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Nanowires for Cell Research

Popular Abstract in Swedish Sammanfattning Den här avhandlingen handlar om gränsskiktet mellan nanoteknologi och cellbiologi, om hur celler och nanostrukturer påverkar varandra, och om hur man kan använda nanopinnar för att studera celler. Å ena sidan vill man kunna mäta egenskaper hos cellerna, det vill säga låta cellerna påverka pinnarna, å andra sidan vill man kunna styra cellerna – låta pinnarThis study explores the interaction between living biological cells and semiconductor nanowires. Biological cells are highly complex and dynamic entities, every one of them with individual characteristics and a high degree of internal and external communication. They respond to and affect their external environment with a huge web of fine-tuned control systems. Traditional biochemical tools for

Energy Efficient Processes for the Production of Gaseous Biofuels - Reforming and Gas Upgrading

Popular Abstract in Swedish Arbetet som presenteras i denna avhandling handlar om att utveckla nya processer för att producera gasformiga biobränslen som är mer energieffektiva än de som används idag. Genom att göra processerna mer energieffektiva kan kostnaden för att producera biobränslen minskas. En lägre produktionskostnad för biobränslet gör det lättare att ersätta fossila bränslen med förnyeReplacing fossil fuels with biofuels is one way of reducing the emission of greenhouse gases into the atmosphere, thus decreasing our impact on the global climate. For this to be a viable option, several production routes are needed, as no single option can fully replace fossil fuels. One way of making biofuels more competitive with fossil fuels is by reducing the production cost. As most of the p

Odour signals for detection and control of indoor pyralid moths

Three pyralid moths, the Mediterranean flour moth (Ephestia kuehniella), the almond moth (Ephestia cautella) and the Indian meal moth (Plodia interpunctella), infest food products all over the world and cause severe problems in factories, shops and households. For health and environmentalreasons chemical control becomes more and more restricted. We here present some promising results offering effi

Denitrification as an adaptive trait in soil and groundwater bacteria

The focus of the thesis is on selection and adaptation processes in bacteria with emphasis on denitrifying bacteria in groundwater. Other nitrogen transformation processes such as dissimilatory nitrate reduction to ammonium (nitrate ammonification) and nitrification of forest soil bacteria are briefly discussed. Intensive fertilisation of agricultural soils in southern Sweden have been performed

Targeting population groups with heavier burden of hepatocellular carcinoma incidence : a nationwide descriptive epidemiological study in Sweden

Contemporary European studies examining associations between socioeconomic status and hepatocellular carcinoma (HCC) incidence are scarce. We aimed to target population groups with a heavier burden of HCC by assessing associations of individual-level sociodemographic variables and neighbourhood deprivation with all-stage and stage-specific HCC incidence rates (IR). Patient and population data stra

A Gradual Transition Toward Anaplasia in Wilms Tumor Through Tolerance to Genetic Damage

Patients with Wilms tumor (WT) in general have excellent survival, but the prognosis of patients belonging to the subgroup of WT with diffuse anaplasia (DA) is poor due to frequent resistance to chemotherapy. We hypothesized that DA WT cells might undergo changes, such as acquiring a persistent tolerance to DNA damage and copy number aberrations (CNAs), which could eventually lead to their resista

Clinical outcomes in combination versus mono antibiotic therapy in ICU admitted patients with a suspected infection - A substudy of the DIANA study

PurposeIn a retrospective cohort study of intensive care unit (ICU) admitted adult patients with suspected or confirmed infection, associations between combination versus mono empirical antibiotic therapy and clinical cure at day 7 as well as mortality at day 7 and 28, were investigated.Materials and methodsPatients from the DIANA study were grouped and analysed by combination versus mono antibiot

Contributions of injury deaths to the changes in sex gaps in life expectancy and life disparity in the Nordic countries in the 21st century

OBJECTIVE: The objective of this study was to provide novel comparative insights on the contributions of injury deaths to the changes in sex gaps in life expectancy (SGLE) and sex gaps in life disparity (SGLD) across Nordic countries.STUDY DESIGN: Retrospective demographic analysis of aggregated mortality data.METHODS: To compute life expectancy (LE)/life disparity (LD), annual data on age- and se

Determining the residual volume in peritoneal dialysis using low molecular weight markers

Background: Variation in residual volume between peritoneal dialysis dwells creates uncertainty in ultrafiltration determination, dialysis efficiency, and poses a risk of overfill if the residual volume is large. Measuring the dilution of a marker molecule during fluid fill offers a convenient approach, however, estimation accuracy depends on the choice of dilution marker. We here evaluate the fea

Dynamics of violence in the retail service encounter – emotional labour and frontline work in high crime areas

This paper presents a novel approach to understanding violence in service encounters through a sociological lens, focusing specifically on micro-interactional violence. Traditionally, research on violence has focused on structural aspects, linking it to the capitalist system or viewing it as symbolic violence (Gordon & Zainuddin, 2020; Varman, 2010). This study, however, shifts the focus to th

