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Background: The apolipoprotein E (APOE) ε4 allele is associated with higher cholesterol levels, and an increased risk of developing Alzheimer’s disease (AD) and amyloid-related imaging abnormalities after initiation of amyloid-modifying therapies. A worse cognitive response to cholinesterase inhibitor (ChEI) treatment and longitudinal outcome in APOE ε4-carriers has been observed. Based on these c

Background: Current evidence supports the use of intravenous thrombolysis with alteplase in patients with wake-up stroke selected with MRI or perfusion imaging and is recommended in clinical guidelines. However, access to advanced imaging techniques is often scarce. We aimed to determine whether thrombolytic treatment with intravenous tenecteplase given within 4·5 h of awakening improves functiona

The doubly magic nucleus ¹⁰⁰Sn represents a crucial test for the nuclear shell model, which is a widely used model for a quantitative description of nuclei. Excited states in ¹⁰⁰Sn are experimentally not accessible with present day techniques, but it is possible to gain insight into its structure by studying the properties of excited states of neighboring nuclei. These nuclei

This study aims to investigate and disentangle the impact of land use and climate variability on the Baltic Sea coastal zone from a millennial perspective. To assess the environmental status of the coastal zone we make use of siliceous microfossils (mainly diatoms), stable nitrogen and carbon isotopes, organic carbon accumulation rates, and lithological changes analyzed in a sediment core collecte

Ultrasonic motors (USMs) have been extensively studied for three decades, due to their attractive features, such as high torque at low speed, simple structure, and precise positioning capability. However, since USMs are driven by the friction force between the rotor and the stator in most cases, they inherently possess the friction loss and the wear of contact materials, which cause their low effi

Importance: Long-term follow-up after transcatheter aortic valve replacement (TAVR) is of interest given that longitudinal data on mortality and durability of transcatheter heart valves are limited. The REPRISE III (Repositionable Percutaneous Replacement of Stenotic Aortic Valve Through Implantation of Lotus Valve System-Randomized Clinical Evaluation) randomized clinical trial compared the mecha

Background: Current systemic therapies for metastatic pancreatic ductal adenocarcinoma are associated with poor outcomes with a 5-year overall survival rate under 5%. We aimed to assess the safety and antitumour activity of mitazalimab, a human CD40 agonistic IgG1 antibody, with modified FOLFIRINOX (mFOLFIRINOX; fluorouracil, leucovorin, oxaliplatin, and irinotecan), in chemotherapy-naive patients

IMPORTANCE: Prostate-specific antigen (PSA) screening has potential to reduce prostate cancer mortality but frequently detects prostate cancer that is not clinically important.OBJECTIVE: To describe rates of low-grade (grade group 1) and high-grade (grade groups 2-5) prostate cancer identified among men invited to participate in a prostate cancer screening protocol consisting of a PSA test, a 4-ka

Popular Abstract in English The current interest in improving the nutritional benefits of food products and the need to recover undeveloped crops prompted us to study two plant roots: parsnip (Pastinaca sativa) and yacon (Smallanthus sonchifolius). Parsnip is a root native to Europe and Asia, and is often used for culinary purposes and to feed livestock. Parsnip was a popular vegetable in the MiddThe physicochemical properties of two root suspensions, parsnip (Pastinaca sativa) and yacon (Smallanthus sonchifolius), were studied and compared at different concentrations and after being subjected to processes such as homogenization and heating. The study and the evaluation of the physicochemical properties of these plant materials in the form of pastes might help to increase the interest in t

The aim of the project MASTER (MAnaging Speeds of Traffic on European Roads) was to produce information that can be cited in the preparation of national and EU decisions concerning speed management and speed control equipment standards. For this purpose, the project looked for answers to three key questions: 1)What are acceptable ranges of speeds? 2)What are the key factors influencing drivers’ ch

