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Var går gränsen för vilka avvikelser från samhällets grundvalar som kan tolereras? När så kallade pietister framträdde i Sverige vid 1700-talets början uppstod en ny problematik kring toleransens gränser i Sveriges historia. Till skillnad från i övriga Europa hade dessförinnan religiösa avvikare inte funnits i någon större omfattning. Pietisterna uppfattades som ett hot mot den gemensamma religion

The Davies transformation is a method to transform the steering vector of a uniform circular array to another vector with Vandermonde form. However, this transformation can be highly sensitive to perturbations of the underlying ideal array model. In this paper, we describe a method for deriving a more robust transformation using optimisation techniques. The effectiveness of the method is illustrat

While immunomodulatory monoclonal antibodies (mAbs) have therapeutic efficacy against many tumors, few patients are cured. Attempting to improve their therapeutic efficacy we have applied the TC1 mouse lung carcinoma model and injected established subcutaneous tumors intratumorally with 3 weekly doses of various combinations of mAbs. Combinations of mAbs to CTLA4/PD1/CD137 (the 3 mAb combination)

Hydrogen is an element of fundamental importance for energy but hard to quantify in bulk materials. Neutron radiography was used to map . in situ loss of elemental hydrogen from beech tree wood samples during pyrolysis. The samples consisted of three wood cylinders (finished dowel or cut branch) of approximately 1 cm in length. The samples were pyrolyzed under vacuum in a furnace vessel that was p

Objectives: Gram-positive, anaerobic cocci (GPAC) can cause infections in humans. Only a few cases of bacteraemia with GPAC have been reported. We describe the clinical and microbiological characteristics of GPAC bacteraemia. Methods: A retrospective population-based study of GPAC bacteraemia 2012–2016 in southern Sweden was performed. GPAC were identified using matrix-associated laser desorption

CONTEXT: The time-to-glucose-peak following the oral glucose tolerance test (OGTT) is a highly reproducible marker for diabetes risk. In obese youths, we lack evidence for the mechanisms underlying the effects of the TCF7L2 rs7903146 variant on glucose peak. METHODS: We analyzed the metabolic phenotype and the genotype for the TCF7L2 rs7903146 in 630 obese youths with normal (NGT) and impaired (IG

A massive population growth in cities is currently being witnessed in most countries around the world. As urban populations grow, cities eventually expand geographically into what was considered countryside and nowadays distinguishing between what is city and what is countryside is getting increasingly difficult. In many Western countries, it is being observed that areas near cities seem to capita

AIM: The relative roles(s) of impaired insulin secretion vs. insulin resistance in the development of gestational diabetes mellitus depend upon multiple risk factors and diagnostic criteria. Here, we explored their relative contribution to gestational diabetes as defined by the WHO 1999 (GDM1999) and adapted WHO 2013 (GDM2013) criteria, excluding the 1-h glucose value, in a high-risk Indian popula

Objectives: Dysglycemia and glycemic variability are associated with poor outcomes in critically ill patients. Targeted temperature management alters blood glucose homeostasis. We investigated the association between blood glucose concentrations and glycemic variability and the neurologic outcomes of patients randomized to targeted temperature management at 33°C or 36°C after cardiac arrest. Desig

Posttraumatic stress disorder (PTSD) is associated with increased risk for Type 2 diabetes and cardiovascular disease (cardiometabolic disease), warranting research into targeted prevention strategies. In the present case–control study of 160 young (mean age 32.7 years) male military veterans, we aimed to assess whether PTSD status predicted increased markers of cardiometabolic risk in otherwise h

Stars in open clusters are expected to share an identical abundance pattern. Establishing the level of chemical homogeneity in a given open cluster deserves further study as it is the basis of the concept of chemical tagging to unravel the history of theMilkyWay.M67 is particularly interesting given its solar metallicity and age as well as being a dense cluster environment.We conducted a strictly

Connecting the complementary facilities MAX IV & ESS with DESY & European X-FEL creates synergy and a globally unique infrastructure region with fantastic opportunities for innovation and research not least in Life Science. Through Hanseatic League of Science (HALOS) the Life Science research and innovation ecosystems is given a joint platform to take advantage of the facilities and a tool

The objective is to study the effect of high voltage pulses on living cells to find the most effective combination of physical parameters to be used in tumour therapy. Four parameters that affect the cell survival are the pulse shape, electric field strength, pulse length and the number of pulses and their cell killing effect were investigated in this work. High voltage square wave or exponentiall

In an earlier study, infection of human pancreatic islets with epidemic strains of echovirus (E4, E16, E30), with proven but differently ability to induce islet autoimmunity, resulted either in a severe damage (i.e. E16 and E30) or proceeded without visible changes in infected islets (i.e. E4). In this study, the ability of these strains to replicate in beta cells and the consequence of such an in

The design and features of frequency-selective wallpaper created for attachment onto regular walls in order to filter out signals operating at 5 GHz while at the same time allowing the desired radio communication services to propagate through such walls are presented. An analysis of the characteristics of the radio channel evaluated in a typical indoor environment, when considering either regular