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Neutrophil extracellular traps (NETs)-mediated tissue damage is a hallmark in abdominal sepsis. Under certain conditions, microRNAs (miRs) can regulate protein expression and cellular functions. The aim of this study was to investigate the role of miR-155 in sepsis-induced NET formation, lung inflammation, and tissue damage. Abdominal sepsis was induced in wild-type (WT) C57BL/6 and miR-155 gene-d
Civil servants with close access to monarchs have often been seen as influential advisers. A specific group of civil servants were the Royal Secretaries in Sweden and Spain, and the Secretaries of State in England and France. They all held offices which gave them close and continuous access to their masters.In all the above-mentioned countries these civil servants were recruited from among groups
Peritoneal metastasis is an insidious aspect of colorectal cancer. The aim of the present study was to define mechanisms regulating colon cancer cell adhesion and spread to peritoneal wounds after abdominal surgery. Mice was laparotomized and injected intraperitoneally with CT-26 colon carcinoma cells and metastatic noduli in the peritoneal cavity was quantified after treatment with a CXCR2 antago
The digital games industry is one of the fastest growing branches in the creative sector in Sweden: In the last three years the proportion of employees has increased with about 20 percent. Specific for this branch is that digital games companies compete in a highly globalized and digitalized market dominated by a few large corporations. It creates the backdrop for specific working conditions. PrevThe digital games industry is one of the fastest growing branches in the creative sector in Sweden: In the last three years the proportion of employees has increased with about 20 percent. Specific for this branch is that digital games companies compete in a highly globalized and digitalized market dominated by a few large corporations. It creates the backdrop for specific working conditions. Prev
Background: Knee osteoarthritis (KOA), chronic widespread pain (CWP) and overweight/obesity are public health problems that often coincide, and there is a multifactorial and unclear relationship between them. The study aimed to (1) investigate pain sensitivity, assessed by pressure pain thresholds (PPTs), among women and men with knee pain and (2) associations with, respectively, radiographic KOA
Much contemporary critical infrastructure research has been devoted to studies of the effects of risks stemming from interdependencies between critical infrastructures, here referred to as interdependency-related risks. However, this research has placed limited emphasis on infrastructure actors’ efforts to manage such risks in practice, and it remains unclear to what extent and how critical infras
Falling pitch has long been argued to be a key feature in the distinction of Swedish pitch accents. In this paper, neurophysiological and behavioural evidence substantiating the perceptual importance of HL pitch contours at the word level is discussed. When presentedwith novel words, Swedes, regard-less of dialect,preattentively distinguished meaningfulwords with falling pitch.Falling pitch was al
Bussbranschen kan tillhöra en av de näringar som drabbats hårdast i samband med pandemin (covid-19). Många bussreseföretag är små och medelstora familjeföretag med låga marginaler. Redan vid pandemins början i mars 2020 lyftes en oro för framtiden bland dessa företag. Över ett år senare står stora delar av verksamheterna helt eller delvis stilla på grund av rådande restriktioner och osäkerheten i
In this paper, we consider the flow and heat transfer behaviour of turbulent upward and downward flows of supercritical n-decane, in order to reveal the features of heat transfer deterioration (HTD) that would be expected in relevant active regenerative cooling systems for scramjet engines. Specific focus is placed on key velocity-field features that appear in these flows. Following the validation
In this paper, bistable gates which can be used as building blocks in logic gates are designed using topology optimization. The gate simulation is based on finite strain kinematics and hyperelastic material response. The objective of the optimization is to maximize the stiffness of a gate in the stable configurations while ensuring an adequate energy and distance separations between them and const
Current freight transport is highly dependent on fossil fuels and there is a need for a transition to alternative fuels and technologies. Biogas is a type of biofuel that has the potential to reduce climate emissions from freight transport, while providing additional benefits such as recycling of nutrients and increased energy security. This paper uses theories on the diffusion of green technologi
Brain activation mapping using functional magnetic resonance imaging (fMRI) has been extensively studied in brain gray matter (GM), whereas in large disregarded for probing white matter (WM). This unbalanced treatment has been in part due to controversies in relation to the nature of the blood oxygenation level-dependent (BOLD) contrast in WM and its detectability. However, an accumulating body of
Holocene geomagnetic field models are used to study processes in Earth's core, millennial scale variations in solar activity and to relatively date geological and archaeological archives. Constructing models from magnetic field directions and intensities stored in archaeological artefacts, igneous rocks and sediment records is challenging due to the sparse data distribution and the large chronolog
Changes in the location of γ-tubulin ensure cell survival and preserve genome integrity. We investigated whether the nuclear accumulation of γ-tubulin facilitates the transport of proliferating cell nuclear antigen (PCNA) between the cytosolic and the nuclear compartment in mammalian cells. We found that the γ-tubulin meshwork assists in the recruitment of PCNA to chromatin. Also, decreased levels
