in northwestern Sweden in the province of Jämtland. It maintains a three-gender system, in contrast to Standard Swedish, which has a two-gender system. Study 1 of the thesis looks at Jamtlandic gender assignment from a sociolinguisti
BACKGROUND/AIMS: Metabolically healthy obesity (MHO) remains controversial, since the underlying mechanisms behind this phenotype remain unclear. We aimed to investigate the characteristics of MHO, as well as prospective risks.METHOD: A cross-sectional analysis was carried out in a subsample of 3812 obese subjects selected from the Malmo diet cancer study (n=28,403). Subjects with MHO (n=1182) wer
Jupiter Trojans are a resonant asteroidal population characterised by photometric colours that are compatible with trans-Neptunian objects, high inclinations, and an asymmetric distribution of the number of asteroids between the two swarms. Different models have been proposed to explain the high inclination of the Trojans and to interpret their relation with the Trans-Neptunian objects, but none o
Background: Subjective well-being refers to the extent to which a person believes or feels that her life is going well. It is considered as one of the best available proxies for a broader, more canonical form of well-being. For over 30 years, one important distinction in the conceptualization of subjective well-being is the contrast between more affective evaluations of biological emotional reacti
BACKGROUND: Triticum aestivum (wheat) is one of the world's oldest crops and has been used for >8000 years as a food crop in North Africa, West Asia and Europe. Today, wheat is one of the most important sources of grain for humans, and is cultivated on greater areas of land than any other crop. As the human population increases and soil salinity becomes more prevalent, there is increased pressure
Introduction: The diagnosis of progressive supranuclear palsy (PSP) is often challenging since PSP may clinically resemble other neurodegenerative disorders. Recently, the tau PET tracer [18F]RO948, a potential new biomarker for PSP, was developed. The aim of this study was to determine the ability of three different biomarkers, including [18F]RO948 PET, to distinguish PSP patients from healthy co
Objective Most reports on the declining incidence of myocardial infarction (MI) during the COVID-19 have either been anecdotal, survey results or geographically limited to areas with lockdowns. We examined the incidence of MI during the COVID-19 pandemic in Sweden, which has remained an open society with a different public health approach fighting COVID-19. Methods We assessed the incidence rate (
BACKGROUND: Patients with advanced gastrointestinal stromal tumours (GISTs) resistant to the tyrosine kinase inhibitors imatinib and sunitinib may be treated with regorafenib, which resulted in a median progression-free survival (PFS) of 4.8 months in the GRID trial. Also, pazopanib, another tyrosine kinase inhibitor, has been studied in a randomized, placebo-controlled trial (PAZOGIST) in the thi
