Generating new models to study propagation and pathology of alpha-synuclein in Parkinson's disease and multiple system atrophy
Synucleinopthies are neurodegenerative diseases characterised by the formation of α-synuclein-rich intracellular inclusions in neurons and glia. Traditionally, animalmodels and immortalized cell lines have been used to investigate why and how theseinclusions form, and how they impact on cellular function. Recent advances incellular reprogramming and directed differentiation have enabled the genera
