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Tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiency in Dutch neonates

Four neonates with a positive phenylalanine screening test (Phe concentrations between 258 and 1250 μmol/L) were investigated further to differentiate between phenylalanine hydroxylase (PAH) deficiency and variant hyperphenylalaninaemia (HPA) forms. In patients 1 and 2 a tetrahydrobiopterin (BH 4) load caused a significant decrease of the plasma Phe levels. A combined phenylalanine/BH 4 loading te

Behaviour of male pine sawflies, Neodiprion sertifer , released downwind from pheromone sources

This study investigated the behaviour of male European pine sawflies, Neodiprion sertifer Geoffroy (Hym., Diprionidae), that were released and observed downwind from pheromone traps baited with 100 mu g of the sex pheromone, (2S,3S,7S)-3,7-dimethyl-2-pentadecyl acetate. Releases were done at three distances; either at 5 m from one trap, or at 50 or 200 m from five traps, placed in a line perpendic

TRPV1 and TRPA1 stimulation induces MUC5B secretion in the human nasal airway in vivo.

Aim: Nasal transient receptor potential vanilloid 1 (TRPV1) stimulation with capsaicin produces serous and mucinous secretion in the human nasal airway. The primary aim of this study was to examine topical effects of various TRP ion channel agonists on symptoms and secretion of specific mucins: mucin 5 subtype AC (MUC5AC) and B (MUC5B). Methods: Healthy individuals were subjected to nasal challeng

DNA of Helicobacter spp. and common gut bacteria in primary liver carcinoma.

BACKGROUND AND AIM: Gastric and enteric Helicobacter species have been associated with the pathogenesis of some extragastric diseases. METHODS: We retrospectively investigated the presence of DNA of Helicobacter species in samples of the cancer and the surrounding tumour-free liver tissues of patients with hepatocellular carcinoma (HCC, n=12) and cholangiocarcinoma (CC, n=13). The patients were fr

Respondent-driven sampling in a syringe exchange setting.

Aims: Respondent-driven sampling is a research technique, new to the Scandinavian setting, used in hard-to-reach populations, such as subjects at risk for HIV, including drug users. This study aimed to evaluate the use of respondent-driven sampling originating from syringe exchange clients, as a method to identify 'hidden' drug users without treatment or social service contact. Methods: Nine heroi

Equal contribution of increased intracranial pressure and subarachnoid blood to cerebral blood flow reduction and receptor upregulation after subarachnoid hemorrhage.

Object Cerebral ischemia remains the key cause of disability and death in the late phase after subarachnoid hemorrhage (SAH), and its pathogenesis is still poorly understood. The purpose of this study was to examine whether the change in intracranial pressure or the extravasated blood causes the late cerebral ischemia and the upregulation of receptors or the cerebral vasoconstriction observed foll

Characteristics of aerosol particles formed during grate combustion of moist forest residue

The characteristics of aerosol particles formed during combustion of moist forest residue were studied as a function of load in a I MW moving grate boiler and at almost full load in a similar larger 6 MW boiler. The coarse (1 mum < d(ae) < 10 mum) particle number and mass concentration increased by more than one order of magnitude and the fine particle mean diameter, total volume and mass decrease

Iatrogenic bile duct injury - a cost analysis.

Introduction. Iatrogenic bile duct lesions following cholecystectomy represent a feared complication occurring in up to 0.9%. The aim of the present study was to estimate the total cost associated with both minor and major bile duct injuries. Material and methods. Detailed information on 24 consecutive patients, out of which 14 were considered to have minor and 10 patients considered as having maj

Anorexia nervosa outcome: six-year controlled longitudinal study of 51 cases including a population cohort

OBJECTIVE: Controlled study of intermediate term outcome of representative cases with adolescent-onset anorexia nervosa. METHOD: A group of 51 cases with anorexia nervosa with a mean age of reported onset of 14.3 years (including a total population of cases from one birth cohort) were compared with a sex-, age-, and school-matched group of 51 comparison subjects on various measures of outcome at

Combined fracture and mortality risk evaluation for stratifying treatment in hip fracture patients : A feasibility study

Objectives: This study aims to test the feasibility of the Fracture and Mortality Risk Evaluation (FAME) Index. Patients and methods: Two academic centers in Lithuania and Turkey participated in this retrospective study conducted between November 2018 and July 2019. A total of 100 consecutive patients (22 males, 78 females; mean age 78.9 years; range, 45 to 100 years) with low energy proximal femu

