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Detection and identification of anomalies in wireless mesh networks using Principal Component Analysis (PCA)

Anomaly detection is becoming a powerful and necessary component as wireless networks gain popularity. In this paper, we evaluate the efficacy of PCA based anomaly detection for wireless mesh networks (WMN). PCA based method [1] was originally developed for wired networks. Our experiments show that it is possible to detect different types of anomalies, such as Denial-of-service (DoS) attack, port

Population biology and conservation of beetles and pseudoscorpions associated with hollow oaks

Popular Abstract in Swedish Eftersom gamla träd har blivit mycket ovanligare de senaste 200 åren, både i skogslandskapet och på ängs- och hagmarker, har djur som lever i gamla träd blivit mycket sällsyntare och många arter är utrotningshotade. I gamla ekar bildas ofta mulm i stammarnas håligheter. Mulmen består av murket trämjöl och i den lever en rik och specialiserad fauna som framför allt utgörMany species associated with old trees are threatened, as this habitat has decreased severely in Europe during the last 200 years. In old oaks, hollows with wood mould often form in the trunks and these harbour a specialized fauna mainly consisting of beetles, flies and pseudoscorpions. This thesis contains the first quantitative examination of the habitat requirements and population ecology of sp

Investigating genetic factors behind the decline of a threatened plant species – Tephroseris integrifolia (Asteraceae)

Landscape change in Europe has caused the decline of many grassland species. Tephroseris integrifolia (Asteraceae) is one species which has declined rapidly in Sweden since the 19th century. A census of extant populations from 1980 to 2009 revealed a dramatic decrease in population sizes during the early 1990s, despite far-reaching conservation measures. Knowledge of causes of species decline is n

Microcalorimetric methods for direct measurement of solubility and solvent activity

New calorimetric methods for direct measurement of solubility and solvent activity are presented. The classical role of calorimetry for measurements of enthalpic parameters is abandoned and the technique is instead used for assessing thermodynamic quantities related to the chemical potential of a substance in a solution. Isothermal calorimetry is here employed as a general analytical method where

Insights into weak affinity antibody-antigen interactionsStudies using affinity chromatography and optical biosensor

Popular Abstract in Swedish I cellen styrs allt av biomolekylernas förmåga till igenkänning och växelverkan med varandra. Molekylernas speciella egenskaper bygger upp kroppens alla komplicerade funktioner, till exempel immunförsvar, celldelning och muskelarbete. Interaktionerna mellan biomolekylerna kan vara av olika karaktär; de beskrivs som starka eller svaga (affinitet), långsamma eller snabba Molecular recognition and interaction is fundamental for the function of biological systems. The properties of the interacting biomolecules dictate the type of forces involved and the strength and dynamics of the interaction. Many interactions are very strong whereas others exhibit weak affinity. Typically, weak interactions work in concert to trigger a biological response. The advantage with thi

Discordant Neural Xenografting: Analysis and Modulation of Immune Responses

Popular Abstract in Swedish Transplantation av dopaminceller från mänskliga foster kan förbättra funktionen hos patienter med Parkinsons sjukdom (Lindvall 1997, Björklund 2000a). Man har kunnat visa att transplantaten har återställt dopaminproduktionen i striatum till normala nivåer i flera fall, och till 70-80% av normalt i majoriteten av de patienter som transplanterats i Lund. Transplantaten haTransplantation of embryonic human neural tissue can restore function in patients with Parkinson’s disease, but there is a severe shortage of donor tissue which limits the applicability of the technique. Embryonic neural tissue from other species, xenogeneic tissue, would provide a readily accessible donor tissue with the potential to help patients if the immunological reactions in the host could

A single nucleotide polymorphism in the NCF1 gene leading to reduced oxidative burst is associated with systemic lupus erythematosus

Objectives: Ncf1 polymorphisms leading to low production of reactive oxygen species (ROS) are strongly associated with autoimmune diseases in animal models. The human NCF1 gene is very complex with both functional and non-functional gene copies and genotyping requires assays specific for functional NCF1 genes. We aimed at investigating association and function of the missense single nucleotide pol

Circulating Midregional Proadrenomedullin and Risk of Incident Abdominal Aortic Aneurysm : A Prospective Longitudinal Cohort Study

Prospective clinical plasma biomarker studies in abdominal aortic aneurysm (AAA) pathogenesis have been hampered by the need for very large cohorts and long follow-up time. The main aim of the present study was to evaluate the association of adrenomedullin, a cardiovascular (CV) stress marker, and incident AAA risk. Prospective longitudinal cohort of middle-aged individuals from the CV cohort of t

Autoimmune type 1 diabetes : Resolved and unresolved issues

Based on the presence of autoantibodies and a strong HLA linkage, type 1 diabetes is now classified as a chronic autoimmune disease. Many issues, however, remain unresolved. Although autoantibodies to GAD65, IA-2, and insulin are clearly markers for this disease, it is not known whether they contribute to pathogenesis or are simply the response to an existing underlying destructive process. Based

