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Parkinson's disease (PD) is characterized by dopaminergic neurodegeneration, α-Synuclein (α-Syn) pathology, and inflammation. Microglia in the substantia nigra pars compacta (SNpc) upregulate major histocompatibility complex class II (MHCII), and variants in genes encoding MHCII affect PD risk. Additionally, elevated TNF levels and α-Syn-reactive T cells in circulation suggest a strong link betwee

Low birthweight is a risk factor for type 2 diabetes. We hypothesised that differential associations between birthweight and clinical characteristics in persons with and without type 2 diabetes may provide novel insights into the role of birthweight in type 2 diabetes and its progression. We analysed UK Biobank data from 9,442 persons with and 254,446 without type 2 diabetes. Associations between

Introduction In type 2 diabetes (T2D), beta cell failure is often associated with islet inflammation driven by the innate immune response, with macrophages playing a significant role. However, the composition and phenotype of lymphoid immune cells in the islets of individuals with T2D have not been extensively studied. This study aims to characterize and compare the presence, phenotype, and freque

TAR DNA-binding protein 43 (TDP-43) pathology is linked to the neurodegenerative disorders amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD) and Huntington disease (HD). Dysregulation of metabolism and emotion is shared across these disorders and may be caused by hypothalamic pathology. Inclusions with TDP-43 are present in the hypothalamus in clinical ALS, as well as selective lo

BACKGROUND: Mental health service users often experience difficulties interpreting and regulating sensory stimuli resulting in increased anxiety, decreased abilities to engage in activities and a hampered recovery process. However, there are limited studies on the implementation of such recovery-oriented interventions targeting sensory difficulties via sensory modulation techniques. Therefore, the

Urban environments are exposed to a substantial range of anthropic pressures, including chemical exposure. While trace metals and legacy pollutants have been well documented, the extent of wildlife exposure to emerging contaminants has received little attention, in terrestrial mammals. Concentrations of trace elements (Ag, Al, As, Cd, Co, Cr, Cu, Fe, Mn, Pb and Zn) and 48 organic pollutants (Polyc

The purpose of this thesis is to investigate different scales of mobility and social networks in Southern Scandinavia around 7000 BC. An essential basis for this work is the hypothesis that the conical core pressure blade technology, a specific method for producing lithic blades, reached Scandinavia from the east. The process has been discussed and verified in several earlier studies.The study is The purpose of this thesis is to investigate different scales of mobility and social networks in Southern Scandinavia around 7000 BC. An essential basis for this work is the hypothesis that the conical core pressure blade technology, a specific method for producing lithic blades, reached Scandinavia from the east. The process has been discussed and verified in several earlier studies.The study is

BACKGROUND: A history of hypertensive disorders of pregnancy is associated with at least twice the risk of incident ischemic heart disease. Whether the long-term outcome following treatment with coronary artery stenting is associated to the history of hypertensive disorders of pregnancy is unknown. METHODS AND RESULTS: We included 8364 women (age ≤65 years) undergoing first coronary artery stentin

BACKGROUND & AIMS: The role of early-life overall diet in celiac disease risk is not well explored. The aim was to investigate associations of dietary diversity, and healthy eating in the second year of life with subsequent celiac disease risk.METHODS: In 64,315 children born 2002-2009 with available data in the Mother, Father and Child Cohort Study, a Dietary Diversity Score (0-4) and Healthy

Description: Early interventions with PMDs can improve the independence and developmental outcomes of children with disabilities. Increasing awareness and interdisciplinary collaboration are essential to overcome barriers to access to PMDs. Expanding global partnerships and integrating PMDs into clinical and educational settings can increase children's access to mobility. ABSTRACT: Background The Description: Early interventions with PMDs can improve the independence and developmental outcomes of children with disabilities. Increasing awareness and interdisciplinary collaboration are essential to overcome barriers to access to PMDs. Expanding global partnerships and integrating PMDs into clinical and educational settings can increase children's access to mobility. ABSTRACT: Background The

Background Suicide attempts are common in youth and have potentially lethal outcomes. Effective treatments targeting suicide attempts are scarce. Objective To assess the feasibility and preliminary efficacy of a family-based cognitive behavioural treatment relative to an active control for youth with suicidal behaviour. Methods 30 youths (93% female; mean (SD) age=14.6 (1.5) years) residing in Swe

Purpose: In a multicenter prospective cohort study, we assessed the diagnostic yield of the Nordic guidelines for germline investigation in myeloid neoplasms and mapped the spectrum of inherited and somatic variants. Experimental Design: Eighty-five patients (acute myeloid leukemia, n = 38; myelodysplastic syndromes, n = 26; thrombocytopenia, n = 14; and other, n = 7) fulfilling the Nordic criteri

Background and Aims: Previous studies have shown that procalcitonin (PCT) concentration is elevated in patients with liver disease without evidence of bacterial infection. We aimed to investigate the association between elevated PCT and the future risk of liver disease. Method: PCT was measured in 3897 individuals without known liver disease in the Malmö Diet and Cancer Cardiovascular Cohort (MDC-

BACKGROUND AND AIMS: Adhering to the EAT-Lancet diet has been observed to be associated with lower risks of various morbidities. This study aimed to investigate the association of adhering to the EAT-Lancet diet with incident chronic obstructive pulmonary disease (COPD) and identify plasma proteins mediating such association.METHODS: This prospective study involved 202 340 participants free of COP