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pnas201311187 4375..4384 Region-specific restoration of striatal synaptic plasticity by dopamine grafts in experimental parkinsonism Daniella Rylandera,b, Vincenza Bagettab, Valentina Pendolinob, Elisa Ziannic, Shane Grealishd, Fabrizio Gardonic, Monica Di Lucac, Paolo Calabresib,e, M. Angela Cencia, and Barbara Picconib,1 aBasal Ganglia Pathophysiological Unit, Lund University, BMC F11, 22184 Lun

https://www.regenerative-neurobiology.lu.se/sites/regenerative-neurobiology.lu.se/files/publication_in_pnas.pdf - 2026-05-10

Background: Attention deficit hyperactivity disorder (ADHD) in children is associated with hyperactivity and impulsivity, attention problems, and difficulties with social interactions. Pharmacological treatment may alleviate the symptoms of ADHD but this rarely solves difficulties with social interactions. Children with ADHD may benefit from interventions designed to improve their social skills.We

Background: Free oxygen radicals have been implicated in the pathogenesis of bronchopulmonary dysplasia (BPD) in preterm infants. Superoxide dismutase (SOD) is a naturally occurring enzyme which provides a defense against such oxidant injury. Providing supplementary SOD has been tested in clinical trials to prevent BPD in preterm infants. Objectives: To determine the efficacy and safety of SOD in

Vilken betydelse har det förvetenskapliga för vetenskapen? Vilka betydelser kan det ha? Ska vi som forskare eftersträva största möjliga vetenskaplighet från början till slut? Annorlunda uttryckt: Ska vi metodiskt trycka bort våra förvetenskapliga impulser? Eller ska vi tvärtom välkomna dem? Att följa varje förvetenskaplig impuls, var vi än befinner oss i forskningsprocessen, skulle förmodligen få

Background: Middle Eastern immigrants represent a growing population in Sweden today. This group are at higher risk for type 2 diabetes than the native population, but are also shown to exhibit unique properties; despite an abundance in traditional cardiometabolic risk factors such as obesity, dearranged blood lipids and diminished physical acitivity, this group seem to exhibit lower blood pressur

Background: According to the “brain-reserve hypothesis” in Alzheimer’s disease (AD), patients with more years of education are expected to have higher cognitive status during adulthood. Hence, they might have a relatively larger burden of AD pathology and a more advanced level of the disease when dementia is clinically evident. Higher educated people would also be expected to perform better on sta

Importance: Patients who survive severe intracerebral hemorrhage (ICH) and intraventricular hemorrhage (IVH) typically have poor functional outcome in the short term and understanding of future recovery is limited. Objective: To describe 1-year recovery trajectories among ICH and IVH survivors with initial severe disability and assess the association of hospital events with long-term recovery. Des

BACKGROUND: During the last 5 years, there has been an increase in the use of unicompartmental knee arthroplasty (UKA) to treat knee osteoarthritis in Australia, and these account for almost 6% of annual knee replacement procedures. However, there is debate as to whether a fixed bearing or a mobile bearing design is best for decreasing revision for loosening and disease progression as well as impr

Background: The T-peak-to-T-end ($\mathrm{T}_{pe}$) interval has shown potential in predicting ventricular arrhythmic risk. It is an appealing index to be measured during ischemia since it is less influenced by ST-segment changes than the early part of the T wave. A time-warping-based index, derived from a spat

Background: Clinical egg allergy is a common food allergy. Current management relies upon strict allergen avoidance. Oral immunotherapy might be an optional treatment, through desensitization to egg allergen. Objectives: To determine the efficacy and safety of oral and sublingual immunotherapy in children and adults with immunoglobulin E (IgE)-mediated egg allergy as compared to a placebo treatmen

Syftet med studien är att undersöka det förbättrade upptaget av det radioaktiva spåret Technetium-99m-DTPA (99mTc-DTPA) i råtta Muskelvävnad i Fischer 344 råttor efter applicerade elektriska pulser med olika fältstyrka och pulslängd,Metoder: 99mTc-DTPA (totalt 150 MBq) administrerades intramuskulärt (i.m.) vid axeln som en bolus i flera fraktioner av 50 l vardera i intervaller på 1 minut. Bilder

