Search results

Purpose: Objective diagnosis of symptomatic urinary tract infections in patients prone to asymptomatic bacteriuria is compromised by local host responses that are already present and the positive urine culture. We investigated interleukin-6 as a biomarker for nonfebrile urinary tract infection severity and diagnostic thresholds for interleukin-6 and 8, and neutrophils to differentiate between asym

In a previous pharmacokinetic/pharmacodynamic study in nonbleeding hemophilia patients, variability in laboratory response to recombinant factor VIIa (rFVIIa) 90 μg/kg was noted, and the patients were described as delayed or rapid laboratory responders based on time to clot formation. The current study determined whether in-vitro experiments could reproduce previous in-vivo findings; whether the d

AIMS: Adult mammalian cardiomyocytes are traditionally viewed as being permanently withdrawn from the cell cycle. While some groups have reported none, others have reported extensive mitosis in adult myocardium under steady state conditions. Recently, a highly specific assay of (14)C dating in humans has suggested a continuous generation of cardiomyocytes in the adult, albeit at a very low rate. M

An appreciable percentage of patients with serum anti-glomerular basement membrane (anti-GBM) antibodies also have antineutrophil cytoplasmic antibodies (ANCA), against either myeloperoxidase (MPO-ANCA), or proteinase 3 (PR3-ANCA). In sera without ANCA, the anti-GBM antibodies have been shown to react mainly with the noncollagenous domain (NC1) of Type IV collagen, and especially with its alpha 3

Choline acetyltransferase (ChAT) is the key-enzyme for acetylcholine (ACh) synthesis and constitutes a reliable marker for the integrity of cholinergic neurons. Cortical ChAT activity is decreased in the brain of patients suffering from Alzheimer's and Parkinson's diseases. The standard method used to measure the activity of ChAT enzyme relies on a very sensitive radiometric assay but can only be

Objective: To examine the intertester reliability of the three activities of the Cumulated Ambulation Score (CAS) and the total CAS, and to define limits for the smallest change in basic mobility that indicates a real change in patients with hip fracture.Design: An intertester reliability study.Setting: An acute 20-bed orthopaedic hip fracture unit.Subjects: Fifty consecutive patients with a media

AIMS: In western countries out-of-hospital ischaemic heart disease (IHD) deaths account for approximately 50-70% of all IHD deaths. The objective was to examine the trends in out-of-hospital IHD deaths in the Region of Skåne in southern Sweden, in different sex- and age-groups. METHODS: All 14,347 persons (range 24-110 years) in Skåne who died out-of-hospital between 1992 and 2003 from IHD (I410-

BACKGROUND: Analysis of high-frequency QRS amplitudes (HF-QRS) may provide an additional diagnostic tool in patients with heart disease, but the basic properties of these waveforms have not been sufficiently investigated. This study describes the spatial, individual, and temporal variation at rest of HF-QRS recorded with the 12 standard electrocardiographic leads in patients with ischemic heart di

This paper reviews current issues regarding short-term (i.e. for surgery and invasive procedures) and long-term (i.e. regular infusions to prevent bleeding on a permanent or temporary basis) prophylaxis treatment using replacement concentrates for patients with von Willebrand disease (VWD) who do not respond satisfactorily to desmopressin. The standard treatment of these patients is with factor co

We have studied the state of Cyt b559 and the Mn cluster by EPR and optical spectroscopy in the different S-states between pH 4.0-10.0. In these experiments, the pH was changed after the OEC turnover to the appropriate S-state (at pH 6.0) by 0-3 saturating flashes. Furthermore, the state of Cyt b559 after a subsequent flash given after the pH modification was also investigated. The results show th

The stabilization characteristics and local extinction structures of partially premixed methane/air flames were studied using simultaneous OH-PLIF/PIV techniques, and large eddy simulations employing a two-scalar flamelet model. Partial premixing was made in a mixing chamber comprised of two concentric tubes, where the degree of partial premixing of fuel and air was controlled by varying the mixin

Fuel cells are electrochemical devices that convert chemical energy into electricity. Solid oxide fuel cells (SOFCs) are a particularly interesting type because they can reform hydrocarbon fuels directly within the cell, which are possible thanks to their high operating temperature. The purpose of this study is to develop an anode-supported SOFC theoretical model, to enhance the understanding of t

In this article, various ways of understanding names and their significance for identity is discussed. A comparison between announcements in the births columns in two Swedish daily papers from 1965 and 1995 reveals that it is much more common to announce the child’s name today. This can be interpreted in relation to the conception of the vulnerability of the new-born baby, documented in the Folkli

Acute thromboembolic occlusion in the superior mesenteric artery (SMA) is a condition with high mortality and morbidity. Multi-detector computerised tomography with intravenous contrast enhancement (MDCTiv) may improve diagnostic accuracy and survival. Patients with acute SMA occlusion were identified between 2004 and 2008 at Malmö University Hospital, Sweden. Medical records were analysed. Each M

To understand the function of a biological membrane like that of chloroplast thylakoids, it is important to understand the arrangement of its different protein and lipid components. Preparations that have proven to be particularly suited for such studies are those consisting of membrane vesicles that are turned inside-out. Inside-out vesicles from the thylakoid membrane were first obtained from sp

Accessibility in public outdoor environments is an important issue for persons with reduced functional capacity, for example older persons, and is also crucial for older pedestrians’ safety. The aim of the paper is to evaluate the importance and satisfaction of accessibility issues in public outdoor environments the year around as perceived by older persons (65 years old and above). Within two bef

The propagation channel determines the fundamental basis of wireless communications, as well as the actual performance of practical systems. Therefore, having good channel models is a prerequisite for developing the next generation wireless systems. This thesis first investigates one of the main channel model building blocks, namely clusters. To understand the concept of clusters and channel chara

In order to study protein function and activity structural data is required. Since experimental structures are available for just a small fraction of all known protein sequences, computational methods such as protein modelling can provide useful information. Over the last few decades we have predicted, with homology modelling methods, the structures for numerous proteins. In this study we assess t