Filetype
Pulmonary arterial hypertension (PAH) is a life-threatening condition with no cure, making research into its underlying mechanisms critical. The platelet-derived growth factor (PDGF) signaling pathway plays a crucial role in vascular remodeling, a key factor in PAH progression. Anti-PDGF receptor therapies, such as imatinib, show promise but are associated with significant side effects. Recent res
AIMS: Vascular atherosclerotic calcification is a pathological process marked by the abnormal deposition of calcium minerals in the intima. Asporin (ASPN) is a small leucine-rich proteoglycan which interacts with collagen and calcium. Due to its role in matrix mineralization, we hypothesized that ASPN might act as a regulator of vascular calcification, thereby promoting atherosclerotic plaque stab
Registry-based randomised controlled trials (R-RCTs) represent a paradigm shift in research, with the potential to accomplish pragmatic but large trials with high external validity. In this paper, we review our experiences from planning and performing the REgistry-based randomised controlled trial of treatment Duration and mortality in long-term OXygen therapy (REDOX) trial, the first R-RCT within
Individuals with immigrant background generally perform less well in school than non-immigrants. Performing well in school may decrease the risk of substance use disorder (SUD). We investigated whether higher school performance is associated with a decreased risk of SUD in early adulthood among immigrants and non-immigrants and whether subsequent educational attainment and employment status partly
BACKGROUND: Balloon-guide catheters (BGC) have been associated with improved procedural and functional outcomes following endovascular thrombectomy (EVT) in multiple observational studies. Recently the PROTECT-MT trial challenged this benefit, showing worse functional outcomes when using BGCs. This study aims to assess the association between BGC-use and procedural and functional outcomes in a lar
Objective: To design a dynamic prediction model for estimating the time of progression from a single glutamic acid decarboxylase autoantibody (GADA) to multiple islet autoantibodies and type 1 diabetes in children, exploring different longitudinally measured risk variables. Research Design and Methods: GADA-positive children (n = 379) participating in The Environmental Determinants of Diabetes in
BackgroundMonogenic insulin resistance (IR) includes lipodystrophy and disorders of insulin signalling. We sought to assess the effects of interventions in monogenic IR, stratified by genetic aetiology.MethodsSystematic review using PubMed, MEDLINE and Embase (1 January 1987 to 23 June 2021). Studies reporting individual-level effects of pharmacologic and/or surgical interventions in monogenic IR
INTRODUCTION: Ulnar nerve entrapment (UNE) is a common disorder with many associated risk factors. Diabetes mellitus (DM) is an established risk factor, but less is known about metabolic risk factors in individuals without diabetes. Our study aimed to explore the association of body mass index (BMI) with UNE during long-term follow-up.METHOD: The population-based cohort study Malmö Diet and Cancer
Volcanic eruptions can have severe societal and environmental impacts as shown by ash dispersal and sulphur emissions from recent Icelandic eruptions. However, ice-core sulphur records demonstrate that these events were minor as compared to eruptions of much larger magnitude in recent centuries, with severe implications for past society documented in historical records. Biological and chemical evi
Background and aims: Heart transplantation is the preferred treatment for selected patients with end stage heart failure. Kidney function often declines after heart transplantation. Sodium-glucose cotransporter 2 inhibitors (SGLT2i) slow the decline in eGFR in different populations. However, the effect of SGLT2i on kidney function in heart transplant recipients is unknown. Methods: The Dapaglifloz
Background: Celiac disease is associated with HLA-risk haplotypes, but non-HLA genes and environmental factors are also linked to disease susceptibility. In this study, we explore the molecular pathways involved in celiac disease by analyzing the differential expression of genes in both the gut and peripheral blood across various celiac disease phenotypes. Methods: Whole genome RNA sequencing was
Introduction: Alcohol use has significant health implications, yet the association between alcohol use and respiratory symptoms remains relatively understudied. This study examines the prevalence of hazardous alcohol use and its associations with breathlessness, chronic cough, and health-related quality of life (HRQoL) and whether these associations with chronic airway limitation (CAL) differ by a
BACKGROUND: Selective glomerular hypofiltration syndrome (SGHS), formerly shrunken pore syndrome, an emerging marker of glomerular dysfunction, is associated with worsened prognosis in cardiovascular disease, but its role in kidney failure remains underexplored. Osteopontin (OPN) is associated with worsening kidney function and prognosis in chronic kidney disease.PURPOSE: To explore if increased l
Background: Physiologically guided revascularization improves clinical outcomes. The cutoff values for deferral with fractional flow reserve (FFR) and instantaneous wave-free ratio (iFR) are the same across all coronary arteries, despite differences in coronary flow patterns. The objective was to compare deferral rates using either FFR or iFR in the right coronary artery (RCA), left anterior desce
Type 1 diabetes, formerly known as juvenile diabetes or insulin-dependent diabetes, results from the specific autoimmune destruction of the pancreatic islet beta cells. The subsequent loss of insulin leads to increased blood and urine glucose. The classical symptoms are polyuria (frequent urination), polydipsia (increased thirst), polyphagia (increased hunger), and weight loss. The disease may be
Context In most cases of non-islet cell tumor hypoglycemia (NICTH), high molecular weight forms of insulin-like growth factor II, commonly referred to as big IGF-II, cause hypoglycemia. MicroRNA-483 (miR-483), encoded within an intron of IGF2, has been suggested to be coexpressed with IGF-II. Objective The aim of this study is to demonstrate the utility and reliability of circulating miR-483 as a
Aims: Social science literature suggests that unlimited trust in others may lead to adverse outcomes, and that moderate trust may be more optimal in social interactions. The aim was to analyze associations between generalized trust in other people and all-cause mortality using a four-alternative generalized trust item that includes moderate trust. Study design: Prospective cohort study. Methods: T
