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Uncontrolled proliferation and invasion are two characteristics in tumour development and progression. Previous studies have shown that invading tumour cells in colorectal cancer have low proliferation in parallel to upregulation of the tumour suppressor p16. We set out to detail the p16 expression and proliferation in basal cell carcinoma and squamous cell carcinoma of the skin, tumours that are
This thesis consists of an introductory chapter and four research papers, summarized as follows. The overall purpose is to study various external effects of the transport system; effects that are not considered (or not fully considered) today. The first paper estimates the relationship between accident frequency and homogeneous and inhomogeneous traffic flows, which is useful for calculating the
The Grammar of The Hype digital information technology -IT- in retelling as myth its experienced reality and in scientific analysis or the IT-hype in the years prior to and at the turn of the millennium waiting for the next hype and the next, and“next”... This is the title of my thesis and it focuses rather on a particular “hype” than deals with the so-called information society as such. What is
For the sacrifice shelamim in the Hebrew Bible, scholars have suggested a number of different interpretations and uses. This sacrifice also had an ambiguous role in Israelite culture. Lack of a general consensus and the failure to reach a satisfying solution makes the shelamim a puzzle and an interesting sacrifice to investigate with insights gained from modern ritual studies. In this study, it i
The main purpose of this thesis is to examine the impact of social change on Chinese intergenerational relations in contemporary Singapore. Within only three decades, Singapore has turned into a wealthy and sophisticated metropolis with a highly educated labor force. The massive transformation, however, has been accompanied by the emergence of a deep and complex generation gap. Apart from the leap
The aim of this dissertation is to explore some of the problems associated with introducing authentic assessment in teacher education. In the first part of the dissertation the question is investigated, through a literature review, whether the use of scoring rubrics can aid in supporting credible assessment of complex performance, and at the same time support student learning of such complex perfo
Policies based upon Extended Producer Responsibility (EPR) aim to reduce the environmental impacts of products across their entire life cycle. The intent is to induce design changes in products and thus reduce impacts at source. This, by provision of incentives to producers through an extension of responsibility. Since the early 1990s, a number of countries have incorporated the concept of EPR int
The aim of this thesis is to analyse the status of new stained glass from 1851-1955. The point of departure is that, despite stained glass having been part of the ?uvre of many well-known artists, it is often not included in the general history of art. One primary methodological approach is to examine the issue of status emerging from notions of the media-specific qualities of stained glass. The
The neurotrophins, notably brain-derived neurotrophic factor (BDNF) and neurotrophin 3 (NT3), modulate synaptic transmission and synaptic plasticity in the adult mammalian brain. Recent data suggest that neurotrophins might be mediators of activity-dependent synaptic plasticity. Such plasticity is believed to be a cellular correlate for important processes like learning, but also for diseases, for
Cervical radiculopathy is diagnosed by history, clinical examination of the patient and magnetic resonance imaging (MRI) of the cervical spine. In many of the patients undergoing this diagnostic strategy, the nerve root/roots responsible for the radicular pain is difficult to define as clinical examination and MRI investigation does not provide information enough. The information from transforamin
Microemulsions are thermodynamically stable, transparent solutions of water, oil and amphiphile(s). It is possible to incorporate large amounts of oil in microemulsions, which makes them interesting for use as a drug delivery vehicle for water insoluble drugs. A prerequisite for pharmaceutical use, however, is a low toxicity of the composition. The aim of this thesis has thus been to characterize
This thesis presents contributions to structure-and-motion estimation, a central topic in the field of geometric computer vision. In particular, the problem of view planning is considered, and continuous and discrete optimization-based algorithms are given for how to plan the path of a sensor to its destination, while balancing the competing goals of path length and reconstruction accuracy. The sa
Nowadays, more than 90% of our energy comes from combustion processes. Hence, it is very important to perform combustion research to reduce emissions, improve efficiency, find clean and renewable fuels, strengthen safety, etc. The complexity of combustion processes asks for advanced diagnostic tools, among which the laser spectroscopy has been proved to be a powerful one. This thesis is about the
The development of a miniaturised silicon wafer integrated enzyme reactor is described. The reactor was micromachined by anisotropic wet etching of (110) silicon. The enzyme glucose oxidase (GOx) was coupled to the reactor surface with standard methods of immobilising enzyme to silica. The glucose turn-over rate was monitored following a colourimetric assay. The advantage, in terms of high surface
Abstract: This thesis consists of four papers related to various aspects of water waves with vorticity. Paper I: Symmetry of steady periodic gravity water waves with vorticity. We prove that steady periodic two-dimensional rotational gravity water waves with a monotone surface profile between troughs and crests have to be symmetric about the crest, irrespective of the vorticity distribution wit
Cystatins are endogenous protease inhibitors that regulate the proteolytic activities of family C1 (papain-like) cysteine proteases, such as human cathepsins B, H, K, L, and S. Cystatin C shows the fastest inhibition and the highest affinity of all cystatins towards lysosomal cysteine proteases in general and is widespread in human tissues and body fluids. Alterations in the balance between the cy
Syftet med detta examensarbete är att undersöka vad som får svenska pensionärer att migrera till Costa del Sol och hur det påverkar deras uppfattning om deras existentiella hälsa som uttryckt i mening-i-livet, sammanhang och tillit. Uppsatsen bygger på ett två veckor långt fältarbete, med observationer, samtal och ett kort frågeformulär. Den övergripande forskningsfrågan är hur migrationen har påv
