Precise regulation of β-cell function is crucial for maintaining blood glucose homeostasis. Pax6 is an essential regulator of β-cell-specific factors like insulin and Glut2. Studies in the developing eye suggest that Pax6 interacts with Mitf to regulate pigment cell differentiation. Here, we show that Mitf, like Pax6, is expressed in all pancreatic endocrine cells during mouse postnatal developmen

Background We aimed to estimate lifetime cumulative risk of thyroid cancer (CRTC) in first-degree relatives of patients with non-medullary thyroid cancers (NMTC), including papillary (PTC)/follicular/oxyphilic/anaplastic thyroid carcinoma, by histology and age at diagnosis in patients and their relatives. Design A population-based cohort of 63 495 first-degree relatives of 11 206 NMTC patients dia

Abstract The last two decades has seen an avalanche of studies establishing Activated protein C (APC) resistance due to Factor V Leiden mutation as the most prevalent genetic risk factor, yet known, for venous thromboembolism. This has been documented in 20-60% of patients with deep vein thrombosis (DVT). Whether such propensity also exists in arterial circulation is still controversial. The gener

Effective human input devices for computer control are very important to quadriplegics and others with severe disabilities. This paper describes a framework for computer control without need for special PC software or drivers. The framework is based on a tongue control system recently developed at Center for Sensory-Motor Interaction (SMI), Aalborg University. The framework provides emulation of a

With the intention of developing a new data analysis method using virtual experiments we have built a detailed virtual model of the cold triple-axis spectrometer RITA-II at PSI, Switzerland, using the McStas neutron ray-tracing package. The parameters characterising the virtual instrument were carefully tuned against real experiments. In the present paper we show that virtual experiments reproduce

One of the main motivations for the great interest in semiconductor nanowires is the possibility of easily growing advanced heterostructures that might be difficult or even impossible to achieve in thin films. For III-V semiconductor nanowires, axial heterostructures with an interchange of the group III element typically grow straight in only one interface direction. In the case of InAs-GaAs heter

The aims of this work is to better determine the genetic background of gestational diabetes (GDM) and to examine how specific genes affect the development of diabetes post partum. In the DiPiS (Diabetes Prediction in Skåne) study we typed for HLA-DQB1 alleled, the transcription factor 7-like 2(TCF7L2) rs7903146, rs12255372 and rs7901695 SNPs, the 1858 C>T SNP of the protein tyrosine phosphatase n

A combined search for the Standard Model Higgs boson with the ATLAS experiment at the LHC using datasets corresponding to integrated luminosities from 1.04 fb(-1) to 4.9 fb(-1) of pp collisions collected at root s = 7 TeV is presented. The Higgs boson mass ranges 112.9-115.5 GeV, 131-238 GeV and 251-466 GeV are excluded at the 95% confidence level (CL), while the range 124-519 GeV is expected to b

Compared to food patterns, nutrient patterns have been rarely used particularly at international level. We studied, in the context of a multi-center study with heterogeneous data, the methodological challenges regarding pattern analyses.

Agricultural management and vegetation complexity affect arthropod diversity and may alter trophic interactions between predators and their prey. Web-building spiders are abundant generalist predators and important natural enemies of pests. We analyzed how management intensity (tillage, cutting of the vegetation, grazing by cattle, and synthetic and organic inputs) and vegetation complexity (plant

We investigate depletion interactions between inert hard colloids in the presence of ideal polymers, with a focus on the case where the polymer radius of gyration (R-g) is equal to the radius of the colloids (R-c). We first establish structure and fluid-fluid phase equilibria of this model system as accurately as possible. To achieve this, we replace the ideal polymers by "effective spheres'', usi

Photosynthetic organisms need protection against excessive light. By using non-photochemical quenching, where the excess light is converted into heat, the organism can survive at higher light intensities. This process is partly initiated by the formation of zeaxanthin, which is achieved by the de-epoxidation of violaxanthin and antheraxanthin to zeaxanthin. This reaction is catalyzed by violaxanth

Popular Abstract in Swedish Solenergi kommer att vara en av de viktigaste miljövänliga energikällorna i framtiden, vilket innebär ökat antal solpaneler (för el och värme) som integreras i våra hus men också som fristående produktionsanläggningar. När man planerar framtida hus och stadsdelar är det viktigt att skapa de bästa förutsättningarna för solenergi eftersom hus och stadsdelar finns kvar i fEnergy use in buildings accounts for a significant proportion of the total energy use in many countries. While past and current buildings have solely been energy consumers, future buildings will, besides using less energy, also need to produce (part of ) the required energy on site with renewables. Solar energy is generally very suitable for producing this on-site renewable energy. Although solar

ABSTRACT: BACKGROUND: Replacing the energy-intensive evaporation of stillage by anaerobic digestion is one way of decreasing the energy demand of the lignocellulosic biomass to the ethanol process. The biogas can be upgraded and sold as transportation fuel, injected directly into the gas grid or be incinerated on-site for combined heat and power generation. A techno-economic evaluation of the spru

By international standards, children in Sweden experience good health. Sweden has low infant mortality rates, low accident mortality rates, a high number of breastfed children and a high proportion of vaccinated children. However, during the past twenty years the prevalence of overweight children has doubled in Sweden, while that of obese children has increased 4-5 times. Furthermore, there has be

Many buildings, both new and old, suffer from moisture-related problems, with negative consequences on health, costs for rebuilding and lost confidence in the building industry. These problems could have been avoided if moisture issues had been focused on and dealt with throughout the building process. A method for including moisture safety in the building process has therefore been developed. The