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Introduction: Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths worldwide. Cyclooxygenase-2 (COX-2), which plays a key role in the biosynthesis of prostaglandin E2 (PGE2), is often up-regulated in CRC and in other types of cancer. PGE2 induces angiogenesis and tumor cell survival, proliferation and migration. The tumor suppressor 15-hydroxyprostaglandin dehydrogenase (1

Background: To target specific neuronal populations by gene transfer is challenging. A complicating fact is that populations of neurons may have opposing roles despite being found adjacent to each other. One example is the medium spiny neurons of the striatum. These cells have different projection patterns, a trait used in this study to specifically target one population. New Method: Here we prese

OBJECTIVE The authors aimed to develop the first clinical grading scale for patients with surgically treated spontaneous supratentorial intracerebral hemorrhage (ICH). METHODS A nationwide multicenter study including 401 ICH patients surgically treated by craniotomy and evacuation of a spontaneous supratentorial ICH was conducted between January 1, 2011, and December 31, 2015. All neurosurgical ce

Background and aims: The ReFLeCT study demonstrated that switching to insulin degludec from other basal insulins was associated with reductions in glycated hemoglobin and hypoglycemic events in type 1 (T1D) and type 2 diabetes (T2D), and reductions in insulin doses in T1D. The aim of the present analysis was to assess the short- and long-term cost-effectiveness of switching to insulin degludec in

Aim A key component of library management is meeting the needs of our users. This requires continuous analysis of user experience followed by library development. The aim of this study was to better understand the use and effect of general user surveys (GUS) and other methods of gathering user input for quality assessment and improvement of library activities. Methods Data collection was done via

Purpose: Although tumor infiltrating lymphocytes (TIL) assessment has been acknowledged to have both prognostic and predictive importance in triple negative breast cancer (TNBC), it is subject to inter and intra-observer variability that has prevented widespread adoption. Here we constructed a machine-learning based breast cancer TIL scoring approach and validated its prognostic potential in multi

How do regions change their development path? We contribute to the growing literature on agency in regional development by combining it with a focus on the institutions that shape, support and constrain change agency in pursuit of different types of development paths. We answer the call for micro-level perspectives on regional economic change, using an in-depth and comparative case study approach.

Groundwater is a crucial source of water supply in drought conditions, and an auxiliary water source in wet seasons. Due to its increasing importance in view of climate change, predicting groundwater level (GWL) needs to be improved to enhance management. We used adaptive neuro-fuzzy inference systems (ANFIS) to predict the GWL of the Urmia aquifer in northwestern Iran under various input scenario

Objectives: MRI-only radiotherapy (RT) provides a workflow to decrease the geometric uncertainty introduced by the image registration process between MRI and CT data and to streamline the RT planning. Despite the recent availability of validated synthetic CT (sCT) methods for the head region, there are no clinical implementations reported for brain tumors. Based on a preceding validation study of

INTRODUCTION: 'The diabetic hand' has traditionally referred to hand complications due to diabetes mellitus (DM), including trigger finger (TF) and Dupuytren's disease (DD). Recent publications have also proposed DM as a risk factor for carpal tunnel syndrome (CTS), ulnar nerve entrapment (UNE), and possibly osteoarthritis (OA) of the first carpometacarpal (CMC-1) joint. This study aimed to explor

Background. Pervasive refusal syndrome (PRS) is a severe child psychiatric syndrome not yet included in the international classification and mostly affecting girls aged 7-15 years. Hospital admission and severe loss of function extend for many months and years but most recover. Autism has been suggested as a predisposing factor but largely lacks support for typical cases of PRS. Treatment is not e

Mesenchymal stromal cells (MSCs) were identified more than 50 years ago, and research advances have promoted the translation of pre-clinical studies into clinical settings in several diseases. However, we are only starting to uncover the local factors that regulate cell phenotype, cell function, and cell viability across tissues following administration in different diseases. Advances in pre-clini

