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Streptococcus pyogenes secreted enzymes interacting with the human host

Streptococcus pyogenes is one of the most common bacteria infecting humans. One of the factors contributing to the disease-causing properties is the secreted streptococcal cysteine proteinase, SpeB, which degrades several host proteins in connective tissue and circulation. SpeB activity depends on the transformation from an inactive precursor, zymogen, into a mature proteinase. We show that

Efficacy of T-cell assays for the diagnosis of primary defects in cytotoxic lymphocyte exocytosis

Primary hemophagocytic lymphohistiocytosis (HLH) is a life-threatening disorder associated with autosomal recessive variants in genes required for perforin-mediated lymphocyte cytotoxicity. A rapid diagnosis is crucial for successful treatment. Although defective cytotoxic T lymphocyte (CTL) function causes pathogenesis, quantification of natural killer (NK)–cell exocytosis triggered by K562 targe

Potentialities of manganese ore and iron-carbon particles for pharmaceuticals and personal care products removal in electroactive constructed wetland

This study explores the use of manganese ore, iron-carbon particles (Fe-C), and gravel as anode fillers in electroactive constructed wetlands (ECWs) to treat wastewater containing pharmaceuticals and personal care products (PPCPs) including ciprofloxacin (CIP), ofloxacin (OFL), and naproxen (NPX), while also assessing bioelectricity production. Although the presence of PPCPs reduced pollutant remo

Development and validation of a novel Simoa assay for NPTX2 in Alzheimer's disease and Down syndrome

INTRODUCTION: Synaptic dysfunction and loss are pathological hallmarks of neurodegenerative diseases. Neuronal pentraxin 2 (NPTX2), a presynaptic protein involved in synaptic plasticity, has been linked to cognitive decline in Alzheimer's disease (AD) and other neurodegenerative disorders. METHODS: We developed and validated a novel single molecule array (Simoa) for NPTX2 in cerebrospinal fluid, w

Structural determination of Streptococcus pyogenes M1 protein interactions with human immunoglobulin G using integrative structural biology

Streptococcus pyogenes (Group A streptococcus; GAS) is an important human pathogen responsible for mild to severe, life-threatening infections. GAS expresses a wide range of virulence factors, including the M family proteins. The M proteins allow the bacteria to evade parts of the human immune defenses by triggering the formation of a dense coat of plasma proteins surrounding the bacteria, includi

Vårterminen 2024

Här hittar du som är student eller medarbetare hos oss information om valbara kurser, kalendarium för hela terminen. JanuaryWeek 3: 15-21 January15.1    Official start of spring semester15.1     MFAAR meeting 10.00-11.0015.1     Meeting with the exchange students 11.00-11.3015.1    ALL STUDENTS 12.00-13.00 Student forum with lunch WELCOME TO NEW SEMESTER 19.1    Application portal BFA and MFA prog

https://www.khm.lu.se/varterminen-2024 - 2026-05-09

Jama lugar 2023 oi 230100 1695046175.41487

SARS-CoV-2 Infection and Development of Islet Autoimmunity in Early Childhood Marija Lugar, MSc; Anne Eugster, PhD; Peter Achenbach, MD; Thekla von dem Berge, MD; Reinhard Berner, MD; Rachel E. J. Besser, MD; Kristina Casteels, MD; Helena Elding Larsson, MD; Gita Gemulla, MD; Olga Kordonouri, MD; Annett Lindner; Markus Lundgren, MD; Denise Müller, BSc; Mariusz Oltarzewski, PhD; Anne Rochtus, MD; M

https://www.gppad.lu.se/sites/gppad.lu.se/files/2024-01/jama_lugar_2023_oi_230100_1695046175.41487.pdf - 2026-05-11

Jama lugar 2023 oi 230100 1695046175.41487

SARS-CoV-2 Infection and Development of Islet Autoimmunity in Early Childhood SARS-CoV-2 Infection and Development of Islet Autoimmunity in Early Childhood Marija Lugar, MSc; Anne Eugster, PhD; Peter Achenbach, MD; Thekla von dem Berge, MD; Reinhard Berner, MD; Rachel E. J. Besser, MD; Kristina Casteels, MD; Helena Elding Larsson, MD; Gita Gemulla, MD; Olga Kordonouri, MD; Annett Lindner; Markus L

https://www.gppad.lu.se/sites/gppad.lu.se/files/2023-10/jama_lugar_2023_oi_230100_1695046175.41487.pdf - 2026-05-11

Anthropometric and reproductive factors and risk of esophageal and gastric cancer by subtype and subsite : Results from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Obesity has been associated with upper gastrointestinal cancers; however, there are limited prospective data on associations by subtype/subsite. Obesity can impact hormonal factors, which have been hypothesized to play a role in these cancers. We investigated anthropometric and reproductive factors in relation to esophageal and gastric cancer by subtype and subsite for 476,160 participants from th