UNLABELLED: Persistent CB1 cannabinoid receptor activity limits neurotransmitter release at various synapses throughout the brain. However, it is not fully understood how constitutively active CB1 receptors, tonic endocannabinoid signaling, and its regulation by multiple serine hydrolases contribute to the synapse-specific calibration of neurotransmitter release probability. To address this questi

STUDY QUESTION Does an intensive weight reduction programme prior to IVF increase live birth rates for infertile obese women? SUMMARY ANSWER An intensive weight reduction programme resulted in a large weight loss but did not substantially affect live birth rates in obese women scheduled for IVF. WHAT IS ALREADY KNOWN Among obese women, fertility and obstetric outcomes are influenced negatively wit

Older people with arrhythmias comprise a large group requiring complex care, posing many healthcare challenges. Rapid growth of the older population demands a better understanding of the needs of this patient group. The aim of this thesis was to investigate arrhythmia prevalence, incidence, survival, and experiences from the perspective of a geriatric population (aged 60+ years), and to examine th

Background: At birth, infants' lungs are fluid-filled. For newborns to have a successful transition, this fluid must be replaced by air to enable effective breathing. Some infants are judged to have inadequate breathing at birth and are resuscitated with positive pressure ventilation (PPV). Giving prolonged (sustained) inflations at the start of PPV may help clear lung fluid and establish gas volu

It is established that the glomerular filter sieves macromolecules based on their size, shape, and charge. Anionic proteins are thus retarded compared with their neutral or cationic counterparts. However, recent studies have indicated that charge effects are small, or even "anomalous," for polysaccharides. We therefore investigated the impact of charge on the glomerular permeability to polysacchar

Popular Abstract in Swedish Graviditetsdiabetes är diabetes som uppkommer eller först upptäcks under en graviditet. Mellan 1-14 % av alla gravida kvinnor runt om i världen drabbas av graviditetsdiabetes och i Sverige är det ungefär 2 %. I Sverige behandlas graviditetsdiabetes med kostråd och om detta inte räcker lägger man till insulinbehandling. Kända riskfaktorer för att utveckla graviditetsdiabGestational diabetes mellitus (GDM) occurs as a complication in 2% of all pregnancies in Sweden. Women with GDM have a substantial risk of developing type 2 diabetes later in life, but the risk of developing type 1 diabetes is also increased. GDM increases the risk for macrosomia and caesarean delivery. However, long term prognosis and eventual future risks for children born to mothers with a prev

Background Smokers have a substantially increased risk of postoperative complications. Preoperative smoking intervention may be effective in decreasing this incidence, and surgery may constitute a unique opportunity for smoking cessation interventions. Objectives The objectives of this review are to assess the effect of preoperative smoking intervention on smoking cessation at the time of surgery

Life oil earth was formed during billions of years, exposed to, and shaped by the original physical forces such as gravitation, cosmic irradiation, atmospheric electric fields and the terrestrial magnetism. The Schumann resonances at 7.4 Hz are all example of oscillations possibly important for life.(1)) The existing organisms are created to function in harmony with these forces. However, in the l

Popular Abstract in Swedish Hur lurar mördarbakterier våra celler? Neutrofiler och fagocytos räddar liv Utan vårt immunförsvar så skulle vi snabbt dö i infektioner från mikroorganismer. Det består ett komplicerat system av celler och molekyler som tillsammans kan klara av att stå emot attacker från bakterier, virus, svampar eller parasiter. Cellerna i immunförsvaret utgörs av vita blodkroppar ochNeutrophils are our most numerous and deadly white blood cells and without them we would succumb quickly to infections by pathogens. The main mechanism that the neutrophils employ for our protection is phagocytosis, where they eat and enclose their target inside a membrane-bound organelle, the phagosome. Neutrophil phagosomes are highly dynamic entities, and a large amount of antimicrobial substan