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Background: Treatment of newly diagnosed acute myeloid leukaemia (AML) is based on combination chemotherapy with cytarabine (ara-C) and anthracyclines. Five-year overall survival is below 30%, which has partly been attributed to cytarabine resistance. Preclinical data suggest that the addition of hydroxyurea potentiates cytarabine efficacy by increasing ara-C triphosphate (ara-CTP) levels through

BACKGROUND: Patients with oesophageal and gastric cancer have a low likelihood of being cured and suffer from a broad spectrum of symptoms and problems that negatively affect their quality-of-life (QOL). Although the majority (67-75%) of patients at the time of diagnosis suffer from an incurable disease, research has primarily focused on the pre- and postoperative phase among patients treated with

The Swedish regions struggle with resource utilization issues that threaten the ability to provide timely and efficient healthcare to the citizens. This study aims to investigate and map the current production, planning, and scheduling processes within the Swedish healthcare, as well as develop a digital solution. This is done through a user-centered design process, with the goal of designing a d

En nyckel för att uppfylla klimatförändringsmålen är att producera mer mat från havet. Detta kan vara ett viktigt bidrag till livsmedelssystemet för jordbruket eftersom åkermarken är begränsad. Med en växande befolkning som behöver mat finns det bara inte tillräckligt med åkermark. Andra fördelar med mat från havet är att ingen bevattning eller befruktning behövs, och dessutom kan våra eutrofieradOne key to meet the climate change goals is to produce more food from the sea. This can be an important contribution to the agricultural food system. Since the arable land is limited and with a growing population that need to be fed the available arable land is simply not enough. Other advantages of food from the sea is that no irrigation or fertilization is needed, and in addition our eutrophied

Idén till det här examensarbetet föddes när vi tillsammans tillbringade en termin i London för snart tre år sedan. Vi bodde nära Hackney City Farm, en stadsbondgård i östra London. Ett stenkast från bullrande vägar och röda dubbeldäckare fanns får, kor, getter, åsnor, höns och grisar mitt i stan. Vi blev berörda och fascinerade av närheten mellan djur och människa i en urban miljö. I vårt examensInitially the idea for this thesis was born when we spent a semester together in London about three years ago. We lived close to Hackney City Farm, in the heart of eastern London. Within a stone’s throw from noisy roads and red double-deckers there were sheep, cows, goats, hens and pigs right in the middle of the city. We were fascinated and inspired by the closeness of animals and humans in a ver

Akustisk infångning kan bli ett värdefullt verktyg i medicinsk forskning Från ett enda blod- eller urinprov kan läkare få massvis med information om en patient - information som ger ledtrådar om allt från det allmänna hälsotillståndet till eventuell förekomst av infektioner eller inflammationer, eller huruvida patienten lider av en viss sjukdom. Detta beror på att provet innehåller massor av så kaMicrofluidic systems allow for fast and precise manipulation of small volume samples in a highly controlled environment. In such a system, acoustic trapping is a powerful tool, enabling non-contact isolation of cells and microvesicles from complex media. In this technique, an ultrasonic standing wave is introduced in the microchannel. The standing wave exerts size-dependent acoustic forces on part

Image quality is in essence based on subjective experience, and the involvement of human subjects is therefore necessary in one way or the other in order to make reliable assessments of it. This topic is of interest for Axis Communications AB -- the market leader in surveillance cameras. In this thesis, the softcopy quality ruler method described in ISO 20462 is evaluated through a study of one s

Biotechnology company Medetect AB has developed a technology for staining of multiple cell types in the same tissue sample enabling positioning of cells as well as giving a way to distinguish between cell types. With new methods of visualising human tissue at a cellular level, comes a need to analyse this data. In this thesis, we therefore investigate some new methods, spectral non-parametric as w

Climate change is one of the most significant challenges that building sector is confronting. For example, Climate change and associated extreme events are posing a significant challenge for the building sector. Buildings should be prepared to withstand the climate changes and extreme weather that will happen in the future. Designing buildings based solely on past or average weather conditions, wh

The Swedish labour movement archives are an early example of community archives. Despite this, they have never been examined as such before. This study aims to examine how the labour movement archives functions as community archives, and how that function has changed over time. Since the first labour movement archive opened in Stockholm in 1903, and the subsequent archives opened in smaller Swedis

