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Increased expression of the cell cycle regulatory protein cyclin A1 has previously been detected in patients with acute myeloid leukemia (AML) and targeted overexpression of cyclin A1 in a transgenic mouse model initiated AML. The aim of this thesis was to further study the expression and regulation of cyclin A1 in hematopoietic cells. We started with evaluating the subcellular localization of cyc
This book presents an exhaustive and systematic investigation of six representatives of three important periods of New Testament interpretation: Martin Luther, John Calvin, Brooke Foss Westcott, Heinrich Julius Holtzmann, Rudolf Bultmann and Raymond E. Brown. They serve as dialogue partners in an investigation of the notion of God in the Fourth Gospel, a topic that has been called “the neglected f
The overall aim of this study is to describe a number of different uses of the French "seul" and "seulement", and to account for the observed differences within a generative framework. After an introductory chapter, chapters two and three present a survey of earlier studies. The fourth chapter concerns an empirical study of authentic occurrences of "seul" and seulement", drawn from the press. The
The life cycle of electronic products is associated with significant environmental impacts. Compared to many other products, the production of electronics and in particular semiconductors is resource intensive and generates a number of highly toxic waste streams in manufacturing and post-consumer stages of product life cycle. Electronics manufacturing industry has been successful in reducing envir
This dissertation analyzes the work on universal morality by the Swiss theologian Hans Küng. According to Küng, a universal morality can be formed out of the world's religions that can reconcile ideological, cultural and religious differences. This morality can then form the basis for international policy and politics and guarantee that relations among states are peaceful. Küng's project focuses
Antibiotic resistance is now a large threat with worldwide agreement that we will fall into a post-antibiotic era unless there is suitable treatment alternatives discovered. In recent years, chronic wounds have become a major burden on society and treatment is complicated. Honey has been widely used as a topical treatment for wounds yet there is much discourse between studies examining its effect
Precise spatial and temporal regulation of gene expression programs is a prerequisite for multicellular life. Since the discovery of DNA as the carrier of genetic information, a key question in biology has been how these hard coded instructions are read and regulated to maintain cellular and organismal homeostasis. Understanding the mechanisms and processes governing gene and genome regulation are
The interaction between poylions and oppositely charged surfactant ions has been investigated. This has been done by using the pure complex salt (polyion + surfactant ion) as a point of departure. Different parameters of the complex salt have been varied in a systematic way and the effect on structure and water miscibility has been investigated. Complex salts (CxTAPAy) consisting of alkyl trimethy
Melanin is an epidermal pigment commonly known to give darker skin coloration under sun exposure. It is also present in the hair, eyes, inner ear and brain. The first function of epidermis melanin is believed to be photoprotective against harmful ultraviolet (UV) light, but the recent increase of skin cancer correlated to an increase of sun exposure questions the properties of melanin. Its presenc
The outcomes of 20 patients participating in occupational group therapy at a psychiatric outpatient unit were explored and related to perceptions of the ward atmosphere and the treatment process. The outcome variables - psychiatric symptoms, global mental health, quality of life, and occupational functioning - were measured at admission, at discharge, and 1 year after discharge. The ward atmospher
Many of the drugs that are developed in the pharmaceutical industry have their origin in natural products. Paclitaxel, the active substance of the medicine Taxol, was found in the bark of the Pacific yew tree (Taxus brevifolia). This was discovered in the early 1960's when a screening program was initiated by the National Cancer Institute (NCI) in the US, with the aim to find new natural products
The three parts of this thesis are different examples of utilization of signal dependent basis functions in the estimation procedure. The first part surveys a number of parametric methods applied to estimation of single ERP (P300). The basis functions of the sERP are the damped sinusoids where the frequency and damping factor are estimated from the signal. The algorithms for white noise disturban
A new method for allylation of aromatic systems has been developed. A number of arylamines were converted via diazotization to the corresponding allylaromatic compounds using tert-butyl nitrite and an excess of allylic bromides with complete regioselectivity. Electron-withdrawing groups, in the aromatic moiety, were necessary to obtain good yields. The convenient experimental procedure allowed the
A series of experiments and developments, related to stable and radioactive isotopes, have been carried out. These studies have focused on measuring the low-lying excitations of spherical and deformed nuclei using electromagnetic (Coulomb) excitation and also on developments in detector technology for upcoming radioactive ion beams facilities. The low-lying excitations in the nuclei 107,109Sn and
The complexity of proteins is reflected in the structure of their fluids. This is seen from strongly inhomogeneous distributions about the single protein. Using molecular simulations of protein models, based on experimental structures, the present work probes the directional forces between proteins. Emphasis is made on the mutual orientation of proteins and the interplay of electrostatic and short
Melatonin is a neurohormone which mediates photoperiodic signals from the pineal organ to the brain. GABA (g-aminobutyric acid) is the major inhibitory transmitter in the central nervous system. It has previously been suggested that functional interaction exists between central binding sites for GABA/benzodiazepines (GABAA/bzd receptors) and melatonin in the central nervous system, and that GABA a
The respiratory chain of plants contains both proton-pumping enzymes that conserve energy and non-proton-pumping alternative enzymes that bypass the sites of energy conservation. In addition to the proton-pumping complex I, plant mitochondria contain alternative type II NAD(P)H dehydrogenases, which allow oxidation of NADH and NADPH from the matrix and the cytosol. The seven gene homologues of typ
