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Background: Extraordinary progress has been made in our understanding of common variants in many diseases, including melanoma. Because the contribution of rare coding variants is not as well characterized, we performed an exome-wide, gene-based association study of familial cutaneous melanoma (CM) and ocular melanoma (OM). Methods: Using 11 990 jointly processed individual DNA samples, whole-exome
This dissertation deals with memory, recognition and solidarity in the Nowa Huta district of Kraków, Poland. Nowa Huta was founded as an independent, socialist model town in 1949, together with the large Lenin Steel Plant, and was incorporated into Kraków in 1951. In the 1980s the steel plant and district became one of the main centers of the oppositional Solidarity movement in Poland. Situated be
Background: Most validations of paediatric glomerular filtration rate (GFR) estimating equations using standardized creatinine (CR) and cystatin C (CYS) assays have comprised relatively small cohorts, which makes accuracy across subgroups of GFR, age, body mass index (BMI) and gender uncertain. To overcome this, a large cohort of children referred for GFR determination has been established from se
Background: Quality of life (QOL) has become an important complementary endpoint in cancer clinical studies alongside more traditional assessments (eg, tumour response, progression-free survival, overall survival). Niraparib maintenance treatment has been shown to significantly improve progression-free survival in patients with recurrent ovarian cancer. We aimed to assess whether the benefits of e
Solid insulin formulations obtained by different methods of preparation were compared with respect to chemical stability and morphology. Spray- and freeze-drying, solution enhanced dispersion by supercritical fluids (SEDS) and precipitation into starch microspheres were the methods used for preparation of solid powders. The excipients applied were melezitose, starch, and sodium taurocholate. The s
The stability of dispersions containing charged particles may obviously be regulated by salt. In some systems, the effective charge, as measured by the potential some small distance away from the particles, can have a sign opposite to the bare surface charge. If charge reversal takes place, there is typically a salt concentration regime within which colloidal stability increases with added salt. T
Introduction: The purpose of this study was to investigate neurological disorder as a risk factor for dislocation following arthroplasty for acute hip fractures. We also analysed medical and surgical adverse events (AE), readmission, reoperation, revision, and mortality as secondary outcomes. Methods: A longitudinal cohort study using prospectively collected and aggregated data from the Swedish Hi
The objective of this study was to extract the rapeseed protein from by-products and further examine the effect of lab-made rapeseed protein on the droplet size, microstructure, colour, encapsulation and apparent viscosity of emulsions. Rapeseed protein-stabilised emulsions with an increasing gradient of milk fat or rapeseed oil (10, 20, 30, 40 and 50%, v/v) were fabricated using a high shear rate
Robust and rapid xylose utilization is essential for developing sustainable bioprocesses capable of converting pentose-rich lignocellulosic biomass into renewable chemicals. Saccharomyces cerevisiae is a popular choice for industrial bioprocesses due to its high product yields, robust performance, and stress tolerance. Unfortunately, S. cerevisiae does not natively utilize xylose. Decades of resea
Artikel 6 i Europakonventionen tillförsäkrar var och en rätt till en rättvis rättegång. I artikel 6.2 kommer oskyldighetspresumtionen till uttryck. Oskyldighetspresumtionen innebär att varje individ ska betraktas som oskyldig till dess att motsatsen är bevisad. Av detta följer att åklagaren bär bevisbördan och att den tilltalade har rätt att förhålla sig passiv. Samtidigt förekommer så kallade förPursuant to Article 6 of the European Convention on Human Rights everyone is entitled to a fair trial. Article 6.2 of the Convention stipulates the legal principle of the presumption of innocence, ensuring that everyone charged with a criminal offence shall be presumed innocent until proved guilty according to law. As a result of the presumption of innocence, the burden of proof is on the prosecut
Den svenska rättsstaten står inför allvarliga prövningar. Det grova våldet till följd av skjutvapen har ökat markant i Sverige, och risken för tredje man att drabbad av skjutningar och detonationer på offentlig plats har ökat. Samtidigt som våldet även blivit mer hänsynslöst och likgiltigt. Antalet brott inom denna kategori ökar, men uppklaringsandelen är låg. En förklaring till den dystra statistThe Swedish rule of law is facing serious challenges. The use of firearms resulting in severe injury has increased significantly in Sweden, and the risk of third parties being affected by shootings and detonations in public places has increased. At the same time, the violence has become more ruthless and indifferent. While this type of violence is increasing, law enforcement agencies are at a loss
