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Short-term Revision Risk of Patellofemoral Arthroplasty Is High : An Analysis from Eight Large Arthroplasty Registries

BACKGROUND: Patellofemoral arthroplasty (PFA) is one option for the treatment of isolated patellofemoral osteoarthritis, but there are limited data regarding the procedure and results. Because isolated patellofemoral arthritis is relatively uncommon, available case series generally are small, and even within national registries, sample sizes are limited. Combining data from multiple registries may

Current taxonomy of the lichen family Teloschistaceae from India with descriptions of new species

The present study recorded 36 genera and 115 species of the lichen family Teloschistaceae in India. Three species, i.e. Caloplaca rajasthanica S. Y. Kondr., Upreti et G. P. Sinha, Huriella upretiana S. Y. Kondr., G. K. Mishra, Nayaka et A. Thell, and Squamulea uttarkashiana S. Y. Kondr., Upreti, Nayaka et A. Thell, are described as new species. Seven new combinations, i.e. Fulgogasparrea awasthii

Results of risk-adapted therapy in acute myeloid leukaemia. A long-term population-based follow-up study

In 1997-2003, a protocol for treatment of acute myeloid leukaemia (AML) (except promyelocytic leukaemia) was activated in four Swedish health care regions covering 50% of the national population. Based on cytogenetics and clinical findings, patients aged 18-60 yr were assigned to one of three risk groups. In this report we account for the long-term clinical outcome of enrolled patients. Patients r

European society of clinical microbiology and infectious diseases guidelines for antimicrobial stewardship in emergency departments (endorsed by European association of hospital pharmacists)

Scope: This European Society of Clinical Microbiology and Infectious Diseases guideline provides evidence-based recommendations to support a selection of appropriate antibiotic use practices for patients seen in the emergency department (ED) and guidance for their implementation. The topics addressed in this guideline are (a) Do biomarkers or rapid pathogen tests improve antibiotic prescribing and

Aerobic Exercise Alleviates Doxorubicin-Induced Cardiotoxicity via Inhibition of Ferroptosis

Introduction: Doxorubicin (DOX), a potent anthracycline, is widely used in cancer therapy, but its effect is limited by doxorubicin-induced cardiotoxicity (DIC). Increasing evidence suggests that DIC is associated with ferroptosis, a cell death characterized by the iron-dependent accumulation of lipid peroxides. Although aerobic exercise is recommended for chemotherapy-related cardiac dysfunction,

Återvinning av renat avloppsvatten för dricksvattenproduktion – erfarenheter från internationella fallstudier

Ett förändrat klimat med mer intensiva regn och längre torrperioder har gjort sötvatten till en alltmer värdefull och sårbar resurs. Vattenbrist förekommer i dag i många delar av världen, även i områden där det tidigare inte varit ett problem, såsom i Sverige. Minskad vattenan-vändning kan bidra till att reducera efterfrågan, men endast upp till en viss gräns. För att säkerställa en långsiktig och

Species-related inhibition of human and rat dihydroorotate dehydrogenase by immunosuppressive isoxazol and cinchoninic acid derivatives

The isoxazol leflunomide (N-(4-trifluoromethylphenyl)-5-methylisoxazol-4-carboxamide) and its active metabolite A77-1726 (N-(4-trifluoromethyl)-phenyl-2-cyano-3-hydroxy-crotonic acidamide) are promising disease-modifying antirheumatic drugs now in clinical trials. The malononitrilamides MNA279 (2-cyano-3-cyclopropyl-3-oxo-(4-cyanophenyl)propionamide) MNA715(N-(4-trifluoromethyl)-phenyl-2-cyano-3-h

Reglering av banker

The subject of this dissertation is the regulation of banks. The enquiry is built around three overreaching research questions:1. What is a bank?2. Why do banks have to be regulated?3. How should banks be regulated? Each of these three questions is dedicated a separate and comprehensive section, each consisting of several chapters. Even though the subject is jurisprudence, the perspective of the

Mer eller mindre byråkratisk : En studie av organisationsförändringar inom Kronofogdemyndigheten

Extensive changes in public organizations have been carried through since the end of the 20th century as a way of achieving higher efficiency. Inspiration came from the private sector. The Swedish Enforcement Authority carried through several organizational changes during this time. The authority was during 1997-2006 organized in ten independent authorities subordinated to the National Tax Board.

