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Mandatory vaccination interferes with personal integrity but may be necessary to safeguard public health. However, states must consider all relevant factors in context and ensure such policies do not place disproportionate burdens on those hesitant about vaccination.

Purpose: The purpose of this study is to investigate the effects of film holes’ arrangements and jet Reynolds number on flow structure and heat transfer characteristics of jet impingement conjugated with film cooling in a semicylinder double wall channel. Design/methodology/approach: Numerical simulations are used in this research. Streamlines on different sections, skin-friction lines, velocity,

In this contribution we present some preliminary results on the dynamical evolution of two planet systems around stellar hosts evolving from the main sequence to the white dwarf phase. The aim is to study the instabilities triggered by stellar evolution that may bring planets onto the stellar surface or produce planetary scale collisions (hence debris) that could explain the metallic atmospheric p

Carbohydrate deficient glycoprotein syndromes (CDG) are inherited multisystem disorders characterized by the abnormal glycosylation of a number of serum glycoproteins. CDG-Ia results from deficiency of phosphomannomutase that catalyzes the conversion of mannose-6-phosphate to mannose-1-phosphate in the cytosol. We report a case of CDG-Ia in an 11-month-old girl with developmental delay, failure to

We obtained 10/192 and 3/384 antibody-secreting hybrids after immunization of Balb/c mice with either human growth hormone or affinity-purified rabbit anti-(human growth hormone) respectively. Radiolabelled rabbit anti-(human growth hormone) antibodies, but not human growth hormone, were specifically bound by supernatants from the 13 hybrids. The binding was completely inhibited by human-growth-ho

Meeting stricter legal emission limits and the simultaneous introduction of new synthetic fuels are key challenges for current and future research in the field of engine combustion. A deep knowledge of spray behavior is mandatory to address these problems, as air‐fuel mixture and spray propagation in gasoline direct injection (GDI) are essential processes to achieve a highly efficient and clean co

In an explorative manner, this article uses a data-driven digital history set-up to focus on how the Swedish Riksdag, its political parties and parliament members discussed media issues. By distant reading and topic modeling a dataset of more than 11,000 parliamentary minutes – approximately 400 million characters – the article gives a new perspective of Swedish media history in general and nation

Chromosomal rearrangements (e.g., fusions/fissions) have the potential to drive speciation. However, their accumulation in a population is generally viewed as unlikely, because chromosomal heterozygosity should lead to meiotic problems and aneuploid gametes. Canonical meiosis involves segregation of homologous chromosomes in meiosis I and sister chromatid segregation during meiosis II. In organism

Purpose: Endwall film cooling protects vane endwall by coolant coverage, especially at the leading edge (LE) region and vane-pressure side (PS) junction region. Strong flow impingement and complex vortexaa structures on the vane endwall cause difficulties for coolant flows to cover properly. This work aims at a full-scale arrangement of film cooling holes on the endwall which improves coolant effi

Mitochondrial dysfunction has been implicated in major depressive disorder (MDD). A measure of mitochondrial respiratory chain (RC) enzymatic activity—the Mitochondrial Health Index (MHI)—has previously been found to correlate with stress and emotional states in caregivers. We here report mitochondrial RC activities, mitochondrial DNA copy number (mtDNAcn), and the composite MHI in unmedicated and

NGC 2419 is one of the remotest star clusters in the Milky Way halo and its exact nature is yet unclear. While it has traits reminiscent of a globular cluster, its large radius and suggestions of an abundance spread have fueled the discussion about its origin in an extragalactic environment, possibly the remnant of the accretion of a dwarf galaxy. Here, we present first results from deep intermedi

Infectious diseases often vary seasonally in a predictable manner, and seasonality may be responsible for geographical differences in prevalence. In temperate regions, vector-borne parasites such as malaria are expected to evolve lower virulence and a time-varying strategy to invest more in transmission when vectors are available. A previous model of seasonal variation of avian malaria described a

This chapter describes the musculoskeletal (MSK) context in children and young people as an important contributor to the global non-communicable disease burden. Through selected MSK conditions, we describe the impact on patients, families and communities and highlight the challenges that need to be addressed. We focus on opportunities for better working together and describe exemplar initiatives t

Sustainably produced renewable biomass has the potential to replace fossil-based feedstocks, for generation of biobased fuels and chemicals of industrial interest, in biorefineries. In this context, seaweeds contain a large fraction of carbohydrates that are a promising source for enzymatic and/or microbial biorefinery conversions. The thermoanaerobe Thermoanaerobacterium AK17 is a versatile ferme

We previously showed that SerpinE2 and the serine protease HtrA1 modulate fibro-blast growth factor (FGF) signaling in germ layer specification and head-to-tail development of Xenopus embryos. Here, we present an extracellular proteolytic mechanism involving this serpin-protease system in the developing neural crest (NC). Knockdown of SerpinE2 by injected antisense morpholino oligonucleotides did

Artikeln beskriver hur en grammatikdidaktisk modell utformad för en L1-kontext kan användas för grammatikundervisning såväl som för ett språk- och skrivutvecklande arbete i en L2-kontext. Eftersom klassrummen i Sverige, Danmark och Norge allt mer blir språkligt heterogena behöver lärare kunna erbjuda en språkutvecklande under-visning för elever med skilda språkliga förutsättningar. Den modell som The article shows how a grammar-didactic model designed for an L1 context can be used for grammar learning as well as language and writing development in an L2 con-text. Because classrooms in Sweden, Denmark and Norway are becoming increasingly heterogenous, teachers must be able to develop the language of pupils with differing linguistic predispositions. The model that is being proposed is design