A plant’s rain coat Imagine yourself taking a walk on a cloudy day. Suddenly, the sky opens and the rain is pouring down making you totally soaked. Now imagine that you predicted that it would start to rain so you put on a rain coat. When the rain starts to fall, you won’t get wet since the rain drops will strike against the rain coat and get drained. In the same manner, the wax on plants is prot
Under det senaste seklet har det svenska samhället utvecklats från att ha varit ett industrisamhälle till att bli ett kunskapssamhälle. Denna utveckling har inneburit att s.k. kunskapsföretag har kommit att få en alltmer central roll i samhället. Kunskapsföretag kännetecknas av att de främst bedriver kunskapsproduktion och inte materiell produktion. Det är de anställdas kunskap som utgör kunskapsfDuring the last century, the Swedish society has developed from being an industrial towards becoming a knowledge-based society. As a consequence, so-called knowledge management-companies have come to occupy a central role in society. Knowledge management-companies ́ primary production is knowledge and not matter. Since the employees possess the knowledge, they are the most valuable resources of th
Uppsatsen behandlar den rättsliga hanteringen av personlig och sexuell integritet i dagens samhälle. Den utreder även det särskilt skyddsvärda i den sexuella integriteten. Uppsatsen grundar sig i en teori om att sexualbrott är starkt förknippade med kön, makt och sexualitet där offret oftast är en kvinna och gärningsmannen en man. Därför anlägger uppsatsen ett feministiskt perspektiv. Uppsatsen This essay focuses on personal and sexual integrity and how they, as two protective interests, are dealt with in the legislation process and in criminal law in general in today’s society. It especially focuses on the specific characteristics of sexual integrity and sexual crimes. The essay is based on a theory that sexual crimes are strongly connected to gender, power and sexuality where the victi
During the past few years the focus on bioprocess monitoring and control has increased. An area still under intensive development is the sampling methods for efficient and rapid analysis during fermentations. In this thesis, an online-sampling and monitoring scheme was developed using the versatile automated continuous flow system (VersAFlo) for recombinant protein production. From the implementat
För att förutsäga beteendet hos mekaniska dynamiska system används beräknings-modeller som utgår ifrån systemens massa, styvhet och dämpningsegenskaper. Dessa modeller kan vara avancerade eller lätthanterliga mycket beroende på hur dämpnings-mekanismerna modelleras. Syftet med arbetet var att undersöka hur mer avancerade materialmodeller för beskrivning av dämpningen påverkar systemets dynamik.Damping is present in all dynamic systems. In one way or another energy is being dissipated in the system. To capture this aspect of reality in a computational model is a difficult task. A common simplification is to assume that the damping is of a linear viscous nature. This assumption provides an equation of motion (linear dynamics) which is easy to handle mathematically. However, the simplicity of
What makes a beetle attractive? My project looks at how green tortoise beetles (Cassida viridis) choose partners, and which physical traits have a higher success in obtaining a mate. I did this by tracking individuals in three wild populations of Skåne, Sweden, and taking photographs of mating beetles. To document differences between the sexes and populations, see how many partners a beetle has,
Samhället har ett intresse av att skydda barn från att komma till skada när de växer upp under farliga förhållanden. Barns exponering för våld och övergrepp kan få allvarliga konsekvenser för barnets hälsa och utveckling. Bestämmelserna som reglerar vårdnad, boende och umgänge finns i 6 kap. föräldrabalken (1949:381). Barnets bästa ska vara avgörande vid alla beslut som rör barn. Vid domstolens Society has an interest in protecting children from harm when they grow up under dangerous conditions. Children’s exposure to violence and abuse can have serious consequences for the child’s health and development. The regulations regarding matters of custody, the residence of the child and visitation rights are found in the sixth chapter of the Parental Code (1949). The best interest of the chi
Direct bandgap metal lead halide perovskites offer promising optoelectronic properties desirable in a wide range of applications including photodetection. However, the incomplete and poor understanding of the photophysical processes taking place in these materials, along with their poor stability, is the bottleneck for optimisation and further development of metal halide perovskite devices. In thi
Fire and grazing, a disaster or opportunity? Due to climate change, disturbances such as forest fires are expected to see an increase in frequency in the 21st century. Fires can increase species diversity since it can create habitats for early successional species. At least if it does not happen too often. Imagine living in a house that burns down every year, it would not be a very nice place to