The void : Urban wasteland as political space

The rugged field and group of trees between housing estates or next to the railroad tracks, the left-over space of deserted industrial areas, the vacant demolition site of a central city block – they could all be termed ‘urban voids’. However, they are often anything but voids, in a literal sense, as they are not empty, or deserted. Yet they are ‘urban voids’, lacking an evident function, or a def

The intersubjective role of I think constructions in conversation : Combining evidence from corpus and experimental techniques

Combining data from spontaneous face-to-face conversations in the London-Lund Corpus (LLC) of spoken British English and a laboratory experiment, this paper analyses the dynamic nature of I think constructions in dialogue. We make use of the functional category of ENGAGEMENT in APPRAISAL theory as an analytical tool (Martin & White, 2005). More precisely, we examine whether I think constructio

Samhällskunskap för alienerad elit : Observationsstudie av Särskilda läroverket

This thesis is built around an observational study of a class at an elite school. The study follows the class through their upper secondary school education (ages 16-19), focusing on social science lessons. I have used ethnographic methodology to describe and problematize how social science and value-based ambitions of equality conflict with the student role of superiority cultivated at this schoo

Assessing the Inventiveness of Bio-Pharmaceuticals under European and US Patent Law - A comparative study with special emphasis on DNA- and protein-related inventions

“The implications and applications of biotechnology continue to be at the centre of public debate. In the light of rapid scientific advances and novel insights, the multi-faceted discussions are particularly fierce with regard to patents on DNA–related technology. In the often very emotionally-led debate basically two directly conflicting schools of thoughts can be identified. Some people believe

An outline of a Basque computerized grammar

Basque is spoken by approximately 660,000 people (Trask 1997) in the Basque Country, straddling the border between northern Spain and southern France, particularly in rural areas of the Bizkaia and Gipuzkoa coastline, as well as inland Gipuzkoa and the foothills of the Pyrenees in Navarre. Virtually all Basque speakers are bilingual with either Spanish or French. Nevertheless, Basque is, due to it

Mass tourism at a tipping point: Exploring the mediatisation of overtourism

The phenomenon of overtourism encapsulates the spirit of contemporary mass tourism. It has gained attention lately as an unsustainable consequence of the intensification of destination management principles in urban economic planning strategy. Stories about “the invasion” of visitors into a numberof popular European cities frequently circulate in news and social media. Research has begun to examin

Borrowability, inheritance, and semantic change in the Indo-European and Caucasian vocabulary for hunting, farming, and technology

Vocabulary for subsistence and technology may vary a great deal in their degree of borrowability, depending on time, place, inherent subsistence and technology, and the situation of the borrowing. In cross-linguistic typological studies of borrowability, these words tend to group somewhere from middle to high in borrowability, depending on lexical concept (Haspelmath & Tadmor, 2009).We have co

Reprogramming primary melanoma cells to dendritic cell fate enhances tumor immunogenicity

Background Direct cell reprogramming is characterized by the use of defined factors to rewire the transcriptional and epigenetic network of one cell-type into one of a different lineage. We have recently identified the transcription factors PU.1, IRF8, and BAFT3 (PIB) as sufficient to induce a type 1 conventional dendritic cell (cDC1) fate in both somatic and cancer cells.1,2 cDC1 is a rare dendri

Not Just Any Water : Hinduism, Ecology and the Ganges Water Controversy

Popular Abstract in Swedish Gangesfloden i Varanasi (Indien) anses samtidigt vara fullkomligt ren och svårt förorenad, beroende på vem som definierar dess egenskaper, brahminska religiösa specialister eller vetenskapligt orienterade miljöaktivister. Medan kontroversen fortgår, försöker några hinduiska religiösa ledare att anpassa sina traditioner till de nya miljöparadigmen, och deras förhållningsWhether the Ganges river in Varanasi (India) is pristinely pure or heavily polluted depends on by whom it qualities are defined, the Brahmin religious specialists in the city or the science oriented environmentalists. While the controversy continues, some Hindu religious leaders are searching for ways to adjust their respective traditions to the environmental paradigms, an initiative that reflects

Dumb Beasts in Hallowed Tombs : Swedish Funerary Poetry for Animals 1670–1760

The study examines a hitherto neglected genre in Swedish poetry of the 17th and 18th centuries: the animal epitaph. From 1670 to 1760 a considerable number of such poems were composed by several of the leading poets of the day. Besides tracing the history of the genre back to its origins in the ancient Greek epigram, I am chiefly concerned with the functions that the writing of such epigrams had i