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Purpose: To assess baseline factors that may predict fast tibiofemoral cartilage loss over a 30-month period. Materials and Methods: The Multicenter Osteoarthritis (MOST) study is a longitudinal study of individuals who have or who are at high risk for knee osteoarthritis. The HIPAA-compliant protocol was approved by the institutional review boards of all participating centers, and written informe

Background: Activating KRAS mutations are common in ovarian carcinomas of low histological grade, less advanced clinical stage and mucinous histological subtype, and form part of the distinct molecular alterations associated with type I tumors in the dualistic model of ovarian carcinogenesis. Here, we investigated the occurrence, clinicopathological correlates and prognostic significance of specif

Two compounds, [Cu5I5](SNC5H4)2 [i] and [Cu3I3](SNC5H4)2 [ii], were synthesized under hydrothermal conditions and the crystal structures were solved. Both compounds crystallized in space group 141/a. The iodide and the sulphur from mercaptopyridine are connected to copper atom, giving the copper atoms tetrahedral coordination geometry. The pyridine end of the organic moiety is non-bonding and fill

Objectives To determine the accuracy of established ultrasound dating formulae when used at 12-14 weeks of gestation. Methods One-hundred and sixty-seven singleton pregnancies conceived after in-vitro fertilization (IVF) underwent a dating scan at 12-14 weeks of gestation. Gestational age at the dating scan was calculated by adding 14 days to the number of days between the date of oocyte retrieva

Amorphous Silica (ASi) is present in considerable amounts in most soils and serves as a (micro-)nutrient for many plants. However, our understanding of the response of this important nutrient pool to human or natural disturbances is still very limited. One of the reasons for this is the long time scales involved. This explorative study focuses on the effect of a historical agricultural system, cal

Public perception and anxiety of familial cancer have increased demands for clinical counseling, which may be well equipped for gene testing but less prepared for counseling of the large domain of familial cancer with unknown genetic background. The aim of the present study was to highlight the full scope of familial cancer and the variable levels of risk that need to be considered. Data on the 25

Background and Purpose - Aortic valve stenosis may lead to atrial and ventricular remodeling, predisposes to atrial fibrillation, and may also be an independent risk factor of ischemic stroke. However, information on stroke rates among persons with aortic valve stenosis are sparse. We aimed to determine the incidence rates and relative risks of ischemic stroke in individuals with diagnosed aortic

The aim of this study was to evaluate the degree of joint fusion and bone formation in dogs undergoing atlantoaxial arthrodesis after removal of articular cartilage associated or not to implant homogenous or autogenous cancellous bone. Twelve dogs, weighing between 8 and 12kg were randomly divided into three groups. Group I (GI) performed only the removal of joint cartilage and joint immobilizatio

Aim: The aim of this degree project is to carry out the corporate wide analysis and investigation to identify the existing and upcoming sustainable practices in Thule AB, general awareness and perception on sustainability among employees and to calculate carbon footprint of a bike rack, a Thule product produced at Seymour plant, USA. Approach: We embarked on this project by dividing it into two di

This Master’s thesis in library and information science deals with the development of Länkskafferiet, a SBIG created in 1994 by NetLab of the University Library of Lund. Länkskafferiet maintains a selection of quality controlled Internet links for the use of Swedish school children. We have had access to archives and files from the start of Länkskafferiet in 1994 to 2005 and have also interviewed

Purpose: To investigate the inflammatory response of current and future potential vitreous substitutes in an experimental in vivo vitrectomy model. Methods: Twenty-five gauge pars plana vitrectomy was performed in the right eye of 60 pigmented rabbits, with subsequent injection of 0.5–1.0 ml of Healaflow® (cross-linked hyaluronic acid, n = 12), Bio-Alcamid® (polyalkylimide, n = 8), silicone oil (n

This thesis contains two studies focusing on motivation in learning and teaching French as a foreign language in Sweden. In the first study, the effect of three specifically designed pedagogical activities on learners’ Ideal French Self (IFrS) and Intended Effort (IE) was examined in a group of 15-year-old Swedish pupils. No significant difference could be found between the two intervention classe

This study aimed to compare different image-based methods for bone marrow dosimetry and study the dose–response relationship during treatment with 177Lu-DOTATATE in patients with and without skeletal metastases. Methods: This study included 46 patients with advanced neuroendocrine tumors treated with at least 2 fractions of 177Lu-DOTATATE at Sahlgrenska University Hospital. High- and low-uptake co

In many natural ecosystems, predation is well recognized as a strong evolutionary force, and predator-mediated selection has been demonstrated to induce changes in prey morphology, life history and behaviour. In my thesis, I have focused on behavioural responses in aquatic prey under the risk of predation. I have used two different species of prey, the guppy (Poecilia reticulata) from high and low

Popular Abstract in Swedish POPULÄRVETENSKAPLIG SAMMANFATTNING IMMUNFÖRSVARET OCH KOMPLEMENTSYSTEMET Till skydd mot infektioner har människan sitt immunförsvar. Här ingår till exempel vita blodkroppar och en mängd olika proteiner. En viktig grupp av proteiner kallas för komplementsystemet, vilket består av ca 30 proteiner som kan angripa bakterier och andra oönskade partiklar och delta i för-störThe ability of many pathogenic microorganisms to cause infection is dependent on their ability to evade attack by the complement system of the host. One mechanism by which microorganisms may avoid complement attack is to bind complement inhibitory molecules present in the host. This thesis describes studies of the complement inhibitor C4BP and of inter-actions between C4BP and the human pathogen

Ultraviolet radiation (UV) has been present longer than any biological life, and during the development of life the radiation intensities were initially high. Eventually a vital ozone layer developed, but despite that this layer screens out most of the high energy wavelengths, some still enter the biosphere and is potentially harmful to life on earth. This thesis investigates the effects of combin

Importance: Repeat expansion of CGG in LRP12 has been identified as the causative variation of oculopharyngodistal myopathy (OPDM). However, to our knowledge, the clinicopathologic features of OPDM with CGG repeat expansion in LRP12 (hereafter referred to as OPDM_LRP12) remain unknown. Objective: To identify and characterize the clinicopathologic features of patients with OPDM_LRP12. Design, Setti

IMPORTANCE: Over the past decades, many global regions have experienced a steady increase in the incidence of cutaneous melanoma. However, more recently, a downward trend has been observed in the younger age groups in Australia and the US. Yet, in Europe, none of the countries have reported any significant decline in melanoma incidence for any age group.OBJECTIVE: To assess melanoma incidence and

Objective: To investigate the feasibility of active heart sparing (AHS) planning in patients with locally advanced and centrally located NSCLC receiving standard definitive radiotherapy (RT), while maintaining or improving appropriate lung, esophagus, and spinal cord constraints and planning target volume (PTV) coverage intent. Methods and materials: A total of 27 patients with stage IIIA/B NSCLC

The development of neuromorphic computing requires devices that can use low power consumption and highly parallel architecture to process and store information, similar to the biological nervous systems. Molecular photoswitches, especially Donor–Acceptor Stenhouse Adducts (DASAs), offer a promising platform for such applications, because they undergo reversible, light-driven structural changes and