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THOC5 : A novel gene involved in HDL-cholesterol metabolism

Although numerous genes are known to regulate serum lipid traits, identified variants explain only a small proportion of the expected heritability. We intended to identify further genetic variants associated with lipid phenotypes in a self-contained population of Sorbs in Germany. We performed a genome-wide association study (GWAS) on LDL-cholesterol, HDL-cholesterol (HDL-C), and triglyceride (TG)

Marine biomass for a circular blue-green bioeconomy? A life cycle perspective on closing nitrogen and phosphorus land-marine loops

A blue-green bioeconomy revolution is underway in Europe, with particular attention being paid to the development of new or underutilized marine biomass resources. The wild harvest and mariculture of low-trophic non-fed species of marine biomass may be contributing to circular economies, the mitigation of environmental problems such as eutrophication and climate change through the uptake of nutrie

Tenure track policies, procedures and career outcomes in a case study university in Ireland - a gendered critique

This chapter is a gendered critique of the tenure track (TT) model in Trinity College Dublin (TCD), the oldest and most prestigious university in Ireland, with a record of fast-paced change in gender representation since 2012. The methodology includes a documentary analysis augmented with qualitative data from TT appointees. All of those interviewed who had completed the TT process obtained tenure

Utility of serum and urine leucine-rich alpha-2 glycoprotein 1 (LRG1) as predictors of appendicitis and complicated appendicitis in children

PurposeLeucine rich alpha-2 glycoprotein 1 (LRG1) has emerged as a promising biomarker for appendicitis, especially in pediatric patients. However, the currently available data are sparse, and the biomarker must be validated in more settings and compared to standard inflammatory markers. We aimed to evaluate the diagnostic and discriminative utility of serum and urine LRG1 in children with other c

Identification of Poly(ADP-Ribose) Polymerase Macrodomain Inhibitors Using an AlphaScreen Protocol

Macrodomains recognize intracellular adenosine diphosphate (ADP)-ribosylation resulting in either removal of the modification or a protein interaction event. Research into compounds that modulate macrodomain functions could make important contributions. We investigated the interactions of all seven individual macrodomains of the human poly(ADP-ribose) polymerase (PARP) family members PARP9, PARP14

Preschool class pupils’ enhanced subitizing abilities by learning study interventions

Purpose: This study explores variation theory-based interventions’ contribution to enhancing preschoolers’ subitizing abilities during iterative lessons. Results are presented according to low, middle and high achievers, focused on those with prominent challenges. Design/methodology/approach: In total 68 Swedish preschoolers participated. They were randomly assigned to one of the intervention/cont

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Hydrothermal pretreatment was applied to wood sawdust, Trakya lignite and wood sawdust-Trakya lignite mixture (50%, wt) individually. Changes in fuel properties and thermochemical conversion characteristics of each were observed. In addition, the synergistic effect of biomass on coal with hydrothermal pretreatment of the mixture was investigated. After hydrothermal pretreatment, where the opti

A Cross-Sectional Study Demonstrating a High Prevalence of Skin Rash to Diabetes Medical Devices : An Underestimated Problem

Background: Adverse skin reactions to continuous glucose monitors (CGMs) and devices for continuous subcutaneous insulin infusions (CSIIs) (“diabetes medical devices” (MDs)) are well known. However, epidemiological studies on prevalence and skin rash details are lacking. The objective of this study was to describe the prevalence and details of skin rash to diabetes MDs in adults with type 1 diabet

Enligt vems regler? - Om anståndet med kupongskattens beräknings- och bevisningsreglers förenlighet med EU-rätten

Högsta förvaltningsdomstolen beslutade i mars 2025 att begära ett för-handsavgörande i ett mål gällande återbetalning med kupongskatt. Det ut-ländska företaget i målet menade att de inte var skyldiga att räkna ut sitt resultat enligt svenska regler, medan Skatteverket menade att det annars inte var möjligt att avgöra om det utländska företaget hade rätt till återbe-talning. Syftet med uppsatsen ärIn March of 2025, the Swedish Supreme Administrative Court decided to request a preliminary ruling in a case regarding repayment of Swedish withholding tax on dividends. The non-resident company claimed that they were not obligated to calculate their results according to Swedish rules, whereas the Swedish tax authority claimed that not doing so would make it impossible to determine whether the non

Considerations on dose constraints in interventional cardiology – first approach to establishing dose constraints