Primary care indicators for disease burden, monitoring and surveillance of COVID-19 in 31 European countries: Eurodata Study

Background: During the COVID-19 pandemic, the majority of patients received ambulatory treatment, highlighting the importance of primary health care (PHC). However, there is limited knowledge regarding PHC workload in Europe during this period. The utilization of COVID-19 PHC indicators could facilitate the efficient monitoring and coordination of the pandemic response. The objective of this study

Care-seeking patterns and timely access to care among survivors of sexual violence in North Kivu, the Democratic Republic of the Congo : a retrospective file-based study

Background: Sexual violence is widespread in war-torn North Kivu province in the Democratic Republic of the Congo (DRC). Timely access to care is crucial for the healing and wellbeing of survivors of sexual violence, but is problematic due to a variety of barriers. Through a better understanding of care-seeking behaviours and factors influencing timely access to care, programmes can be adapted to

coPERCIST : AI-assisted PET-CT response assessment

Purpose: The PET Response Criteria in Solid Tumours (PERCIST) 1.0 provides a standardized framework for evaluating treatment response using [18F]fluorodeoxyglucose ([18F]FDG) positron emission tomography – computed tomography (PET-CT), but its clinical use is hindered by manual complexity. This study presents coPERCIST, an artificial intelligence (AI)-assisted module integrated into the RECOMIA pl

A comparative study of migratory behaviour while crossing large geographical barriers in three long-distance migratory passerines

Migratory behaviour explains how individuals or populations perform their migration. In birds this can include nocturnal or diurnal flights, long or short flights as well as low or high flight altitudes and several other behaviours. These behaviours shift throughout the migratory journey and especially when crossing barriers (large geographical areas where birds might have difficulties to find res

Elevated psychiatric and substance use disorders in people with intellectual disabilities in a Swedish National Sample

Background. Adults with intellectual disability (ID) experience marked mental health inequities, yet population-wide estimates that capture both primary- and specialist-care diagnoses remain scarce. Methods. Using nationwide Swedish registries, including primary care, specialist, inpatient, prescription drug, criminal, and suspicion registers, we included all individuals born in Sweden between 195

Prevalence of musculoskeletal disorders and physiotherapy utilization in primary care - a registry-based study in Sweden

BACKGROUND: Previous research has identified a need for relevant evidence-based clinical guidelines in primary care physiotherapy. However, an essential first step is to identify the most prevalent diagnoses among patients seeking physiotherapy. Thus, this study aims to (I) identify the most prevalent musculoskeletal diagnoses and, (II) describe physiotherapy utilization and patient characteristic

Kustlinjeutveckling vid Ystad Sandskogs västra strand: Modellering i ShorelineS med fokus på kustparallell sedimenttransport och kusterosion

I följande examensarbete undersöks den morfologiska kustlinjeutvecklingen vid den västra stranden i Ystad Sandskog med fokus på kusterosion och längsgående sedimenttransport. Kuststräckan är historiskt och fortsatt erosionsutsatt och ligger i nära anslutning till bebyggelser, infrastruktur och naturreservatet Sandskogen. För att motverka kustens tillbakadragning har flera kustskyddsåtgärder implemThis master thesis investigates the morphological shoreline development at the western beach of Ystad Sandskog, with a focus on coastal erosion and longshore sediment transport. The coastline is affected by erosion and is located close to residential areas, infrastructure and the nature preserve Sandskogen. Several coastal protection measures have been implemented to prevent ongoing shoreline retr

Elevated liver enzymes in Turner syndrome during a 5-year follow-up study

Objectives To study the prevalence and incidence of elevated liver enzymes and their relationship with body weight, metabolic factors and other diseases in Turner syndrome (TS). Design Five-year follow-up. Patients Women with TS (n = 218, mean age 33 +/- 13, range 16-71 years) from outpatient clinics at university hospitals in Sweden. Measurements Fasting blood samples for aspartate (AST) and alan

Cytogenetic findings in 33 osteosarcomas

Thirty-three osteosarcomas (OS) were analyzed cytogenetically. Clonal chromosome changes were detected in 17 cases. Six tumors had chromosome numbers in the diploid range, 6 in the triploid range, 1 in the tetraploid range and 1 in the pentaploid range, while 3 tumors had multiple clones with different ploidy levels. Including the present 17 tumors, a total of 27 OS with clonal aberrations have be

Phase I/II clinical and pharmacokinetic study evaluating a fully human monoclonal antibody against EGFr (HuMax-EGFr) in patients with advanced squamous cell carcinoma of the head and neck

Purpose: To assess safety, tolerability, pharmacokinetics and clinical activity of HuMax-EGFr in patients with SCCHN. Patients and methods: Twenty-eight patients with SCCHN were enrolled. The study comprised a single-dose escalation part for assessment of safety issues followed by a repeat dose extension including 4 weekly infusions at the same doses. Efficacy and metabolic response were evaluated