Vertical ground heat exchangers (GHEs) used with ground source heat pump systems have been constructed in a variety of configurations including single U-tubes, double U-tubes, quadruple U-tubes, and coaxial-type. Selections of vertical GHE other than single U-tubes are often motivated by a desire to decrease the borehole thermal resistance and therefore reduce the required amount of drilling and/o

Objective: The aim of this study was to assess the performance of kynurenine/tryptophan ratio for tuberculosis (TB) case-finding among antiretroviral therapy (ART)-naive people with HIV (PWH), and to investigate other factors associated with kynurenine/tryptophan ratio in this population. Design: A nested case-control study based on a cohort of 812 ambulatory PWH in the Oromia region, Ethiopia. Me

This study focuses on the severity gradation of non-collision events. Earlier theoretical work has suggested that a proper severity measure for an event should reflect the risk of personal injury, which is often split into two components, including the risk of a collision and the potential consequences had the collision taken place. While a great number of severity measures have been suggested, mo

Lund University Centre for Sustainability Studies 2/3 3/3 Klimatförändring som vetenskap och politik, 7,5 högskolepoäng MESS51 LITERATURE LIST 2021-05-20 1/3 Dnr STYR 2021/1324 Science and Politics of Climate Change, 7,5 credits MESS51 litteraturlista fastställd av LUCSUS styrelse den 20 maj 2021. 1. Bathiany, S., Scheffer, M., Van Nes, E., Williamson, M., & Lenton, T. (2018). Abrupt Climate Chang

https://www.lumes.lu.se/sites/lumes.lu.se/files/2021-05/MESS51%20Climate%20Change%20May%202021.docx - 2026-05-16

Sida 1 av 19 Diarienummer STYR 2024/695 STYR 2024/2395 STYR 2025/622 Gäller från och med 2025-09-01 Musikhögskolan arbets- och delegationsordning 1 Inledning Arbets- och delegationsordningen för Musikhögskolan i Malmö (Musikhögskolan) är fastställd av Musikhögskolans institutionsstyrelse 2025-03-26. Detta dokument kompletterar och specificerar de beslutsbefogenheter som har vidaredelegerats till i

https://www.mhm.lu.se/internt/sites/mhm.lu.se.internt/files/2025-08/Rev_Musikho%CC%88gskolan%20ADO_beslut_INS250326_giltig-250901_korr-dnr_250516.pdf - 2026-05-16

Välkomna till CASE-dagen 2026 Mitt hem är min borg 16 APRIL 2026 CASE: Centre for Ageing & Supportive Environments STEVEN SCHMIDT, KOORDINATOR FÖR CASE, DOCENT Fyra fakulteter samarbetar 2007-2017: ”Centre of Excellence” med integrerad forskarskola finansierad av Forte* Från januari 2018: ett förnyat, nätverksorienterat centrum Samarbete mellan medicinska, tekniska (LTH), samhällsvetenskapliga och

https://www.case.lu.se/sites/case.lu.se/files/2026-04/Urval%20presentationer%20CASE-dagen%202026.pdf - 2026-05-16

Utbildningsplan Kandidatprogram i personal- och arbetslivsfrågor Faculty of Fine and Performing Arts Master of Fine Arts programme, 120 credits KAFKO, Konstnärligt masterprogram i fri konst, 120 högskolepoäng Second-cycle degree programme requiring previous university study / Program med akademiska förkunskapskrav och med slutlig examen på avancerad nivå Details of approval The syllabus was approv

https://www.khm.lu.se/en/sites/khm.lu.se.en/files/2021-12/Utbildningsplan%20master_final_20200401_eng%20_uppdaterad%2020211210.pdf - 2026-05-16

Faculty of Fine and Performing Arts Master of Fine Arts programme, 120 credits KAFKO, Konstnärligt masterprogram i fri konst, 120 högskolepoäng Second-cycle degree programme requiring previous university study / Program med akademiska förkunskapskrav och med slutlig examen på avancerad nivå Details of approval The syllabus was approved by the Board of the Faculty of Fine and Performing Arts on 14

https://www.khm.lu.se/en/sites/khm.lu.se.en/files/2024-10/KAFKO__Master_of_Fine_Arts.pdf - 2026-05-16