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Background: Crucial to the success of clinical trials targeting early Alzheimer’s disease (AD) is recruiting participants who are more likely to progress over the course of the trials. We hypothesize that a combination of plasma and structural MRI biomarkers, which are less costly and non-invasive, is predictive of longitudinal progression measured by atrophy and cognitive decline in early AD, pro

Hierarchical self-assembly is a versatile technique that allows the formation of many complex architectures on the nano- and microscale. However, many of these structures are formed in harsh organic solvents with nonbiocompatible polymers. Here, we investigate in more detail a synthetic path to produce biologically compatible, crosslinked, multicompartment worms (MCWs) in aqueous solution by incor

Definitive hematopoiesis emerges via an endothelial-to-hematopoietic transition in the embryo and placenta; however, the precursor cells to hemogenic endothelium are not defined phenotypically. We previously demonstrated that the induction of hematopoietic progenitors from fibroblasts progresses through hemogenic precursors that are Prom1+Sca1+CD34+CD45- (PS34CD45-). Guided by these studies, we an

Olfaction presents a particularly interesting arena to explore abstraction in language. Like other abstract domains, such as time, odours can be difficult to conceptualize. An odour cannot be seen or held, it can be difficult to locate in space, and for most people odours are difficult to verbalize. On the other hand, odours give rise to primary sensory experiences. Every time we inhale we are usi

In order to improve the selectivity in photocatalytic process, molecularly imprinted photocatalysts containing a low loading of TiO2 (from 6.6 to 16.6% of total mass) were prepared for photocatalytic degradation of an organic pollutant, diclofenac (DIC). The photocatalytic component TiO2 (P25), with and without being doped with Cu2O, was embedded in diclofenac-imprinted polymers. The molecularly i

Over the past 50 years, 210Pb, 137Cs and 241Am have been abundantly used in reconstructing recent sediment and peat chronologies. The study of global aerosol-climate interaction is also partially depending on our understanding of 222Rn-210Pb cycling, as radionuclides are useful aerosol tracers. However, in comparison with the Northern Hemisphere, few data are available for these radionuclides in t

β-1,4-Galactosyltransferase 7 (β4GalT7) is a key enzyme in the biosynthesis of glycosaminoglycan (GAG) chains. Natural and synthetic xylosides can be used to both inhibit and prime GAG synthesis by acting as inhibitors or substrates for β4GalT7. In this report, we exploit hydroxylated oxanes as deoxygenated xyloside analogs to clarify the minimum protein-ligand interactions required for galactosyl

The critical reception should not underestimate the readers, nor overestimate them, but approximate the correct intellectual level. We hear so often the pathetic slogan: "We are the elite"! During modernism, it was known who the elite was; in postmodernism, the elite was sprawled and distributed in honeycombs: even tv anchors perceive themselves as an elite (which the other elites do not know). Na

Advances in sequencing technologies led to rapid increase in the number and diversity of biological sequences, which facilitated development in the sequence research. In this paper, we present a new method for analyzing protein sequence similarity. We calculated the spectral radii of 20 amino acids (AAs) and put forward a novel 2-D graphical representation of protein sequences. To characterize pro

Background: Intermittent androgen deprivation therapy (IAD) is commonly used in prostate cancer because of the benefits of the off-treatment period (OTP). The off-treatment time for patients depends on cancer progression, often measured as a rise in prostate-specific antigen (PSA). Objective: To evaluate if certain factors can predict OTP duration following 7-mo degarelix therapy. Design, setting,

Extreme climate events and nonsustainable land use are important drivers altering the functioning of European ecosystems, resulting in loss of the services provided. Yet a consensus method for regular continental scale assessment of ecosystem condition in relation to land degradation (LD) is still lacking. Here, we propose a new remote sensing-based approach allowing for improved, repeated assessm

The disorders of serine biosynthesis are a group of inborn errors of metabolism characterised by congenital microcephaly, seizures and severe psychomotor retardation. Although these disorders are rare the prompt recognition of serine deficiency is important as these disorders are treatable. The diagnosis is based on decreased concentrations of serine in cerebrospinal fluid (CSF). It has previously

Resonant excitation to the F1s-σ* dissociative state in hydrogen fluoride gives a photoelectron spectrum where the spectator part contains strong atomic lines but a participator part where such lines are lacking. We demonstrate that this contrasting behaviour between the two parts is due to a strong dynamical suppression of the resonant contribution, making direct main state photoionization the do

The peaks arising from the decay of the excited oxygen atom were studied. Fast dissociation of core-excited ozone was confirmed by the presence of Auger emission from atomic oxygen in the decay spectrum from the ozone OT 1s-σ*(7a1) state. No such emission was observed after excitation of the corresponding state on the central oxygen atom. An angle-dependent energy shift of the atomic lines was obs

A new approach to low-complexity channel estimation in orthogonal-frequency division multiplexing (OFDM) systems is proposed. A low-rank approximation is applied to a linear minimum mean-squared error (LMMSE) estimator that uses the frequency correlation of the channel. By using the singular value decomposition (SVD) an optimal low-rank estimator is derived, where performance is essentially preser

In this thesis I focus on soundpainting-mediated musical experiences. Proposed in the mid seventies by the American musician Walter Thompson (b. 1952), soundpainting is a conventionalized artistic practice designed to create artistic works in real time. Thompson’s definition of soundpainting as a sign language is central to the present artistic inquiry, based on different moments of artistic pract