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Impact of α-synuclein pathology on transplanted hESC-derived dopaminergic neurons in a humanized α-synuclein rat model of PD Impact of α-synuclein pathology on transplanted hESC-derived dopaminergic neurons in a humanized α-synuclein rat model of PD Deirdre B. Hobana,b, Shelby Shrigleya,b, Bengt Mattssona, Ludivine S. Bregerc, Ulla Jarla, Tiago Cardosoa,b , Jenny Nelander Wahlestedta,b, Kelvin C

https://www.regenerative-neurobiology.lu.se/sites/regenerative-neurobiology.lu.se/files/publication_in_pnas_5.pdf - 2026-05-23

Provision of assistive technologies (AT) is strongly connected to applying a person-centred approach, with focus on exploring the person’s individual abilities, needs and desires, to enable provision of matching AT. In the process of provision, it is also important to assess and facilitate the person’s understanding of how to use the AT, to enhance optimal usage and enable AT integration in everyd

Due to the possibility of increased efficiency and reduced emissions, Homogeneous Charge Compression Ignition (HCCI) is a promising alternative to conventional internal combustion engines. Ignition timing in HCCI is highly sensitive to operating conditions and lacks direct actuation, making it a challenging subject for closed-loop control. This paper presents physics-based, control-oriented modeli

This paper describes preliminary results from the test-retest of the NAME 1.0. Four scales were tested: Mobility-related participation frequency; Mobility ease/difficulty; Mobility dependence; Extent of assistance in mobility. The test was conducted in the five Nordic countries. In all 147 mobility device users took part in the study, mean age 60 years (range 19 - 93). Each participant was intervi

Popular Abstract in Swedish Inom ramen för detta forskningsprojekt har det utvecklats två resultat. En operativ teknik – kallad ”Tool for Strategic Territorial Planning (TSTP)” – som hjälper stadsplanerare att visualisera och bättre informera beslutsfattare om vilka effekter olika åtgärder får på fattigdoms bekämpning, har utvecklats. Detta genom att med statistisk information som grund, framställFew planning practices in the South seem to be equipped with key concepts and technical, empirical and administrative capacities required to comprehend and visualize the phenomenon of poverty at inter- and intra-urban levels, which compromises their ability to inform decision-makers on the effects on poverty reduction of the land-based actions they design, implement and monitor. This challenge was

Popular Abstract in Swedish Bekämpningsmedel och algblomningar - finns det någon koppling? Inom det konventionella jordbruket används idag regelmässigt stora mängder bekämpnings-medel, bara i sverige spreds under år 2001 mer än 1700 ton kemiska bekämpnings-medel på åkrarna. Ett stort problem med användandet av dessa ämnen är risken att de sprids och förorenar den intilliggande naturen. De kan driIn this thesis I have investigated the effects of pesticide exposure on the ecosystem level using various types of experimental ecosystems, i.e. microcosms. The direct effect of exposure to cyperemthrin, a pyretroid insecticide, was a rapid decrease of crustancean zooplankton in enclosures in a lake. In the exposed enclosures the biomass of algae, heterotrophic nanoflagellates, ciliates and bacter

The transcription factor interferon regulatory factor-8 (IRF8) is highly expressed in myeloid progenitors, while most myeloid leukemias show low or absent expression. Loss of IRF8 in mice leads to a myeloproliferative disorder, indicating a tumor-suppressive role of IRF8. The Wilms tumor gene 1 (WT1) protein represses the IRF8-promoter. The zinc finger protein ZNF224 can act as a transcriptional c

OBJECTIVE: To investigate plasma levels of circulating cell-free mitochondrial DNA (ccf-mtDNA) in patients with social anxiety disorder (SAD) and healthy controls (HC).METHODS: In this study, 88 participants (46 patients with SAD and 42 HCs) were enrolled and both ccf-mtDNA and peripheral blood mononuclear cells (PBMC) mtDNA copy number (mtDNA-cn) were measured at up to three times per individual

Some first investigations have focused on the consequences of the COVID-19 pandemic for the general mental health after its outbreak in 2020. According to multiple self-reporting surveys, symptoms of stress, anxiety, and depression have risen worldwide. Even some studies based on health care records start to be published, providing more objective and statistically reliable results. Additionally, c

The performance of HVAC equipment, including chillers, is continuing to be pushed to theoretical limits, which impacts the necessity for advanced control logic to operate them efficiently and robustly. At the same time, their architectures are becoming more complex; many systems have multiple compressors, expansion devices, evaporators, circuits, or other elements that challenge control design and

Microsoft Word - Thesis Jeffrey Harti 2009.doc Local Economic and Social Benefits of Corporate and Community Owned Wind Projects in Europe, Japan and North America Jeffrey Jonathan Michael Harti Thesis Supervisor: Barry Ness LUCSUS, Lund University Lund University International Master’s Programme in Environmental Studies and Sustainability Science Lund University Centre for Sustainability Studies

https://www.lumes.lu.se/sites/lumes.lu.se/files/harti_jeffrey_1.pdf - 2026-05-23

Den biologiska mångfalden fortsätter att minska trots att det såväl nationellt som internationellt finns en målsättning om att förlusten av den biologiska mångfalden ska hejdas. Idag anses en av de största miljöpolitiska utmaningarna vara att stoppa utarmningen av biologisk mångfald. Skogen utgör livsmiljö för hälften av alla landlevande arter i Sverige och ett hållbart skogsbruk är således livsavBiodiversity is in decline despite international and national goals of preventing this development. Preserving biodiversity is one of today’s greatest environmental policy challenges. Currently, half of all land living species in Sweden live in the forest, therefore a sustainable forestry industry is vital to ensure biodiversity. In fact, half of all red-listed species live in the forest. One of t

Georg Pauli belonged to a group of artists known as the Opponents, due to their opposition of the way art education, exhibitions, and allocation of grants was managed by the The Royal Swedish Academy of Fine Arts (Kungliga Akademien för de fria konsterna). Their oppositional work resulted in the formation of the Arts Association (Konst¬närs¬förbundet) in 1886. In a series of books and articles, in

Frakturer är ett stort och dessutom ökande samhällsproblem. Genom att stärka skelettet och muskulaturen kan risken för frakturer minskas. Hög fysisk aktivitet är associerad med hög benmassa, gynnsam skelettstruktur, god muskelfunktion och låg risk att drabbas av frakturer. Fysisk aktivitet skulle därför kunna vara en möjlig strategi för att minska antalet frakturer i samhället. Tidigare forskning

: Current practice of sustainable design encompasses a range of green strategies. Modernpassive design concepts have learned to build upon climate responsive methodology that was found in andinspired from vernacular and traditional buildings. With the present energy crises in Egypt there is a currentfocus on the development of climate sensitive design building approaches. It will be the thrust of