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The human papillomavirus (HPV) life cycle is strictly linked to the differentiation program of the infected mucosal epithelial cell. In the basal and lower levels of the epithelium, early genes coding for pro-mitotic proteins and viral replication factors are expressed, while terminal cell differentiation is required for activation of late gene expression and production of viral particles at the v

Popular Abstract in Swedish Varje dag bildas ca en biljon nya blodceller i en vuxen person. Eftersom blodceller är relativt kortlivade sker denna nyproduktion ständigt. Alla dessa celler härstammar från en sorts cell, multipotenta blodstamceller. Genom en gradvis mognadsprocess, genereras röda blodkroppar (erytrocyter), vita blodkroppar (granulocyter, lymfocyter och monocyter) och blodplättar (troProliferation, differentiation, and survival of hematopoietic stem cells and multipotent progenitor cells are regulated by cytokines and cell-cell interactions. Kit ligand (KL) and Flt3 ligand (FL) have pleiotropic effects, promotes survival, but are nonredundant. Using myeloid progenitor cell lines and mouse bone marrow-derived Lin- progenitors, we demonstrate that inhibition of phophatidylinosit

A new device for stopping or reducing potentially irritating or harmful emissions from surfaces indoors is described. The device is a surface emissions trap prototype and consists of an adsorbent sheet with a semipermeable barrier surrounded by two thin nonwoven layers. The trap may be applied directly at the source of the emissions e.g. at moisture-affected floors and walls, surfaces contaminated

Molecular imprinting technology has been successfully applied to small molecular templates but a slow progress has been made in macromolecular imprinting owing to the challenges in natural properties of macromolecules, especially proteins. In this review, the macromolecular imprinting approaches are discussed with examples from recent publications. A new molecular imprinting strategy, microcontact

Fluorinated quinolones exert their bactericidal activity by inhibiting bacterial type II topoisomerases. At therapeutic concentrations, quinolones superinduce interleukin-2 (IL-2) and interferon-gamma production by mitogen-activated human peripheral blood T lymphocytes. At the molecular level, a stronger activation of the nuclear factor AP-1 ('activator protein-1') is observed in cells incubated w

This paper deals with Kripke’s influential criticism of the view that mental states are physical in nature, i.e. that such states are identical with certain physical states or processes.

Popular Abstract in Swedish Under 1900-talet har jordbruket förändrats drastiskt. Från ett småskaliga lantbruk där åkrar, ängar och betesmarker avlöste varandra, och varje gård var beroende av att både odla mat och hålla djuren med foder, till ett allt mer specialiserat jordbruk där både de enskilda gårdarna och hela regioner specialiserat sig mot antingen spannmålsproduktion eller djurhållning. OAs a consequence of agricultural intensification, large areas of non-crop habitat have been lost and farmland biodiversity has declined. Previous studies have shown that the extent of non-crop habitat influences farmland biodiversity, but the relative importance of different habitat types is less well known and the contribution of small incidental habitats to landscape-scale species richness is no