Prognosis of Syncope With Head Injury : a Tertiary Center Perspective

Aim: Head injury is the most common trauma occurring in syncope. We aimed to assess whether syncope as cause of head-trauma affects short-and long-term prognosis. Methods: From a database retrospective analysis of 97,014 individuals attending Emergency Department (ED), we selected data of patients with traumatic head injury including age, gender, injury mechanism, brain imaging, multiple traumas,

An investigation on the potential of bio-based polymers for use in polymer gear transmissions

The potential for replacing the fossil-based Polyoxymethylene (POM) and Polyamide 66 (PA 66) in polymer gear applications with a bio-based Polyamide 6.10 (PA 6.10) was studied and is presented in the article. The use of bio-based plastics is increasing but mostly in undemanding applications like packaging. High-performance plastics are needed in polymer gear transmissions since their operational c

A 5-year follow-up study of suicide attempts

Seventy-five patients were admitted to the ward of the Lund Suicide Research Center following a suicide attempt. After 5 years, the patients were followed up by a personal semistructured interview covering sociodemographic, psychosocial and psychiatric areas. Ten patients (13%) had committed suicide during the follow-up period, the majority within 2 years. They tended to be older at the index atte

May measurement month 2019 : The global blood pressure screening campaign of the international society of hypertension

Elevated blood pressure remains the single biggest risk factor contributing to the global burden of disease and mortality. May Measurement Month is an annual global screening campaign aiming to improve awareness of blood pressure at the individual and population level. Adults (≥18 years) recruited through opportunistic sampling were screened at sites in 92 countries during May 2019. Ideally, 3 blo

Laser-Rayleigh Imaging of DME Sprays in an Optically Accessible DI Diesel Truck Engine

Laser-Rayleigh imaging has been employed to measure the relative fuel concentration in the gaseous jet region of DME sprays. The measurements were performed in an optically accessible diesel truck engine equipped with a common rail injection system. A one-hole nozzle was used to guarantee that the recorded pressure history was associated with the heat release in the imaged spray. To compensate for

Sampling frequency affects the processing of ActiGraph raw acceleration data to activity counts.

ActiGraph acceleration data are processed through several steps (including bandpass filtering to attenuate unwanted signal frequencies) to generate the activity counts commonly used in physical activity research. We performed three experiments to investigate the effect of sampling frequency on the generation of activity counts. Ideal acceleration signals were produced in the MATLAB software. There

Assessment of Body Composition in Subjects with Metabolic Syndrome Comparing Single-Frequency Bioelectrical Impedance Analysis and Bioelectrical Spectroscopy.

Abstract Background: The aim of this study was to investigate the agreement between body composition measurements made with two methods-single-frequency bioelectrical impedance analysis (SF-BIA) and bioelectrical impedance spectroscopy (BIS). Methods: The body composition measurements using SF-BIA and BIS were performed seven times during 6 months on 41 patients (13 men and 28 women) with metaboli

Polymorphisms of the HDL receptor gene associated with HDL cholesterol levels in diabetic kindred from three populations

Objective: We examined polymorphisms in the HDL receptor, SR-BI, for association with plasma HDL cholesterol levels. Methods: Study subjects, including 847 women and 725 men, were from families originally ascertained for type 2 diabetes from Finland, Sweden and Israel. Four common polymorphisms were examined in linear regression analysis: an exon 1 missense (EX1), exon 8 silent (EX8), intron 5 (IV

Voyage without constellation: evaluating the performance of three uncalibrated process-oriented models

Three process-oriented dynamic acidification models were applied to a long-term monitoring site without calibration to evaluate the influence of model structural differences on simulation. The models were simplified to share as many commonalities as possible so that the main structural differences could be investigated. The models differed in sub-models for cation exchange, organic acids and acid ani

Feasibility of a branched stent-graft in common iliac artery aneurysms.

Purpose: To evaluate the short-term feasibility, efficacy, and safety of a modular bifurcated stent-graft with an internal iliac artery (IIA) side branch for endovascular repair of aortoiliac aneurysms. Methods: Between 2002 and 2005, 10 male patients (median age 75 years, range 59–83) were treated with a bifurcated stent-graft that included a unilateral side branch for the IIA. The median diamet