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Cyanogenic Potential of Roasted Cassava (Manihot esculenta Crantz) roots Rale from Inhambane Province, Mozambique

Roasted cassava roots flour is part of a common meal in Africa, it is known as rale in Mozambique. Fifty six samples of rale were collected from homes and markets in Inhambane Province, Mozambique, for cyanogenic potential (CNp) analyses. The names of cassava varieties used for preparing the rale samples could be determined in the home-collected samples, three varieties were recorded. Xinhembwe va

Optimised machine learning for time-to-event prediction in healthcare applied to timing of gastrostomy in ALS : a multi-centre, retrospective model development and validation study

Background: Amyotrophic lateral sclerosis (ALS) is invariably fatal but there are large variations in the rate of progression. The lack of predictability can make it difficult to plan clinical interventions. This includes the requirement for gastrostomy where early or late placement can adversely impact quality of life and survival. Methods: We designed a model to predict the timing of gastrostomy

Spatially different annual cycles but similar haemosporidian infections in distant populations of collared sand martins

BackgroundPopulations of long-distance migratory birds experience different environments and are consequently exposed to different parasites throughout their annual cycles. Though, specific whereabouts and accompanied host-parasite interactions remain unknown for most migratory passerines. Collared sand martins (Riparia riparia) breeding in the western Palaearctic spend the nonbreeding period in A

Role of GDF-15, YKL-40 and MMP 9 in patients with end-stage kidney disease : focus on sex-specific associations with vascular outcomes and all-cause mortality

Background: Sex differences are underappreciated in the current understanding of cardiovascular disease (CVD) in association with chronic kidney disease (CKD). A hallmark of CKD is vascular aging that is characterised, amongst others, by; systemic inflammation, microbiota disbalance, oxidative stress, and vascular calcification—features linked to atherosclerosis/arteriosclerosis development. Thus,

Personal comorbidities and their subsequent risks for liver, gallbladder and bile duct cancers

Many environmental risk factors for hepatobiliary cancers are known but whether they are associated with specific cancer types is unclear. We present here a novel approach of assessing standardized incidence ratios (SIRs) of previously diagnosed comorbidities for hepatocellular carcinoma (HCC), gallbladder cancer (GBC), cholangiocarcinoma (CCA) and ampullary cancer. The 13 comorbidities included a

Nanowire-Based Visible Light Emitters, Present Status and Outlook

So far, the semiconductor nanowire research area has mainly delivered results on growth procedures and related material properties. As the development lately has been successful in producing novel nanowire-based structures for optical or electronic applications, the time is ripe to review the device work that has been done and in some cases has produced devices ready for the market. In this chapte

Participation in cardiovascular screening consultations, the who, when and why - A cohort study on patients with rheumatoid arthritis

Background: In accordance with the EULAR recommendations, the Danish Hospital for Rheumatic Diseases have systematically invited patients with rheumatoid arthritis (RA) to cardiovascular (CV) risk assessment since 2011. Patients with high risk are invited to a follow-up screening after one year. To optimize the screening and tailor it to individual needs, information about who accepts vs. declines

Beta-lactam antibiotic concentrations in critically ill patients with standard and adjusted dosages: A prospective observational study

IntroductionAntibiotic concentration target attainment is known to be poor in critically ill patients. Dose adjustment is recommended in patients with altered clearance, obesity and those with bacterial species with intermediate susceptibility. The aim of this study was to investigate the variation of antibiotic concentration in critically ill patients with standard or adjusted dosing regimens.Met

An inter-comparison of inverse models for estimating European CH4 emissions

Atmospheric inversions are widely used to evaluate and improve inventories of methane (CH4) emissions across scales from global to local, combining observations with atmospheric transport models. This study uses the dense network of in situ stations of the Integrated Carbon Observation System (ICOS) to explore how well in situ data can constrain European CH4 emissions. Following the concept of int

Pesticide exposure among organic and conventional smallholder farmers in Costa Rica and Uganda : biomarker evidence on exposure determinants

BACKGROUND: Pesticides play a crucial role in pest control; however, exposure remains high, particularly among smallholder farmers in low-income and middle-income countries (LMICs) with little access to pesticide safety training. This study aimed to provide comparative biomarker-based evidence from Latin America and Africa and identify actionable determinants of exposure to inform context-specific

Microstructure imaging in patients undergoing evaluation for epilepsy surgery or low-grade glioma : Clinical utility of a novel diffusion MRI method

OBJECTIVE: To investigate a recently developed MRI technique for mapping the Mean Diffusivity of Tissue (MDT), which improves diffusion MRI imaging of the cerebral cortex by reducing partial volume effects from cerebrospinal fluid (CSF). As cortical lesions are common in patients with focal epilepsy, we explored the clinical value of MDT imaging in patients with drug resistant epilepsy and low-gra

Advances in the monitoring and forecasting of urban extreme meteorological events : a bibliometric review

Urban meteorology, the study of atmospheric phenomena in urban areas, is vital for understanding the dynamic interactions between rapid urbanization and environmental changes. Over the past two decades (2004–2024), urban heat islands (UHIs), extreme rainfall, pollution, and temperature anomalies have intensified, adversely affecting human health, infrastructure, and ecosystems worldwide. The prese

Hydrophobic interaction chromatography of fibroblast proteoglycans

We have investigated the hydrophobic properties of human skin fibroblast proteoglycans and related material by affinity chromatography on Octyl-Sepharose CL-4B in 4 M guanidinium hydrochloride (GdnHCl). Proteoglycans and related material could be separated into non-, medium and highly hydrophobic forms by elution with gradients of Triton X-100 in 4 M Gdn HCl. The non-hydrophobic material included

Treatment of packaging board whitewater in anaerobic/aerobic biokidney

Whitewater from production of packaging board was treated in a combined anaerobic/aerobic biokidney, both in laboratory scale and pilot plant experiments. Both the laboratory experiments and the pilot plant trial demonstrate that a combined anaerobic/aerobic process is suitable for treating whitewater from a packaging mill. It is also possible to operate the process at the prevailing whitewater te

Risk stratification score screening for infective endocarditis in patients with Gram-positive bacteraemia

Background: A feared cause of bacteraemia with Gram-positives is infective endocarditis. Risk stratification scores can aid clinicians in determining the risk of endocarditis. Six proposed scores for the use in bacteraemia; Staphylococcus aureus (PREDICT, VIRSTA, POSITIVE), non-β-haemolytic streptococci (HANDOC) and Enterococcus faecalis (NOVA, DENOVA) were validated for predictive ability and the

Innovation with and without patents

A long-standing discussion is to what extent patents can be used to monitor trends in innovation activity. This study quantifies the amount and quality of information about actual innovation contained in the patent system, based on 4,460 Swedish innovations (1970-2015) that have been matched to international patents. The results show that most innovations were not patented and that among those tha

Self-reported limitations in physical function are common 6 months after out-of-hospital cardiac arrest.

BackgroundOut-of-hospital cardiac arrest (OHCA) survivors generally report good health-related quality of life, but physical aspects of health seem more affected than other domains. Limitations in physical function after surviving OHCA have received little attention.AimsTo describe physical function 6 months after OHCA and compare it with a group of ST elevation myocardial infarction (STEMI) contr

High versus low-added sugar consumption for the primary prevention of cardiovascular disease

Background: High intake of added sugar have been suggested to impact the risk for cardiovascular disease (CVD). Knowledge on the subject can contribute to preventing CVD. Objectives: To assess the effects of a high versus low-added sugar consumption for primary prevention of CVD in the general population. Search methods: We searched Cochrane Central Register of Controlled Trials (CENTRAL) in the C