Det är väl känt att kolmonoxid (CO) är en giftig och hälsofarlig gas som är luktlös, färglös och smaklös vilket gör den svår att detektera utan analytisk utrustning. Men under senaste åren så har forskning bevisat att i små doser så kan kolmonoxid användas som en terapeutisk substans för att lindra malaria, cancer, lung-, hjärt- och kärlsjukdomar men även reducera mängden inflammatoriska substanseIt is well known that Carbon monoxide is a toxic and hazardous gas, but during recent years it has been proven that using a controlled concentration, carbon monoxide can in fact be used as a therapeutic agent, and can contribute to decrease malaria, treat cardiovascular and lung diseases and potentially even treat cancer, among other things. The main problem in using carbon monoxide directly is th

The emerging market for meat substitutes has largely been filled with different types of soy products. Although soy usually has a lower environmental impact than meat, soy is not entirely unproblematic. Deforestation and global transportations are two negative effects of the increasing production of soybeans. One of these meat substitutes is tempeh: an Indonesian mold-fermented food usually made o

Kubernetes is a container orchestration platform growing ever more popular, and as the software industry shifts into the container cloud, security will become paramount. The Common Vulnerabilities and Exposures (CVEs) systems cata- log and provide references to known vulnerabilities. The goal of this thesis is to systematically evaluate the security situation of Kubernetes through common mitigatio

Populärvetenskaplig sammanfattning Bakterieflora och Antibiotisk Resistens i Gouldsamadinen Gouldsamadinen (Erythrura gouldiae) är en färggrann fink som lever i norra Australien. Arten har minskat i antal under de senaste decennierna och idag anses den vara utrotningshotad. I ett försök att stärka den vilda populationen har man genomfört återintroduktioner med individer från voljärer till artensAbstract The release of captive bred birds may be an important conservation tool for endangered species of birds. In Australia attempts have been made to re-introduce Gouldian finches in the wild and the same action is considered for other endangered Australian finches. This might pose a risk as a broad range of infectious diseases have been described in captive Australian finches yet little is k

Whereas the link between impaired male fertility and risk of testicular and prostate cancer is well established, studies investigating non-reproductive cancer risk among men with impaired reproductive function are scarce and show conflicting results. The aim of the study was to compare the risk of developing non-reproductive cancers in men achieving paternity through assisted reproduction as compa

Importance Long-term follow-up studies regarding the safety of risk-reducing mastectomy (RRM) in terms of cancer risk and surgical complications among women with germline pathogenic variants (gPVs) in BRCA1 or BRCA2 (BRCA1/2) are scarce. Objective To analyze cancer risk and surgical complications after RRM. Design, Setting, and Participants This nationwide cohort study investigated 1208 Swedish wo

Thesis Purpose: With the increasing popularity of social networks like YouTube, and the increasing accessibility of consumers to devices able to make and edit videos, video reviews are facing a remarkable growth. Hitherto, the research in eWOM has paid more attention to written reviews, leaving a notable gap of research in video eWOM. The purpose of this study was to improve the knowledge about vi

As the importance of sustainability increases more weight is laid upon using both greener building materials and efficient transportation systems. As more and more buildings are being built with wood and other light weight materials, and ever more slender constructions, the need to understand the impact of vibrations in these types of structures increases. Furthermore the increasing urban density

Previous treatment studies have suggested an antidepressant effect of adjunctive probiotics, but more high-quality randomized controlled trials (RCTs) are needed before clinical implementation. The mechanisms underlying putative antidepressant effects of probiotics are not understood, but one possibility is that they are mediated via short-chain fatty acids (SCFAs) − neuroactive bacterial metaboli

Insikt och Handling 11 INSIKT OCH HANDLING Utgiven av Hans Larsson Samfundet Volym 11 CWK GLEERUP REDAKTÖR: URBAN FORELL ISSN: 0436-8096 ISBN: 91-40-03711-8 TRYCKNING: AB SKÅNSKA CENTRALTRYCKERIET, LUND 1974 TRYCKT MED BIDRAG FRÅN ANDERS KARITZ’S STIFTELSE, UPPSALA, LÄNGMANSKA KULTURFONDEN OCH STATENS HUMANISTISKA FORSKNINGSRÅD. PDF: TABULA, MÄRSTA 2020 ISBN: 978-91-88702-21-0 VERSION 1.0 — 2020-0

https://www.fil.lu.se/fileadmin/user_upload/fil/dokument/hanslarsson/Insikt_och_handling_vol_11.pdf - 2026-05-04