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Circulating Human Basophils and Dendritic Cell Subsets. Aspects of antigen recognition and presentation in type I allergic immune responses

Popular Abstract in Swedish En tredjedel av befolkningen i världens industrialiserade länder lider av allergi, t.ex. allergisk rinit (hösnuva). Trots detta vet man relativt lite om de cellulära och molekylära mekanismer som ligger till grund för det immunologiska svaret vid allergi. Genom att studera dessa mekanismer kan man hitta sätt att angripa dem, vilket förhoppningsvis kan leda till bättre lAllergic diseases currently affect a third of the population in the industrialized parts of the world. Despite this, the cellular and molecular mechanisms involved in the induction and activation of allergic diseases are not fully clarified. Dendritic cells (DCs) link the innate and adaptive immunity and play vital roles in protective immunity against pathogens, as well as in inducing tolerance t

Local CTLA4 blockade effectively restrains experimental pancreatic adenocarcinoma growth in vivo.

Antibody-mediated blockade of CTLA4 has been shown to be effective in treating a select group of patients with late-stage melanoma. The precise mechanism underlying the clinical activity of CTLA4 immunotherapy is poorly understood, although recent experimental findings indicate that antibody-mediated depletion of regulatory T cells (Tregs) in the tumor microenvironment plays a key role in efficaci

Studies of bacterial surface proteins interacting with the immune system

Popular Abstract in Swedish En av de viktigaste substanserna i vår kropp är proteiner, också kallade äggviteämnen. Proteiner har en mängd olika uppgifter i kroppen, de finns i våra celler där de har olika uppgifter såsom att fungera som enzymer, transportörer, signalsubstanser, eller som skyddsfaktorer. Proteiner ingår också som viktiga beståndsdelar i vävnaderna mellan cellerna och finns dessutomPathogenic bacteria express a wide array of surface proteins that interact with the environment. Many of these proteins are believed to be important for the virulence. This thesis deals with the binding of immunoglobulins (Ig) and complement regulating proteins to certain bacterial surface proteins. Protein L from Peptostreptococcus magnus binds to Igk-light chains while protein A from Staphylococ

Eosinophils in anti-neutrophil cytoplasmic antibody associated vasculitis

Background: Anti-neutrophil cytoplasmic antibodies associated vasculitides (AAV) are characterized by autoimmune small vessel inflammation. Eosinophils are multifunctional cells with both pro-inflammatory and immunoregulatory properties. Tissue activated eosinophils secrete cyto- and chemokines and form extracellular traps (EETs), they release free granules and produce reactive oxygen species. The

Multitask Convolutional Neural Network Emulators for Global Crop Models - Supervised Deep Learning in Large Hypercubes of Non-IID Data

The aim of this thesis is to establish whether a neural network (NN) can be used for emulation of simulated global crop production - retrieved from the computationally demanding dynamic global vegetation model (DGVM) Lund-Potsdam-Jena General Ecosystem Simulator (LPJ-GUESS). It has been devoted to elaboration with various types of neural network architectures: Branched NNs capable of processing in

T2 cytokine-driven alarmin and antiviral responses in asthma: insights into immune modulation and the role of IL-4Ra targeting

Introduction: Severe asthma is a heterogeneous condition characterized bydistinct phenotypes and endotypes based on clinical or biologicalcharacteristics. Interleukin (IL) 4 and IL-13 are central cytokines in the type 2(T2) immune response, crucial for T2 inflammation. Biologic therapiestargeting the IL-4/IL-13 pathway, such as anti-IL-4Rα monoclonal antibodies(mAbs), have shown improvements in luIntroduction: Severe asthma is a heterogeneous condition characterized by distinct phenotypes and endotypes based on clinical or biological characteristics. Interleukin (IL) 4 and IL-13 are central cytokines in the type 2 (T2) immune response, crucial for T2 inflammation. Biologic therapies targeting the IL-4/IL-13 pathway, such as anti-IL-4Rα monoclonal antibodies (mAbs), have shown improvements