Temporal pattern of host responses against intrastriatal grafts of syngeneic, allogeneic or xenogeneic embryonic neuronal tissue in rats

The host response to immunologically incompatible intrastriatal neural grafts was studied using immunohistochemical techniques. Dissociated ventral mesencephalic tissue from embryonic donors of either syngeneic, allogeneic or xenogeneic (mouse) origin was stereotaxically implanted into adult rats. The brains were analysed 4 days, 2 weeks or 6 weeks after grafting with antibodies against the follow

Lobectomy for non-small cell lung carcinoma : a nationwide study of short- and long-term survival

Introduction: Lobectomy is the standard curative treatment for non-small cell carcinoma (NSCLC) of the lung. Most studies on lobectomy have focused on short-term outcome and 30-day mortality. The aim of this study was to determine both short-term and long-term surgical outcome in all patients who underwent lobectomy for NSCLC in Iceland over a 24-year period. Material and methods: The study involv

The human B1 bradykinin receptor exhibits high ligand-independent, constitutive activity : Roles of residues in the fourth intracellular and third transmembrane domains

The B1 bradykinin (BK) receptor (B1R) is a seven-transmembrane domain, G protein-coupled receptor that is induced by injury and important in inflammation and nociception. Here, we show that the human B1R exhibits a high level of ligand-independent, constitutive activity. Constitutive activity was identified by the increase in basal cellular phosphoinositide hydrolysis as a function of the density

Analysis of C3 gene variants in patients with idiopathic recurrent spontaneous pregnancy loss

Miscarriage is the most common complication of pregnancy. Approximately 1% of couples trying to conceive will experience recurrent miscarriages, defined as three or more consecutive pregnancy losses and many of these cases remain idiopathic. Complement is implicated both in the physiology and pathology of pregnancy. Therefore, we hypothesized that alterations in the C3 gene could potentially predi

Pyritization history in the late Cambrian Alum Shale, Scania, Sweden: Evidence for ongoing diagenetic processes

Detailed diagenetic studies of the late Cambrian Alum Shale in southern Sweden were undertaken across an interval that includes the peak Steptoean Positive Carbon Isotope Excursion (SPICE) event to evaluate the pyrite mineralization history in the formation. Samples were collected from the Andrarum-3 core (Scania, Sweden); here the Alum was deposited in the distal, siliciclastic mudstone-rich end

The Malmo polymorphism of coagulation factor IX, an immunologic polymorphism due to dimorphism of residue 148 that is in linkage disequilibrium with two other F.IX polymorphisms

A mouse monoclonal antibody (MAB 9,9) to coagulation factor IX (F.IX) detects a polymorphism in the plasma of normal people. Its epitope has been narrowed down to <6 amino acids in the activation peptide of the X-linked F.IX protein. The activation peptide contains a dimorphism - Thr:Ala - at position 148 of the protein. Using synthetic oligonucleotides, we have demonstrated that (1) the F.IX whic

Genetic variation of the Toll-like receptors in a Swedish allergic rhinitis case population

Background: Variation in the 10 toll-like receptor (TLR) genes has been significantly associated with allergic rhinitis (AR) in several candidate gene studies and three large genome-wide association studies. These have all investigated common variants, but no investigations for rare variants (MAF≤1%) have been made in AR. The present study aims to describe the genetic variation of the promoter and

Evaluation of the trust in physician scale (TIPS) of primary health care patients in north-east Poland : A preliminary study

Background. Trust is a complex concept, difficult to study, but very important in a patient-family physician relationship. One of the measures used to assess interpersonal trust is a scale developed by Anderson & Dedrick entitled the Trust in Physician Scale (TI PS). Objectives. The aim of the study was to assess the TI PS properties in relation to the age, gender, and health status of primary

Effects of CH4 Content on NO Formation in One-Dimensional Adiabatic Flames Investigated by Saturated Laser-Induced Fluorescence and CHEMKIN Modeling

Experiments applying saturated laser-induced fluorescence (LSF) technology were performed focusing on the influence of equivalence ratio, syngas mixture contents, on NO formation in H2/CO/CH4/CO2/N2/O2 premixed flat flames supplied by a heat flux burner. Experimental data were extracted to validate calculation by CHEMKIN software. Both experiments and CHEMKIN calculation draw one conclusion that N

Effect on mother and child of eculizumab given before caesarean section in a patient with severe antiphospholipid syndrome

Rationale: Antiphospholipid syndrome (APS) in pregnancy may trigger the life-threatening catastrophic antiphospholipid syndrome (CAPS). Complement activation is implicated in the pathogenesis, and inhibition of complement factor C5 is suggested as an additional treatment option. Patient concerns, diagnosis and interventions: We present a pregnant patient treated with the C5-inhibitor eculizumab du