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AbstractBackground and purpose: The need for knee replacement revision arises from a combination of patient, prosthesis and surgeon factors. Registry data can help study these relationships. Pooling data from multiple registries may increase both reliability and generalizability. The study aim was to gain a multi-national overview of knee replacement revision, to inform best-practice and improve o
GTP-cyclohydrolase deficiency in dopa-responsive dystonia (DRD) patients impairs the biosynthesis of dopamine, but also of serotonin. The high prevalence of non-motor symptoms suggests involvement of the serotonergic pathway. Our study aimed to investigate the serotonergic system in vivo in the brain of`DRD patients and correlate this to (non-)motor symptoms. Dynamic [11C]DASB PET scans, a marker
Twenty-three lines from a mutagenized Bangladeshi BARI Gom-25 wheat population that included previously identified salt-tolerant lines, and the BARI Gom-25 control variety, were cultivated in a drip-irrigated salinity test field at Salt Farm Texel, Netherlands, to assess their performance during salt stress in European climatic conditions. Lines were tested at irrigation salinity levels of 1, 4, 8
CONTEXT: Minipuberty, a period of a transient activation of the hypothalamic-pituitary-gonadal (HPG) axis in both sexes, enables evaluation of gonadal function in infants suspected of hypogonadism. However, female minipuberty remains poorly elucidated. OBJECTIVE: We aimed to establish continuous reference ranges for the most commonly used reproductive hormones and to evaluate the dynamics of the H
BACKGROUND: Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) has improved the survival in selected colorectal cancer patients with peritoneal metastases. In these patients, the risk of a low anastomosis is sometimes diminished through the creation of a colostomy. Currently, the morbidity and mortality associated with the reversal of the colostomy in this population
Background: Clubfeet are typically shorter than normal feet. This study aimed first to describe the development of foot length in a consecutive series of children with congenital clubfoot and second to relate foot length to development of relapse and motion quality. Methods: Foot length was measured every 6 months in 72 consecutive children with congenital clubfoot (29 bilateral) aged from 2 to 7
The ACMG/AMP guidelines include five categories of which variants of uncertain significance (VUSs) have received increasing attention. Recently, Fowler and Rehm claimed that all or most VUSs could be reclassified as pathogenic or benign within few years. To test this claim, we collected validated benign, pathogenic, VUS and conflicting variants from ClinVar and LOVD and investigated differences at
Introduction: Elevated pulmonary vascular resistance (PVR) is observed in both physiological and pathological states. Pulmonary hypertension (PH) is a condition associated with significant morbidity and mortality in neonates and children and curative pharmacotherapy is lacking in most cases. In utero, a high PVR allows for blood to bypass the lungs through the open ductus arteriosus (DA). Vascular
The placement of gambling problems within the Hierarchical Taxonomy of Psychopathology (HiTOP) framework, which organizes psychopathology alongside broad overarching symptom spectra, is unclear. With the objective to identify associations between gambling problems and the internalizing, externalizing, and thought disorder spectra of the HiTOP, we distributed an online survey to a sample of 1005 Sw
This study examined whether Growth Differentiation Factor-15 (GDF-15) and echocardiographic measures of systolic left ventricular function improve intermediate- and long-term mortality risk prediction beyond the guideline-endorsed GRACE 2.0 score after Acute Coronary Syndrome (ACS). 751 ACS patients were included. GDF-15, left ventricular ejection fraction (LVEF), and global longitudinal strain (G
Background: Five risk factors account for approximately 50% of the global burden of cardiovascular disease. How the presence or absence of classic risk factors affects lifetime estimates of cardiovascular disease and death from any cause remains unclear. Methods: We harmonized individual-level data from 2,078,948 participants across 133 cohorts, 39 countries, and 6 continents. Lifetime risk of car
Background: Dementia is a growing public health concern, and although diet is a modifiable potential risk factor, the role of free sugar intake remains unclear. Excess sugar has been linked to metabolic and cardiovascular dysfunction, both associated with cognitive decline, but evidence regarding specific sugar sources is limited. Objectives: This study aimed to investigate the associations betwee
Blood biomarkers have the potential to revolutionize Alzheimer's disease diagnosis, offering advantages over CSF and PET due to their accessibility, scalability and cost-effectiveness. This study evaluated the effectiveness of individual plasma biomarkers, such as phosphorylated Tau (pTau) 217, as well as biomarker combinations, with a focus on the pTau 217/β-Amyloid (Aβ) 1–42 ratio to predict amy
The NEO model, developed by Lindström (2019) for paperboard, is a non-linear material model that utilizes empirically based constitutive relations with switches to mimic elastic-plastic responses. Due to the explicit definition of the constitutive relations, the NEO model does not require a constitutive equilibrium loop. This, in addition to modeling flexibility from the switches, poses the NEO mo
The construction industry has always been changing and adapting to new innovations, values, requirements, and goals from the outside world. These days are no different. The climate change is still mostly relevant and everything we could do to mitigate this should be applied in the construction sector. It is nowadays a known fact that buildings represent a significant portion of the carbon dioxide
The Capability to Age in Place: Access to Life from the Home to the Community Despite Vulnerability Chair: Steven Schmidt, Sweden Session Type: Symposia One pillar of UN Sustainable Development Goal 11 (2016) is to make cities inclusive, and in light of population ageing, many Western countries are implementing policies to promote ageing in place. With age being the main predictor of functional de
Lund University Centre for Sustainability Studies 2/3 3/3 Klimatförändring som vetenskap och politik, 7,5 högskolepoäng MESS51 LITERATURE LIST 2021-05-20 1/3 Dnr STYR 2021/1324 Science and Politics of Climate Change, 7,5 credits MESS51 litteraturlista fastställd av LUCSUS styrelse den 20 maj 2021. 1. Bathiany, S., Scheffer, M., Van Nes, E., Williamson, M., & Lenton, T. (2018). Abrupt Climate Chang
https://www.lumes.lu.se/sites/lumes.lu.se/files/2021-05/MESS51%20Climate%20Change%20May%202021.docx - 2026-05-18
Bol. Soc. Mat. Mexicana (3) Vol. 19, 2013 TWO APPLICATIONS OF PERMUTATION TESTS IN BIOSTASTICS LUIS LEÓN-NOVELO, KAISA M. KEMPPAINEN, ALEXANDRIA ARDISONNE, AUSTIN DAVIS-RICHARDSON, JENNIE FAGEN, KELSEY GANO, ERIC W. TRIPLETT, AND TEDDY STUDY GROUP ABSTRACT. We show two examples of how we answer biological questions by converting them into statistical hypothesis testing problems. We consider gene a
Årshögtid LUNDS UNIVERSITET | 31 JANUARI 2020 4 ÅRSHÖGTID Produktion och layout: Akademiintendenturen vid Lunds universitet Foto: Omslag och sidan 2: Kennet Ruona. Sidan 7: Gunnar Menander Sidan 8: Kristian Pohl/Regeringskansliet och Johan Persson Sidan 9: Maria Strömvik, Jenny Loftrup och Erika Fransson Sidan 10: My Rask och Julia Wikström Upplaga: 400 ex. ISBN 978-91-7895-324-0 (tryck) ISBN 978-
https://www.lu.se/sites/www.lu.se/files/skrift_arshogtid_2020-webb.pdf - 2026-05-18