Special-area-studies-schedule-spring-25

Special Area Studies, spring 2025 Special Area Studies ACCESSIBLE TO ALL EXCHANGE STUDENTS, SPRING 2025 SAS COURSES AT THE JOINT FACULTIES OF HUMANITIES AND THEOLOGY Information may be requested from: international@ht.lu.se | Webpage: www.ht.lu.se/en/international/ MONDAY A.M. SASH65 History of the Holocaust 20 January –10 March 10.15 –12.00 (Mon. and Thur.) Department of History LUX SASH66 One Wo

https://www.lunduniversity.lu.se/sites/www.lunduniversity.lu.se/files/2024-12/Special-area-studies-schedule-spring-25.pdf - 2026-05-23

LundaEkonomerna student union

THE STUDENT UNION FOR ALL STUDENTS AT LUSEM LundaEkonomerna are dedicated to optimize the student life for their members, and their main purpose is to continuously monitor the quality of education by representing the students’ opinions towards the school. However, there is way more to LundaEkonomerna than this fundamental function. Our student union stands on four pillars – education, career, soci

https://www.lusem.lu.se/study/student-web/lundaekonomerna-student-union - 2026-05-22

Microsoft Word - OtydligaMaal_V101_utankomm.doc

Microsoft Word - OtydligaMaal_V101_utankomm.doc LTHs 10:e Pedagogiska Inspirationskonferens, 6 december 2018 Sammanfattning—CEQ-resultaten för en del projektbase- rade kurser visar att studenterna upplever att kursens mål inte är tydliga (skalan ”Tydliga mål”, TM, i CEQ). Studenterna verkar således vara ganska osäkra på vad lärarna förväntar sig av dem. Detta är ett problem som kräver uppmärksamh

https://www.lth.se/fileadmin/lth/genombrottet/konferens2018/D5_Motte_etal.pdf - 2026-05-22

The challenges of recruiting never-smokers with chronic obstructive pulmonary disease from the large population-based Swedish CArdiopulmonary bioImage study (SCAPIS) cohort

Background: A substantial proportion of individuals with COPD have never smoked, and it is implied to be more common than previously anticipated but poorly studied. Aim: To describe the process of recruitment of never-smokers with COPD from a population-based cohort (n = 30 154). Methods: We recruited never-smokers with COPD, aged 50–75 years, from six University Hospitals, based on: 1) post bronc

Mdc cardiovascular endpoint report 2017

The Malmö Diet and Cancer Study The Malmö Diet and Cancer Study Department of Clinical Sciences Skåne University Hospital, Malmö Lund University Malmö Diet and Cancer Study incl. CV-cohort Cardiovascular Endpoints End of follow-up: 31 December 2016 Report: 4 April 2018 Anders Dahlin Bo Hedblad (coronary events and stroke) Gunnar Engström (heart failure) Olle Melander (atrial fibrillation and flutt

https://www.malmo-kohorter.lu.se/sites/malmo-kohorter.lu.se/files/mdc_cardiovascular_endpoint_report_2017.pdf - 2026-05-23

Transglycosylation catalyzed by β-mannanases : Molecular aspects relevant for enzymatic synthesis

Att ersätta ändliga resurser med förnybara alternativ är en av mänsklighetens största utmaningar i modern tid. Utsläpp av växthusgaser orsakade av mänsklig civilisation behöver minska, och nya forskningsbaserade lösningar är nödvändiga för att åstadkomma långsiktigt hållbar tillväxt. I denna omställning kan biomassa från växter spela en viktig roll. Växtbiomassa består mestadels av socker som sitt

Thsk 01 examen lowrez 2

A v: L ar s N or én sp el pe r io d : 8 –2 2 m a rs | sp el pl at s: B rY G G er it ea te r N te at er h ö G sk o la N i m a lm ö | ex a m eN sp r o d u k ti o N # 1 Regi: Dennis Sandin Scenografi och kostym: Karin Gille 2 3 På scen: Markus/Birgit | Ebba J. Dahlberg Sofia/Rakels mamma | Stina Eriksson Martin | Vincent Grahl Erika | Martina Hemmingsson Anders | Rasmus Johansson Maud | Arina Katchin

https://www.thm.lu.se/sites/thm.lu.se/files/thsk_01_examen_lowrez_2.pdf - 2026-05-23