Phagocytosis of necrotic cells in systemic lupus erythematosus - a possible source of autoantigens?
Abstract Objectives: Serum from patients with systemic lupus erythematosus (SLE) is often characterized by their ability to promote phagocytosis of necrotic cell (NC) by polymorphonuclear leukocytes (PMNs). The aim of this project was to study phagocytosis of NC by PMNs in presence of serum from SLE patients, and associate the ability of phagocytosis with circulating nucleosomes and autoantibodi