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SPARC: A Potential Prognostic and Therapeutic Target in Pancreatic Cancer.

Pancreatic cancer is a complex and heterogeneous disease that often lacks disease-specific symptoms in early stages. The malignancy is currently the fourth leading cause of cancer-related death in Western countries. In advanced stages, the overall 5-year survival is less than 1% to 2%. Most available treatments lack convincing cost-efficiency determinations and are generally not associated with re

Influence of interface roughness in quantum cascade lasers

We use a numerical model based on non-equilibrium Green's functions to investigate the influence of interface roughness (IFR) scattering in terahertz quantum cascade lasers. We confirm that IFR is an important phenomenon that affects both current and gain. The simulations indicate that IFR causes a leakage current that transfers electrons from the upper to the lower laser state. In certain cases,

Epigenetic adaptation to regular exercise in humans.

Regular exercise has numerous health benefits, for example, it reduces the risk of cardiovascular disease and cancer. It has also been shown that the risk of type 2 diabetes can be halved in high-risk groups through nonpharmacological lifestyle interventions involving exercise and diet. Nevertheless, the number of people living a sedentary life is dramatically increasing worldwide. Researchers hav

Diffraction-limited storage-ring vacuum technology.

Some of the characteristics of recent ultralow-emittance storage-ring designs and possibly future diffraction-limited storage rings are a compact lattice combined with small magnet apertures. Such requirements present a challenge for the design and performance of the vacuum system. The vacuum system should provide the required vacuum pressure for machine operation and be able to handle the heat lo

Carotid artery stenting compared with endarterectomy in patients with symptomatic carotid stenosis (International Carotid Stenting Study): an interim analysis of a randomised controlled trial

Background Stents are an alternative treatment to carotid endarterectomy for symptomatic carotid stenosis, but previous trials have not established equivalent safety and efficacy. We compared the safety of carotid artery stenting with that of carotid endarterectomy. Methods The International Carotid Stenting Study (ICSS) is a multicentre, international, randomised controlled trial with blinded adj

Iron-mediated growth of epitaxial graphene on SiC and diamond

Ordered graphene films have been fabricated on Fe-treated SiC and diamond surfaces using the catalytic conversion of sp(3) to sp(2) carbon. In comparison with the bare SiC(0 0 0 1) surface, the graphitization temperature is reduced from over 1000 degrees C to 600 degrees C and for diamond (111), this new approach enables epitaxial graphene to be grown on this surface for the first time. For both s

The effect of comedication with conventional synthetic disease modifying antirheumatic drugs on TNF inhibitor drug survival in patients with ankylosing spondylitis and undifferentiated spondyloarthritis: results from a nationwide prospective study.

To assess the effect of comedication with conventional synthetic disease modifying antirheumatic drugs (csDMARDs) on retention to tumour necrosis factor inhibitor (TNFi) therapy in patients with ankylosing spondylitis (AS) and undifferentiated spondyloarthritis (uSpA).

Water vapor sorption and diffusivity in bark

Physical properties of importance in drying processes have been compiled for bark, including spruce, pine, and birch in Sweden. Water vapor sorption isotherms were determined for the bark of these trees. At 95% relative humidity and 25 degrees C, outer birch bark reached a moisture ratio (kg water/kg dry mass) of 5%, whereas inner birch bark, spruce bark, and pine bark reached moisture ratios of 2

Mediatization at the Margins : Cosmopolitanism, Network Capital, and Spatial Transformation in Rural Sweden

The significance of mediatization in countryside settings is an under-researched topic in media studies. In this paper, based on qualitative fieldwork carried out in two rural areas in Sweden, we study how mediatization integrates the prospects of cosmopolitan social change. The current phase of the mediatization process, which imposes a more dynamic register of networked communication, nourishes

More than trees! Understanding the agroforestry adoption gap in subsistence agriculture: Insights from narrative walks in Kenya

Agroforestry can contribute to the mitigation of climate change while delivering multiple benefits to sub-Saharan farmers who are exposed to climate variability, land degradation, water scarcity, high disease burden and persistent poverty. But adoption is slow. Based on a critical problem solving approach and grounded theory as a strategy, we study agroforestry and subsistence agriculture as integ

The Rh(100)-(3 × 1)-2O structure.

The O adsorption on Rh(100) has been studied using high resolution core level spectroscopy, low energy electron diffraction and scanning tunnelling microscopy. In addition to the well known (2 × 2), (2 × 2)-pg and c(8 × 2) structures at coverages of 0.25, 0.5 and 1.75 ML respectively, an intermediate (3 × 1) structure with a coverage of 2/3 ML is identified.

Site Preference and Ordering Induced by Au Substitution in the γ-Brass Related Complex Au-Cr-Zn Phases.

The crystal chemistry of the ternary Au-Cr-Zn alloy was studied by means of synthesis, single crystal X-ray diffraction, and electron structure calculations. While the compound CrZn∼17 represents the binary end-point of the homogeneity range, the inclusion of Au proves to be very site specific, and at the limiting composition Au10Cr4Zn89 the structure is completely ordered. The crystallographic si

Earwitnesses: the effect of type of vocal differences on correct identification and confidence accuracy

Individual voice and speech characteristics are important for earwitness identification. A target-absent line-up with six foils was used to analyse the influence of voice and speech features on recognition. To create ecologically valid conditions for voice recognition, the present study used voices in conversation in the target event and for the foils. The participants were particularly successful

The Regime of Excellence and the Erosion of Ethos in Critical Management Studies

The regime of excellence - manifested in journal rankings and research assessments is coming to increasing prominence in the contemporary university. Critical scholars have responded to the encroaching ideology of excellence in various ways: while some seek to defend such measures of academic performance on the grounds that they provide accountability and transparency in place of elitism and privi

Possible Late Pleistocene volcanic activity on Nightingale Island, South Atlantic Ocean, based on geoelectrical resistivity measurements, sediment corings and (14)C dating

Tristan da Cunha is a volcanic island group situated in the central South Atlantic. The oldest of these islands, Nightingale Island, has an age of about 18Ma. In the interior of the island, there are several wetlands situated in topographic depressions. The ages of these basins have been unknown, and their genesis has been debated. Aiming towards the reconstruction of the geomorphological history

Assessing habitat quality of farm-dwelling house sparrows in different agricultural landscapes.

Having historically been abundant throughout Europe, the house sparrow (Passer domesticus) has in recent decades suffered severe population declines in many urban and rural areas. The decline in rural environments is believed to be caused by agricultural intensification, which has resulted in landscape simplification. We used giving-up densities (GUDs) of house sparrows feeding in artificial food

Species Collapse via Hybridization in Darwin's Tree Finches

Species hybridization can lead to fitness costs, species collapse, and novel evolutionary trajectories in changing environments. Hybridization is predicted to be more common when environmental conditions change rapidly. Here, we test patterns of hybridization in three sympatric tree finch species (small tree finch Camarhynchus parvulus, medium tree finch Camarhynchus pauper, and large tree finch:

Urban Peacebuilding in ethno-nationally divided and contested cities: the case of Mostar

This article seeks to outline a conceptual landscape that can assist us to better grasp how urban communities torn and traumatised by violent conflicts remain divided in peace and resistant to liberal peacebuilding efforts. It suggests that peacebuilding needs to be urbanised to better address and mitigate tensions and ethnocratic spatial practices in divided cities. The urban is suggested as a pr