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Objectives. Patients diagnosed with RA have an increased risk of some cancers. However, limited data are available on the important issue of prognosis of RA patients with cancer. Methods. RA patients were identified from the Swedish Hospital Discharge Register by linkage to the Cancer Registry. Follow-up of patients was started from the date of diagnosis of cancer through year 2006. Hazard ratios

The aim of this thesis was to characterize a personal denuder/filter sampler for isocyanate aerosol and to study the emission of airborne particles from the interaction between studded tires and pavements. Both types of aerosols are highly relevant for health studies in public and occupational environments. The adverse health effects of airborne isocyanate exposure are well known in the occupatio

Objective. To psychometrically evaluate the Swedish translations of the short forms of the Pelvic Floor Impact Questionnaire (PFIQ-7), Pelvic Floor Distress Inventory (PFDI-20) and Pelvic organ prolapse/Urinary incontinence Sexual questionnaire (PISQ-12). Design and setting. University hospital. Sample. Forty-four patients awaiting prolapse surgery. Methods. The dual panel translation method follo

OBJECTIVE: To explore the characteristics and outcome of patients after stroke admitted to early supported discharge (ESD) services, and to investigate changes over time. STUDY POPULATIONS: Patients admitted between June 1997 and September 1998 and participating in a follow-up study (n = 87) and all patients admitted in 2005-06 (n = 226). Background populations: All stroke cases in Malmö alive 3 m

Windstorms have caused severe damage on several occasions in Sweden during the last century. A general concern about future projections of climate extremes has raised questions on the variations and impacts of windstorms. The main objective with this work was to reach a deeper understanding of the variability and possible trends in ­windstorms, and related storm impacts in forests. This was achiev

Popular Abstract in Swedish Bildning, bearbetning och upplagring av cathepsin G, proteinas 3 och azurocidin - närbesläktade bakteriedödande proteiner i vita blodkroppar Människans kropp utsätts dagligen för fientliga attacker av olika sorters mikroorganismer, tillhörande bakterie-, virus- eller svampsläktet. Så länge vi är friska och vårt immunförsvar fungerar, kan vi som tur är framgångsrikt föThe neutrophil granulocyte contains a number of multifunctional proteins stored in different subsets of granules. The azurophil granules, synthesized early during differentiation, harbour leukocyte elastase, cathepsin G, proteinase 3, and azurocidin; the members of the serprocidin family. In order to study the biosynthesis, processing, and intracellular sorting of the proteins, human cDNA encoding

Popular Abstract in Swedish Transplantation av dopaminceller från mänskliga foster kan förbättra funktionen hos patienter med Parkinsons sjukdom (Lindvall 1997, Björklund 2000a). Man har kunnat visa att transplantaten har återställt dopaminproduktionen i striatum till normala nivåer i flera fall, och till 70-80% av normalt i majoriteten av de patienter som transplanterats i Lund. Transplantaten haTransplantation of embryonic human neural tissue can restore function in patients with Parkinson’s disease, but there is a severe shortage of donor tissue which limits the applicability of the technique. Embryonic neural tissue from other species, xenogeneic tissue, would provide a readily accessible donor tissue with the potential to help patients if the immunological reactions in the host could

NMR (nuclear magnetic resonance) spektroskopi, är en omfattande teknik som har många applikationer inom kemin. Det kan användas inom organisk kemi som stöd och underlag till strukturbestämning av molekyler, men framför allt finns det många tillämpningar inom biokemi och molekylärbiologi där tekniken utnyttjas; NMR är mycket användbart för att studera biomolekylers strukturer och biologiska processThis study aims to present a protocol for pH determination in biomolecular NMR samples by evaluating the pH dependence of chemical shifts in the most commonly reported buffer molecules in the BioMagResBank (BMRB). Whilst there exists multiple methods and protocols for intrinsic NMR pH determination and various molecules have been proposed as pH indicators, there is no method to determine the actua

Ensuring close control of critical quality attributes (CQAs), such as post-translational modifications (PTMs), in therapeutic monoclonal antibodies (mAbs) is essential for maintaining function and batch homogeneity in large-scale production. Common PTMs include deamidation, fragmentation, oxidation, charge variants, and glycosylations. This study aimed to evaluate CQA variations and correlate the

