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In this thesis different aspects of gel free procedures for mass spectrometry based proteome analysis are addressed, with emphasis on labelling techniques. It is based on three original articles where the effects imposed onto peptides upon modification are investigated, and the development of a new type of labelling strategy is described. Chemical modification has been of great importance for the
The aim of this thesis is to examine interaction between the business community and academia, and consider the Science Park as a brokering environment and actor. The bulk of park-oriented research, like park-related practice, is based on network theory and thinking. Taking such an approach, it is natural to study the intensity and nature of the interactions of the involved parties – in this case,
The main purpose of the performed research presented in this thesis is to increase the understanding of the effect of variability of strength properties on the reliability of timber structural systems. Compared to other structural materials such as steel and concrete, structural timber has a considerably higher variability of strength both within and between members. The advantage of the low proba
A harmonic morphism is a map between two Riemannian manifolds with the property that its composition with a local harmonic function on the codomain is a local harmonic function on the domain. Such a map is automatically a harmonic map, satisfying an additional partial conformality condition called horizontal (weak) conformality. In local coordinates, this amounts to a non-linear, over-determined s
This dissertation is a historical-comparative analysis of a conflict that has developed in the economic system of the Miskito in the 20th century, concerning the use of common property resources. The study is based on empirical material collected in a Miskito/Creole village on the Atlantic Coast of Nicaragua in the 1990s. During the enclave period (1860-1960) Miskito men earned money as wage labou
This thesis is about dynamics of piecewise hyperbolic maps on bounded sets in the plane and on the interval. It is based on the following papers: T. Persson, A piecewise hyperbolic map with absolutely continuous invariant measure, Dynamical Systems: An International Journal, 21:3 (2006), 363--378 T. Persson, Absolutely continuous invariant measures for some piecewise hyperbolic affine maps, Prep
This discourse is constituted by two separate reprots, where the first one offers an elementary deduction of the leading order term asymptotics for the Titchmarsh-Weyl M-function corresponding to a vector-valued Sturm-Liouville equation of the form -(PU')'+QU=zu, xin[0,b), with P^{-1},W,Q being hermitean with locally integrable entries; and under some additional conditions on P^{-1} and W. In the
The central topics of the thesis are autobiographical memory and metaphors. Three hypotheses are presented: (1) Autobiographical memory is better understood without dichotomizing the declarative (explicit) long-term memory system into semantic and episodic. An alternative model is proposed in which semantic and autobiographical memory are overlapping and the recollective memory is regarded as a me
What role the state should and can play in bringing about economic development is one of the longest standing debates in the economic sciences. Yet, previous research has mostly focused on how a variety of industrial policies affect static efficiency. Few studies have tried to analyze how industrial policy and government intervention affects dynamic efficiency, i.e. an economy's ability to generat
The aim of the present work was to gain better understanding of the mechanisms controlling heat and mass transfer during thermal processing of beefburgers. The effects of different factors such as the chemical composition and comminution of the meat raw material, the pan temperature and the meat patty diameter on the characteristics of heat and mass transfer were studied. The evolution of the char
The development in society and school activities that have taken place during the past twenty years, form the background to the problem in this thesis. Liberal democratisation in the society as a whole and the global explosion of knowledge have made it necessary for teachers continuously to develop new knowledge. The over all aim of the thesis concerned the development of knowledge of variations
The analysis of the recorded electrical activity of the heart during an exercise test is a valuable method for investigating a patient's circulatory and respiratory system. But the disturbances that occurr during a test often make it difficult to interpret the signal in order to detect changes evoked by the increased workload and related to for instance coronary artery diseases. Suppression of dis
The pedigree of the elements heavier than iron is a vital question in the history and evolution of our galaxy. The elements up to and including those of the iron group are produced mainly through fusion processes within stars, giving the stars their energy. The even heavier elements are instead mainly produced through neutron capture processes: weak s-process, main s-process and r-process. The wea
The final step in aerobic respiratory pathways is catalyzed by terminal oxidases. Bacteria generally have two or more terminal oxidases. Aerobically grown Bacillus subtilis synthesize three terminal oxidases: one cytochrome c oxidase, cytochrome caa3 and two quinol oxidases, cytochrome aa3 and cytochrome bd. In addition, a fourth cytochrome of bd-type has been predicted from the genome sequence. C
With the discovery of antibiotics, several diseases that were previously lethal is today readily cured, or so we thought. Some degree of resistance to one or several antibiotics can be found among many strains of clinical important bacteria. The problem has been somewhat kept at bay for the last few decades by altering already existing antibiotics, and thereby prolonging their usage. It is clear t
Synthesis and characterization of new transition metal carbonyl clusters has been undertaken, and evaluation of the new clusters to act as catalysts/catalysts precursor in asymmetric reactions has been carried out. The catalytic hydrogenation of tiglic acid under relatively mild conditions, using diastereomeric clusters of the general formula [(µ-H)2Ru3(µ3-S)(CO)7(µ-1,2-L)] (L= chiral diphosphine
Dyes are commercially indispensable and the expanding industry offers a complete palette of colors. Azo dyes constitute the largest chemical class of synthetic dyes because of their versatility, low price, and ease of production. These dyes may, however, pose health risk to humans due to formation of mutagenic/carcinogenic aromatic amines upon reductive cleavage of their azo groups (-N=N-). Theref
Diffusion MRI is widely used to study brain structure in vivo. While this technique is often applied to investigations of brain connectivity, it can also be used to infer specific information about the tissue microstructure; for example, to estimate the axon diameter. In the present work, the role of tissue microstructure and water exchange in biophysical models employed in diffusion MRI was inves
This thesis is a study of a particular limestone votive statuary type which was dedicated in the sanctuaries on Cyprus during the entire 6th century B.C. Common to the group of figures is that they are wearing a Cypriote version of an Egyptian-type outfit, including characteristic Egyptian royal headgear and jewelry. In order to be able to answer questions on the origin of the Egyptianizing iconog
Complex I is the mitochondrial enzyme complex that oxidizes NADH produced in the citric acid cycle and reduces quinone in the membrane, coupled to proton pumping out of the mitochondrial matrix, creating a membrane potential. This process generates about 40% of the energy used by living organisms. High-resolution structures of complex I recently became available, but the molecular mechanism behind
