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We here present the first genetic fine mapping of experimental autoimmune neuritis (EAN), the animal model of Guillain-Barre syndrome, in a rat advanced intercross line. We identified and refined a total of five quantitative trait loci on rat chromosomes 4, 10, and 12 (RNO4, RNO10, RNO12), showing linkage to splenic IFN-gamma secretion and disease severity. All quantitative trait loci were shared

Compared to monolingual first language acquisition (L1) and adult second language acquisition (aL2), relatively little research has been done on child second language acquisition (cL2). This is an unsatisfactory situation from both a practical and a theoretical point of view. The present study concerns cL2 acquisition of French and poses the question whether cL2 acquisition bears closer resemblanc

The adsorption of N2O on Ir(110) was investigated with high-resolution resonant photoemission at 135 K. The results obtained show evidence of molecular adsorption of N2O, along with some dissociation. It is found that the nitrogen photoemission spectra measured at the terminal and central nitrogen energy positions of the N2O/Ir(110) system are equivalent to those of N2O in the gas phase. In contra

Silica-filled poly(1-trimethylsilyl-1-propyne) (PTMSP) layers were successfully applied for the first time on top of ultrafiltration support membranes and applied in the pervaporative separation of ethanol/water mixtures. Reduction of the thickness of the separating PTMSP top layer and addition of hydrophobic silica particles resulted in a clear flux increase as compared to dense PTMSP membranes.

This study compared neck range of movement recording using three different methods goniometers (EGM), inclinometers (INC) and a three-dimensional video analysis system (IMG) in simultaneous and synchronized data collection. Twelve females performed neck flexion-extension, lateral flexion, rotation and circumduction. The differences between EGM, INC, and IMG were calculated sample by sample. For fl

A dysregulation in the metabolism of lipids may be an early marker of autoimmunity in Type 1 Diabetes (T1D). It would be of general importance to identify metabolic patterns that would predict the risk for T1D later in life. The aim of this study was to perform a prospective evaluation of glutamine and phospholipids levels in Brazilian first degree relatives (FDR) of patients with T1D in a mean in

TLR agonists are attractive candidate adjuvants for therapeutic cancer vaccines as they can induce a balanced humoral and T cell-mediated immune response. With a dense network of dendritic cells (DCs) and draining lymphatics, the skin provides an ideal portal for vaccine delivery. Beside direct DC activation, TLR agonists may also induce DC activation through triggering the release of inflammatory

Background - In patients with chronic heart failure (CHF), a beta-blocker is generally added to a regimen containing an angiotensin-converting-enzyme ( ACE) inhibitor. It is unknown whether beta-blockade as initial therapy may be as useful. Methods and Results - We randomized 1010 patients with mild to moderate CHF and left ventricular ejection fraction <= 35%, who were not receiving ACE inhibitor

Context and Objective: Intraportal islet transplantation can restore insulin production in type 1 diabetes patients, but its effect is subject to several interfering processes. To assess the influence of beta-cell loss before and during engraftment, we searched for a real-time marker of beta-cell destruction. Previous studies showed that 65-kDa isoform of glutamate decarboxylase (GAD65) is dischar

High-spin states in the odd-odd N=Z nucleus Rb-74(37)37 were studied using the Ca-40(Ca-40,alphanp) reaction. A previously observed odd-spin T=0 band has been extended to I-pi=(31(+)) and an even-spin T=0 band has been observed for the first time to I-pi=(22(+)); both have a pi(g(9/2))circle timesnu(g(9/2)) structure. A strongly coupled low-spin T=0,K=3 band has been interpreted as being based upo

Background: Functional polymorphisms of the solute carrier family 22, member 4 (SLC22A4), runt related transcription factor 1 (RUNX1) and small ubiquitin- like modifier 4 (SUMO4) genes have been shown to be associated with several autoimmune diseases. Objective: To test the possible role of these variants in susceptibility to or severity of systemic lupus erythematosus (SLE), on the basis that com

Emerging lines of evidence indicate that the cutaneous human papillomavirus (HPV) types that belong to the genus Betapapillomavirus (beta HPV) are involved in the development of nonmelanoma skin cancer. Unlike the situation for mucosal HPV types, highly sensitive and reliable methods to identify characterized cutaneous HPV types in a single assay are limited. Here, we describe a novel one-shot met

Popular Abstract in Swedish Ett nytt EU-direktiv om uttjänta fordon har nyligen antagits. Direktivet kräver att från och med 2006 skall 85% av bilens vikt återvinnas och 95% från och med år 2015. Idag återvinns cirka 80%. Bildemonteringsindustrin har valts som studieobjekt i denna avhandling. De höjda återvinningskraven förväntas leda till att bildemonteringsindustrin genomgår omfattande rationaliA new EU directive on used vehicles has recently been introduced. It demands that for every scrapped car, at least 85% by weight must be recycled by the year 2006 and 95% by 2015. The current level is about 80%. The car disassembly industry was chosen as the study object of this thesis. Due to the increased demands on recycling, the disassembly industry may undergo comprehensive rationalizations a

The European Association of Urology non-muscle-invasive bladder cancer (NMIBC) guidelines recommend that all low- and intermediate-risk patients receive a single immediate instillation of chemotherapy after transurethral resection of the bladder (TURB), but its use remains controversial.

Glutamate receptors are well-known actors in the central and peripheral nervous systems, and altered glutamate signaling is implicated in several neurological and psychiatric disorders. It is increasingly recognized that such receptors may also have a role in tumor growth. Here we provide direct evidence of aberrant glutamate signaling in the development of a locally aggressive bone tumor, chondro

The tightly controlled network of cell cycle genes consists of a core of cyclin dependent kinases (CDKs) that are activated by periodically expressed cyclins. The activity of the cyclin-CDK complexes is regulated by cyclin dependent kinase inhibitors (CDKIs) and multiple signal transduction routes that converge on the cell cycle. Neuroblastoma are pediatric tumors that belong to the group of small

In development, epigenetic mechanisms such as DNA methylation have been suggested to provide a cellular memory to maintain multipotency but also stabilize cell fate decisions and direct lineage restriction. In this study, we set out to characterize changes in DNA methylation and gene expression during granulopoiesis using 4 distinct cell populations ranging from the oligopotent common myeloid prog

For the last years, automation is widely used to relieve humans from repetitive tasks, primarily and firstly within manufacturing. However, for products with less ideal (or hard to model) properties, and when forces depends on human interaction, automated testing has not been explored until now. This work presents the analysis of the (human-dependent) motions/forces based on a fully implemented te

The microphase structure of a series of polystyrene-b-polyethylene oxide-b-polystyrene (SEOS) triblock copolymers with different compositions and molecular weights has been studied by solid-state NMR, DSC, wide and small angle X-ray scattering (WAXS and SAXS). WAXS and DSC measurements were used to detect the presence of crystalline domains of polyethylene-oxide (PEO) blocks at room temperature as