Various aspects related to establishing dose constraints (DCs) in interventional cardiology (IC) based on their features as defined in the recommendations of Publication 103 by the ICRP and the Basic Safety Standard Directive are presented. Preliminary DC values are proposed for the personal dose equivalent at 10 mm and 3 mm depth (Hp(10) and Hp(3) respectively). The methodology was based on the a

Evaluation of the dynamic patterns of sFlt−1, PlGF and their ratio in maternal plasma from diagnosis to postpartum as a new tool for preeclampsia management

Objective: To investigate the dynamic changes of soluble fms-like tyrosine kinase−1 (sFlt−1), placental growth factor (PlGF) and their ratio in maternal plasma, from preeclampsia diagnosis to postpartum, evaluating its clinical utility. Methods: Single-center prospective longitudinal cohort study with repeated sample collection in women with established preeclampsia (PE). Seventy-five (n = 75) wom

A study of the impact of nationalism on the portrayal of Jews in Swedish elementary school textbooks during the period 1900 to 1972

This investigation analysis the depiction of jews, in swedish textbooks in primary schools, during the period 1900 to 1972, in order to determine if the depictions are antisemitic. The study uses a qualitative text analysis to analyse the source material and, based upon Helen Feins definition of antisemitism, the study determines if descriptions of jews are antisemitic. The study reveals that de

Patch test results to extracts of synthetic garments in textile dye positive patients

Background: Disperse dyes (DDs) are the most prevalent causes of textile-related allergic contact dermatitis and are used for colouring synthetic textile materials based on fibres such as polyester, acrylic, acetate and polyamide. Eight DDs are included in a textile dye mix (TDM) 6.6% petrolatum (pet.) in the European baseline patch test series. Objectives: The aim of this study was to patch test

Gambierdiscus and Fukuyoa as potential indicators of ciguatera Risk in the Balearic Islands

Gambierdiscus and Fukuyoa are genera of toxic dinoflagellates which were mainly considered as endemic to marine intertropical areas, and that are well known as producers of ciguatoxins (CTXs) and maitotoxins (MTXs). Ciguatera poisoning (CP) is a human poisoning occurring after the consumption of fish or more rarely, shellfish containing CTXs. The presence of these microalgae in a coastal area is a

Terahertz Spectroscopic Analysis of Lactose in Infant Formula : Implications for Detection and Quantification

Lactose plays a significant role in daily lives as a constituent of various food and pharmaceutical products. Yet, lactose intolerance conditions demand low-lactose and lactose-free products in the market. These increasing nutritional claims and labels on food products entail simple and reliable methods of analysis that can be used for meeting quality standards, nutritional claims and legal requir

Dataset of dust mass accumulation rates for the loess-palaeosol sequences from the Carpathian Basin

In this article, a dataset of age-depth modelling data, sedimentation rates and dust mass accumulation rates (MAR) from four loess-palaeosol sequences from the Carpathian Basin is presented. The dataset is related to the article “Detailed luminescence dating of dust mass accumulation rates over the last two glacial-interglacial cycles from the Irig loess-palaeosol sequence, Carpathian Basin”, publ

Conformational control of antimicrobial peptide amphiphilicity : consequences for boosting membrane interactions and antimicrobial effects of photocatalytic TiO2 nanoparticles

This study reports on the effects of conformationally controlled amphiphilicity of antimicrobial peptides (AMPs) on their ability to coat TiO2 nanoparticles (NPs) and boost the photocatalytic antimicrobial effects of such NPs. For this, TiO2 NPs were combined with AMP EFK17 (EFKRIVQRIKDFLRNLV), displaying a disordered conformation in aqueous solution but helix formation on interaction with bacteri

Clarifying the relationship between physical injuries and risk for suicide attempt in a Swedish national sample

Introduction: The Interpersonal-Psychological Theory of Suicide proposes that capability for suicide is acquired through exposure to painful and provocative events (PPEs). Although there is robust evidence for a positive association between aggregate measures of PPEs and risk for suicidal behavior, little is known about the contributions of physical injuries. The present study investigated the rel

Expected features of the course leader in the rehabilitation healthcare professionals’ higher education : A qualitative study on students’ perspectives

Course leaders in rehabilitation healthcare professionals’ higher education face challenges stemming from multi-disciplinarity and the co-existence of different stakeholders. So far, the literature mainly attributed to course leaders’ managerial tasks, neglecting other fundamental transversal skills. Students represent an essential source of information for understanding the expected characteristi