Popular Abstract in Swedish Avhandlingen handlar om hur fett (lipider) i kosten bryts ner och transporteras i blodet för att slutligen antingen användas som energi, byggstenar i cellväggarna eller lagras i fettväven. I den här avhandlingen kan man också läsa om hur man kan modifiera fetter med hjälp av speciella proteiner: enzymer för att förbättra näringsinnehållet och dess fysikaliska egenskaperAn important indicator of the metabolic capacity of humans is the ability to regulate plasma triacylglycerol levels and to clear triacylglycerol-rich lipoproteins (TRLs) from the circulation after a meal. This is crucial since most of the day is spent in the postprandial state. High concentrations and long circulation times of TRL remnants may be detrimental since these are considered to be highly

The impact of cytogenetic findings in AML was analyzed in the large population-based Swedish AML registry. Karyotypic patterns differed by age: t(8;21), inv(16) and t(11q23) were more common in younger patients, whereas loss of 5q, 7q and 17p, monosomal karyotype (MK) and complex karyotype (CK) were more common in older patients. Patients with ≥5 chromosome abnormalities had worse overall survival

Popular Abstract in Swedish Beräkningar från Cancerfonden visar på att ungefär var tredje person i Sverige kommer att få en cancerdiagnos under sin livstid. Cancerceller är celler som har utvecklat speciella förmågor som gör att de har börjat dela sig ohämmat. Denna ohämmade celldelning leder till bildandet av en tumör och när tumören har nått ett visst stadie i sin utveckling så börjar den spridaAs a cancer grows it will, at a certain stage of disease progression, start spreading in the body. For several types of cancer this spreading will first occur through the lymphatic system and the first place where metastatic cell will be encountered is the first lymph node that drains the area where the tumor is located. This lymph node is defined as the sentinel lymph node (SLN). By analyzing the

Chemical Loping Combustion (CLC) is a novel combustion technology in which the exhaust gas is inherently divided into oxygen depleted air in one stream and CO2 and water vapour in another. This is however under the ideal condition that the fuel conversion is complete, i.e. all the hydrocarbons in the fuel is transformed to heat, water vapour and CO2. The CO2 capture rate can under such ideal condi

Numerous Neoproterozoic mafic dykes, referred to as the Dashigou swarm, are identified in the central and southeastern parts of the North China craton (NCC). They are 305-010 degrees trending dykes, with widths of similar to 10-100 m and exposed lengths of several to >10 km. Precise U-Pb isotope dilution thermal ionization mass spectrometry (ID-TIMS) measurements on baddeleyite grains separated fr

https://www.saco.se/globalassets/lokala-akademikerforeningar/statlig/linkopings-universitet-liu/dokument/avtal/arbetstidsavtal99.pdf - 2026-05-08

ORIGINAL ARTICLE Efficient transduction of neurons using Ross River glycoprotein-pseudotyped lentiviral vectors J Jakobsson, T Tolstrup Nielsen, K Staflin, B Georgievska and C Lundberg Department of Experimental Medical Research, Section for Neuroscience, Wallenberg Neuroscience Center, Lund University, Lund, Sweden Lentiviral vectors are promising tools for CNS gene transfer since they efficientl

https://www.molecular-neurogenetics.lu.se/sites/molecular-neurogenetics.lu.se/files/3302701.pdf - 2026-05-08

Parkinson’s disease (PD) is the most com- mon cause of movement disorder and has a median age-of-onset of ~55 years. It presents with a classical triad of motor symptoms: akinesia, rigidity and tremor. Many patients also suffer from non-motor symptoms, including disturbances of autonomic func- tions and deterioration of cognition1. The aetiology and pathogenetic mechanisms that cause PD remain eni

https://www.wnc.lu.se/sites/wnc.lu.se/files/brundin_et_al_nature_rev_neurosci_2008.pdf - 2026-05-08

How it started 50 years ago Our pioneering experiments using fetal neural grafting in the brain and the path to the first clinical trial Compiled by me, Anders Björklund, in November-December 2024 Up until the 1990s, when digital cameras came in common use, microscopic pictures were captured as negative images on 35 mm roll film from which positive paper prints were made. My archive of negatives f

https://www.regenerative-neurobiology.lu.se/sites/regenerative-neurobiology.lu.se/files/2026-03/How%20it%20started%2050%20years%20ago.pdf - 2026-05-08