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Glutaric aciduria type III is a rare metabolic abnormality leading to persistent isolated glutaric acid excretion. We report the clinical and biochemical phenotypes of three affected children. The first patient is a boy with dysmorphic features and a chromosomal deletion (monosomy 6q26-qter) in whom a persistent glutaric aciduria (500mmol/mol creatinine, normal <10) was detected during a routine m
The Sagittarius dwarf spheroidal galaxy is in an advanced stage of disruption but still hosts its nuclear star cluster (NSC), M54, at its center. In this paper, we present a detailed kinematic characterization of the three stellar populations present in M54: Young metal-rich (YMR); intermediate-age metal-rich (IMR); and old metal-poor (OMP), based on the spectra of 6500 individual M54 member stars
Theory predicts that we should find fast, ejected (runaway) stars of all masses around dense, young star-forming regions. N-body simulations show that the number and distribution of these ejected stars could be used to constrain the initial spatial and kinematic substructure of the regions. We search for runaway and slower walkaway stars within 100 pc of the Orion Nebula Cluster (ONC) using Gaia D
In this work, atmospheric pollutant emissions of NOx, SOx, CO, particulate matter (PM), total organic compounds (TOC), and CO2 from larger stationary sources of pollutants in Brazil were inventoried and spatialized over the whole Brazilian territory for the base year 2011. The developed inventory comprises a total of 16 refining units, 1730 thermoelectric power plants (TPPs), 96 cement industries,
Immune thrombocytopenia (ITP) is an autoimmune disease characterized by enhanced platelet clearance and defective platelet production. Diagnosis by exclusion and trial-and-error treatment strategies is common practice, and despite the advancement in treatment options, many patients remain refractory. Although the existence of different pathophysiological entities is acknowledged, we are still far
During fetal development, mammalian back-skin undergoes a natural transition in response to injury, from scarless regeneration to skin scarring. Here, we characterize dermal morphogenesis and follow two distinct embryonic fibroblast lineages, based on their history of expression of the engrailed 1 gene. We use single-cell fate-mapping, live three dimensional confocal imaging and in silico analysis
Objective: Estimates of pesticide exposure among applicators from low- and middle-income countries (LMICs) are scarce, and exposure assessment methods are sometimes costly or logistically unfeasible. We examined the variability in weeklong pesticide exposure among applicators in Costa Rica and its predictors.Methods: We conducted a cross-sectional survey among 221 pesticide applicators from organi
Paenibacillus larvae, causative agent of American Foulbrood (AFB), is the primary bacterial pathogen affecting honeybees and beekeeping. The main methods for controlling AFB are incineration of diseased colonies or prophylactic antibiotic treatment (e.g. tylosin), neither of which is fully satisfactory. The search for superior means for controlling AFB has led to an increased interest in the natur
Most pathobionts of the respiratory tract form biofilms during asymptomatic colonization to survive and persist in this niche. Environmental changes of the host niche, often resulting from infection with respiratory viruses, changes of the microbiota composition, or other host assaults, can result in biofilm dispersion and spread of bacteria to other host niches, resulting in infections, such as o
BACKGROUND: Although most pediatric radial neck fractures can be treated with either immobilization alone or closed reduction and immobilization, a small subset result in permanent loss of motion despite surgical management. We sought to characterize the most problematic fractures and correlate final outcomes with both presenting fracture characteristics and the reduction achieved through surgical
Aim: This historical prospective cohort study of the adult population of Sweden is based on data from a national registry: the primary aim was to evaluate the long-term survival of teeth after periradicular surgery. A secondary aim was to identify factors predictive of extraction within 10 years of registration of periradicular surgery. Methodology: The cohort consisted of all individuals who had
The emerging debate on transnational populism has thus far mainly focused on cases, which have remained relatively inconsequential due to the weak institutionalisation of the political transnationalism arena. By bringing in a better-structured arena of migrant transnationalism, this paper introduces populist political parties mobilising transnational migrants to the debate and explores the resulti
The formation and evolution of coastal dunes result from a complex interplay of eco-morphodynamic processes. State-of-the-art models can simulate aeolian transports and morphological dune evolution under certain conditions. However, a model combining these processes for coastal engineering applications was not yet available. This study aims to develop a predictive tool for dune development to info
Subband adaptive filters have been proposed to avoid the drawbacks of slow convergence and high computational complexity associated with time domain adaptive filters for acoustic echo cancellation. Subband processing introduces transmission delays caused by the filter bank and signal degradations due to aliasing effects. One efficient way to reduce the aliasing effects is to allow a higher sample
This research will explore the field of social movements by explaining why and how a minority social movement persists despite persistent constraints placed upon it by a majority-dominated state. The Chinese education movement has been one of the largest and most sustained social movements in Malaysia. Sociological, economic, and demographic changes of the Chinese community along with domestic pol
Biological nutrient removal processes for municipal wastewaters have received quite some attention during the past decades, especially due to the introduction of stricter legislation with respect to allowable effluent pollutant discharge limits. The necessity for performance improvement of existing activated sludge wastewater treatment plants (ASWWTPs) has created a need for detailed process model
The use of multi-amplitude signaling schemes in wireless OFDM systems requires the tracking of the fading radio channel. The paper addresses channel estimation based on time-domain channel statistics. Using a general model for a slowly fading channel, the authors present the MMSE and LS estimators and a method for modifications compromising between complexity and performance. The symbol error rate