The aim of our study was to examine how the staff at community residences handles the residents’ right and ability to make choices and decisions regarding their health, in relation to their disability. We investigated this through semi-structured interviews. Our population consisted of 7 staff members from 4 different community residences, in 3 municipalities in Skåne, Sweden. We constructed an in

This paper analyzes if there exist a statistical relationship between liquidity on stock, listed at NASDAQ OMX Nordic Stockholm, and financial stress. Liquidity is approximated by volume turnover, and financial stress is represented by SIXVX implied volatility index. To find out if stock liquidity responds differently to financial stress, depending on capitalization value, the stocks were divided

Populärvetenskaplig sammanfattning: En mycket reaktiv spårgas i Amazonas. Växter släpper ut flyktiga organiska ämnen, som är mycket viktiga eftersom de släpps ut i stora mängder och påverkar tillverkningen av aerosoler, förändrar luftkvaliteten och fungerar som kommunikation mellan växter och herbivorer. Det här arbetet presenterar uppmätningar av sesquiterpener, vilka är flyktiga organiska partikSesquiterpenes are highly reactive terpenoids produced by vegetation and may serve many important biological functions such as acting as antioxidants and as semiochemicals (chemicals acting as messengers within or between species). Once emitted to the atmosphere, by reacting with oxidants like ozone and contributing to secondary organic aerosol formation, the emission of sesquiterpenes from vegeta

En ofta använd behandlingsmetod mot cancer är strålbehandling. Inför en sådan behandling undersöks patienten ofta med en typ av röntgenundersökning som kallas datortomografi (eng. computed tomomgraphy, CT). Röntgenbilderna visar hur mycket av strålningen som absorberas av kroppen, vilket innebär att man tydligt ser skillnad mellan ben, som absorberar mer av strålningen än vävnad och luft, som strå"Introduction; The aim of this study was to examine the possibilities for MRI-based radiotherapy treatment planning. The work included evaluation of geometric image distortions in MR-images, investigations of how segmentation of bone could be performed from images acquired with the ultra short time of echo (UTE) pulse sequence and assessment of dosimetric differences between treatment plannin

Background: Surgery for spontaneous primary intracerebral hemorrhage (ICH) remains controversial. Previous surgical trials have primarily focused on short-term mortality while studies on long-term functional outcome are rare. We therefore conducted this retrospective study of long-term outcome on all ICH patients who underwent craniotomy at a single neurosurgical center during a 10-year period. Me

Familial risks for histopathology-specific cancers have not been determined. We used the nationwide Swedish Family-Cancer Database on 10.2 million individuals and 1 million tumors to calculate standardized incidence ratios (SIRs) for familial cancers of specific histology and morphology among 0- to 66-year-old offspring. We used histology codes for both offspring and parents, but because of the li

OBJECTIVES: To compare and examine whether, when and how patients with lung cancer in three countries, with different survival rates, talk about cigarette smoking and its relationship with help-seeking. DESIGN: A qualitative cross-country comparison with analysis of narrative interviews. SETTING: Participants in Sweden, Denmark and England were interviewed during 2015-2016. Interviews, using a nar

BACKGROUND: The available literature does not present a "gold standard" for post-operative pain treatment after total hip arthroplasty (THA). The aim of this prospective observational study was to explore and document post-operative pain treatment, including outcomes, in a large cohort of patients undergoing THA at five different Danish hospitals.METHODS: This prospective, multicentre, observation

We present new in-situ measurements of particle rotations and energy dissipation during compression of 3D packings of stiff, frictional particles. Two confined, uniaxial compression tests with different degrees of lateral confinement are discussed. X-ray computed tomography and 3D X-ray diffraction were combined to provide inter-particle forces, slip and roll distances, twist angles, and energy di

Hemorrhagic cystitis (HC) is a debilitating complication following allogenic hematopoietic cell transplantation (HCT). HLA disparity and T-cell depletion have been implicated as risk factors for HC. However, reports on the incidence and risk factors for HC in ex vivo T-cell depleted haploidentical HCT (haploHCT) in children are lacking. We studied 96 haploHCT procedures performed in 83 children be

Exacerbation frequency is central in treatment strategies for chronic obstructive pulmonary disease. However, whether chronic obstructive pulmonary disease patients from the general population with frequent exacerbations continue to have frequent exacerbations over an extended period of time is currently unknown. In this study, we aimed to investigate the stability of the frequent exacerbator in a