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Aims and objectives: The aim of this study was to describe how EL was eased, as narrated by frail older people. Background: Existential loneliness (EL) is an unavoidable part of the human condition. It is a complex phenomenon that has been described as disconnection from life. If EL is acknowledged in the care of older people, the experience of EL can be reduced. Design: In this qualitative study,

This paper introduces a predictive combustion-engine controller for efficient fulfillment of constraints on peak pressure, exhaust temperature and NO emissions. The controller utilizes a in-cylinder pressure sensor, actuation of multiple fuel injections and numerical optimization. A physical model is used to predict pressure changes due to fuel-injection variation. The predicted pressure is used t

Here we show that treatment of the HPV16-positive tonsillar cancer cell line HN26 with DNA alkylating cancer drug melphalan-induced p53 and activated apoptosis. Melphalan reduced the levels of RNA polymerase II and cellular transcription factor Sp1 that were associated with HPV16 DNA. The resulting inhibition of transcription caused a rapid loss of the HPV16 early mRNAs encoding E6 and E7 as a res

Nanowires are presently investigated in the context of various biological and medical applications. In general, these studies are population-based, which results in sub-populations being overlooked. Here, we present a single cell analysis of cell cycle and cell movement parameters of cells seeded on nanowires using digital holographic microscopy for time-lapse imaging. MCF10A normal-like human bre

The aim of this study was to explore parents’ experiences of sleep and rest while admitted to hospital together with their ill child. When a child is hospitalized, it can be a traumatic experience for the entire family. Adaptation to the new situation and new parental responsibilities is necessary. Hospitalized children demand more supervision and care, making sleep disturbance a common challenge

Globally, transport increases its share of emissions and the transport sector desperately needs an efficient climate policy including efficient strategies to reduce unsustainable levels of car use. By providing insights into the profile of passenger mileage by car in relation to levels estimated to be sustainable in 2050, this work gives insight into who will, and who needs to, be affected by poli

Partially premixed combustion (PPC) is a hybrid combustion of Homogeneous Charge Compression Ignition (HCCI) and Diesel Combustion (DC), which has a great potential in reducing the fuel consumption. PPC has a longer premixed time than DC but lesser than HCCI. Therefore it is more stratified than HCCI. This paper first presents results on how the stratification using multiple injections and differe

The effect of combustion on a gliding arc (GA) discharge is investigated using simultaneous measurements of current and voltage waveforms, as well as imaging and spectroscopic analysis of plasma and flame luminescence. Attributed to the existence of flame, the breakdown voltage and current peak are reduced and the bright sparks during breakdown are dampened. The intrinsic reason is largely owing t

Purpose: The purpose of this study is to investigate the effects of human capital and relational trust on business-to-business (B2B) brand equity. Design/methodology/approach: Data collection was conducted among the clients of one of the Big Four auditing firms in Sweden. Structural equation modeling was used to test the hypothesized effects. Findings: The results demonstrate positive effects of h

In the present study, water-oil flow patterns and slug hydrodynamics were experimentally studied in square glass microchannels with various hydraulic diameters (Dh = 600 µm, 400 µm, 200 µm). The aqueous phase is the continuous phase while the organic phase is the dispersed phase. The ranges of flow rates of the continuous phase and the dispersed phase are 0-200 ml/h and 0-12 ml/h, 0-120 ml/h and 0

An in-cycle closed-loop combustion controller is proposed in this paper. The controller uses a pilot-main injection scheme where the cycle-individual properties of the pilot combustion are estimated by in-cylinder pressure measurements, and used to predict their effect on the heat release shape of the main combustion. The prediction is used to obtain the optimal main SOI that gives the Maximum Rea

After Tony Blair resigned as the United Kingdom’s prime minster in June 2007, he was appointed as the official envoy of the Quartet on the Middle East. His appointment was marred with controversy not the least with regard to his suitability for the role and his performance as peace envoy, with many observers questioning his ethical credentials. The EU along with the US, Russia and the UN make up t

Localization microscopy methods like Stochastic Optical Reconstruction Microscopy (STORM) are very well suited for exploring clustering of proteins, as the data inherently provide a list of molecular coordinates. Here we use state-of-art cluster analysis algorithms (DBSCAN) to explore the clustering behaviour of different affinity forms of the integrin LFA-1. It has been suggested that LFA-1 may f

Activation of the contact system generates bradykinin from high-molecular-weight kininogen and has been suggested to participate in the pathophysiology of sepsis. To test this, we prospectively measured bradykinin and high-molecular-weight kininogen levels in a cohort of sepsis patients requiring intensive care. From 29 patients meeting criteria for sepsis or septic shock according to Sepsis-3, bl

Stopovers play a crucial role for the success of migrating animals and are key to optimal migration theory. Variation in refuelling rates, stopover duration and departure decisions among individuals has been related to several external factors. The physiological mechanisms shaping stopover ecology are, however, less well understood. Here, we explore how immune function and blood parasite infection

Background: One goal within positive psychiatry is to support the personal recovery of persons with mental illness and providing opportunities for well-being. Aim: The current article aims to introduce readers to the concept of personal recovery and the potential and importance of recovery-oriented services and measures. Methods: A literature review was conducted to help consider the domains of ‘p

Background/Purpose: The aims of this study were to evaluate bowel and urinary tract function, to identify predictors for dysfunctional outcome and to evaluate health-related quality-of life (QoL) in patients treated for sacrococcygeal teratomas (SCT). Methods: Medical records of patients with SCT born between 1985 and 2015 treated at three Swedish pediatric surgical centers were reviewed. Question

Objectives: Inclusion body myositis is characterized by inflammatory and degenerative changes, but the temporal relation of these events is unknown. Materials and Methods: In nineteen patients with inclusion body myositis, muscle strength was correlated with inflammatory and degenerative findings on magnetic resonance imaging (MRI) and in muscle biopsies in three different muscles (tibialis anteri

Gasoline-fueled Partially Premixed Combustion is an advanced combustion concept approaching high efficiency as well as low emissions. The most challenging task on controlling a gasoline PPC engine is to regulate the maximum pressure rise rate to reduce engine noise and durability problem. A trade-off relationship between pressure rise rate and soot emissions is observed as a function of pilot inje