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Recent animal studies have shown that D-glucose is a potential biodegradable MRI contrast agent for imaging glucose uptake in tumors. Here, we show the first translation of that use of D-glucose to human studies. Chemical exchange saturation transfer (CEST) MRI at a single frequency offset optimized for detection of hydroxyl protons in D-glucose (glucoCEST) was used to image dynamic signal changes

The term Anthropocene denotes a new geological epoch characterized by the unprecedented impact of human activities on the Earth’s ecosystems. While the natural sciences have advanced their understanding of the drivers and processes of global change considerably over the last two decades, the social sciences lag behind in addressing the fundamental challenge of governance and politics in the Anthro

Lattice Boltzmann method (LBM) is alternative computational method to the traditional computational fluid dynamic (CFD) methods. LBM has the ability to with straightforward computational procedure to handle the detail activity at microscale well for simulation of different transport processes. In this study the focus is on the effects of electrochemical reactions and transport processes in an anod

CONTEXT: Once islet autoantibody-positive individuals are identified, predicting which individuals are at highest risk for type 1 diabetes (T1D) is important. A metabolic risk score derived from 2-hour oral glucose tolerance test (OGTT) data, the Diabetes Prevention Trial-Type 1 risk score (DPTRS), can accurately predict T1D. However, 2-hour OGTTs are time-consuming and costly. OBJECTIVE: We aimed

Reliable safe water supply is a pillar of society and a key to public health. The Nordic countries have an abundance of clean fresh water as a source for drinking water supplies. They have followed developments in safeguarding water, both the recommendations of the World Health Organization framework for safe drinking water and European legislation. Worldwide, including the Nordic countries, small

Background: More women in reproductive ages are entering occupations where exposure to whole body vibrations (WBV) is common (e.g. in transportation and construction). Previous studies based on self-assessed exposure suggest increased risks of adverse birth outcomes, but it is unclear at what exposure levels and if the current exposure guidelines are appropriate during pregnancy. Objectives: To in

Structural monitoring (e.g. structural measurement and damage detection) and inspections have been widely applied as part of structural maintenance. However, the potential of using the obtained information is not yet fully exploited to update the structural reliability and support the maintenance and operation strategy. This paper describes the foundations, limitations, and characteristics of meas

Purpose: Onyx® embolization causes severe artifacts on subsequent CT-examinations, thereby seriously limiting the diagnostic quality. The purpose of this work was to compare the diagnostic quality of the tailored metal artifact reducing algorithms iMAR to standard reconstructions of CTA in patients treated with Onyx® embolization. Method: Twelve consecutive patients examined with Dual Energy CTA a

Purpose: Neurofilament light (NfL) is a biomarker reflecting neurodegeneration and acute neuronal injury, and an increase is found following hypoxic brain damage. We assessed the ability of plasma NfL to predict outcome in comatose patients after out-of-hospital cardiac arrest (OHCA). We also compared plasma NfL concentrations between patients treated with two different targets of arterial carbon

In this study, global wave climates for present and future climates are simulated by the WAM model, based on wind climate data from the JMA/MRI-AGCM3.2 climate change projection. This study is based on two 6-hourly wind data sets, covering two periods of 1979-2003 (present climate) and 2075-2099 (future climate). These wind data are used to run the WAM model for generating output of wave character

Background: Women who deliver pre-term have been reported to have increased future risks of cardiometabolic disorders. However, their long-term risks of ischemic heart disease (IHD) and whether such risks are due to shared familial factors are unclear. A better understanding of these risks may help improve long-term clinical follow-up and interventions to prevent IHD in women. Objectives: The purp

OBJECTIVE: The authors examined the association between alcohol use disorder (AUD) and risk of suicide, before and after accounting for psychiatric comorbidity, and assessed the extent to which the observed association is due to a potentially causal mechanism or genetic and familial environmental confounding factors that increase risk for both. METHODS: Longitudinal population-wide Swedish medical

In this volume, the authors reflect on the question “what is socialism” as it pertains to today’s economy. There is particular emphasis on democratic socialism models as a potential alternative to classic authoritarian socialism. A number of topical questions are addressed such as: What is democratic socialism and is it feasible, or even viable? What can be learnt from existing democratic socialis

Serum amyloid A (SAA) is a well-described acute phase protein induced during the acute phase response (APR) to infection. Four isoform specific genes are found in most mammals. Depending on species, SAA3 and SAA4 are ge0nerally preferentially expressed extrahepatically whereas SAA1 and SAA2 are hepatic isoforms dominating the SAA serum pool. Little is known about how specific infections affect the

Disease recurrence in surgically treated lung adenocarcinoma (AC) remains high. New approaches for risk stratification beyond tumor stage are needed. Gene expression-based AC subtypes such as the Cancer Genome Atlas Network (TCGA) terminal-respiratory unit (TRU), proximal-inflammatory (PI) and proximal-proliferative (PP) subtypes have been associated with prognosis, but show methodological limitat

The Emergency Management sector in Denmark consists of 24 Municipal Fire and Rescue Services (MFRSs) responsible for providing a justifiable response to prevent, limit, and redress personal injury and damage to property and the environment arising from accidents and disasters. This research investigates how the MFRSs throughout Denmark define and direct the prevention and response parameters of qu

Strengthening of masonry walls is a means to improve the energy performance of modern external masonry walls without further increasing their total thickness. The present paper evaluates the feasibility - here refer-ring to ease-of-application and structural performance - of several techniques aimed at strengthening mason-ry walls subjected to eccentric axial loading. Four full scale walls made of

In this study a dynamic model of a solid oxide fuel cell (SOFC) system has been developed. The work has been conducted in a cooperation between the Department of Energy Sciences, Lund University, and Mode Ion AB using the Modelica language and the Dymola modeling and simulation tool. Modelica is an equation based, object oriented modeling language, which promotes flexibility and reuse of code. The