Energy Storage & Conversion

Sustainable energy storage and conversion explores innovative methods to efficiently store and transform energy from various renewable sources. It focuses on technologies like advanced batteries, hydrogen production, fuel cells, and thermochemical systems as well as safety aspects of battery storage systems. Research aims to enhance energy density, reduce costs, and improve scalability, enabling r

https://www.energy.lth.se/research/energy-storage-conversion - 2026-05-09

Luvre-035enemarmflinventerarvariation

ORNIS SCANDINAVICA 9: 31-29. Copenhagen 1978. The effect of observer variability on bird census results obtained by a territory mapping technique Anders Enemar Zoological Institute, University of Gothenburg, Sweden Bengt Sjostrand Institute of Marine Research, Lysekil, Sweden Soren Svensson Department of Animal Ecology, University of Lund, Sweden Enemar, A., Sjostrand, B. and Svensson, S. 1978. Th

https://www.luvre.lu.se/sites/luvre.lu.se/files/luvre-035enemarmflinventerarvariation.pdf - 2026-05-11

Mvec12 schema

Schema Riskanalys inom natur, miljö och hälsa MVEC12 15 högskolepoäng, HT 2014 PRELIMINÄRT version 20140825 VECKA DATUM DAG TID TITEL Form Lärare Läs SAL HUS BLOCK V. 36 01-sep må 13.00-14 Upprop, Kursintroduktion S MH Receptorn Biologihuset INTRODUKTION KURS 02-sep ti 10-12 Risker med nanopartiklar F MHE+MOK Ängen Ekologihuset HÄLSA 03-sep on 9-12 Introduktion om biomarkörer och hälsostudier F CL

https://www.cec.lu.se/sv/sites/cec.lu.se.sv/files/mvec12_schema.pdf - 2026-05-11

Schema mven18 vt 20 version2rev

Prel.Schema MVEN018 - Klimatstrategiska metoder Vårterminen 2019 OBS Alla starttider med kvart utom tentamen! Kurstid: 23-mar – 7 juni Kurschef: Niklas Vareman Lärare: CW Christine Wamsler HT Henrik Tehler HH Henrik Hassel US Ullrika Sahlin DP Dmytro Perepolkin NV Niklas Vareman AO Adelina Osmani LS Linn Svegrup JJ Jonas Johansson JMP Jurate Miliute-Plepiene AP Andrius Plepys Salar: Mossen, Ekolog

https://www.cec.lu.se/sv/sites/cec.lu.se.sv/files/schema_mven18_vt_20_version2rev.docx - 2026-05-11

Monte Carlo simulations of a clay inspired model suspension: the role of rim charge

We present a theoretical investigation of a model clay dispersion in 1-1 salt solutions by varying the particle volume fraction and ionic strength as well as the charge distribution on the clay platelets. The platelets are modeled as discs with charged sites distributed on a hexagonal lattice. The edge sites can be positively charged while the remaining sites are negative giving rise to a strong c

Schema MVEC10 HT22 220620

Preliminärt schema 20220620 Kurs: MVEC10 Riskbedömning inom natur, miljö och hälsa, 15 hp Kursansvarig: Maria C. Hansson Lärare: se nedan Lokaler: Liganden (D202) i Biologihuset, Sölvegatan 35, Lund Litteratur: Ingen kursbok, litteratur läggs upp på Canvas Studieteknik: Läs om studieverkstaden Studenträttigheter: Läs om dina rättigheter och skyldigheter som student Pedagogiskt stöd: Läs om pedagog

https://www.cec.lu.se/sv/sites/cec.lu.se.sv/files/2022-07/Schema%20MVEC10%20HT22%20220620.pdf - 2026-05-10

High Affinity Antibodies to Plasmodium falciparum Merozoite Antigens Are Associated with Protection from Malaria

Background: Malaria kills almost 1 million people every year, but the mechanisms behind protective immunity against the disease are still largely unknown. Methodology/Principal Findings: In this study, surface plasmon resonance technology was used to evaluate the affinity (measured as kd) of naturally acquired antibodies to the Plasmodium falciparum antigens MSP2 and AMA1. Antibodies in serum samp

Proteolysis of purified IgGs by human and bacterial enzymes in vitro and the detection of specific proteolytic fragments of endogenous IgG in rheumatoid synovial fluid

A comparative in vitro survey of physiologically relevant human and microbial proteinases defined a number of enzymes that induced specific hinge domain cleavage in human IgG1. Several of these proteinases have been associated with tumor growth, inflammation, and infection. A majority of the identified proteinases converted IgG to F(ab')(2), and a consistent feature of their action was a transient