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Antigen-binding sites dominate the surface properties of antibodies

We have found a remarkable relationship between the specificity of antibodies and their chromatographic behavious upon liquid-liquid partition chromatography (LLPC). Well characterized human and murine monoclonal antibodies and Fab/Fv fragments thereof as well as mouse/human chimeric antibodies were employed. While, lgG 1, 2 and 4 antibodies with identical specificities (affinity constants) have i

A family history of fracture and fracture risk: a meta-analysis

The aims of the present study were to determine whether a parental history of any fracture or hip fracture specifically are significant risk factors for future fracture in an international setting, and to explore the effects of age, sex and bone mineral density (BMD) on this risk. We studied 34,928 men and women from seven prospectively studied cohorts followed for 134,374 person-years. The cohort

Brief admission by self-referral for adolescents who self-harm : discourses on involvement and responsibility among parents and other significant adults

BACKGROUND: Brief Admission by self-referral (BA) was implemented in 2018 in Swedish child and adolescent psychiatric (CAP) inpatient care. This intervention empowers adolescents to self-admit at their own request for brief periods to prevent self-harm and suicidal crisis. As BA enhances healthcare user autonomy, it is a timely intervention to consider with the emerging human rights discourse and

Loss of inhibition in ipsilateral somatosensory areas following altered afferent nerve signaling from the hand

Cutaneous stimulation of the hand results in increased neural activity in the contralateral primary somatosensory cortex (S1) in humans, whereas an inhibition of neurons is seen in the ipsilateral S1.The aim of this study was to assess changes in neural activity in the S1 bilaterally, with a focus on the ipsilateral hemisphere, following altered afferent nerve signaling from the hand. Three cohort

Measuring childhood cancer late effects : evidence of a healthy survivor effect

Introduction: Given considerable focus on health outcomes among childhood cancer survivors, we aimed to explore whether survivor bias is apparent during long-term follow-up of childhood cancer survivors. Methods: We identified all 1-year survivors of cancer diagnosed before 20 years of age in Denmark, Finland, Iceland, and Sweden. From the general population, we randomly sampled a comparison cohor

Bivalirudin versus heparin monotherapy in non-ST-segment elevation myocardial infarction

BACKGROUND: The optimal anti-coagulation strategy for patients with non-ST-elevation myocardial infarction treated with percutaneous coronary intervention is unclear in contemporary clinical practice of radial access and potent P2Y12-inhibitors. The aim of this study was to investigate whether bivalirudin was superior to heparin monotherapy in patients with non-ST-elevation myocardial infarction w

Flickor och pojkar i barnbokens värld: en studie om genus

The purpose with this qualitative text analysis was to study how the sex roles of children are presented in children's books published in 2004 in comparison with children's books published 1972-74. The focus was to find patterns and differences. The study embraces eight books intended for children aged 5-9. The main results of the study showed that the girls were described to have a great

Han, Tarzan; Hon, Jane?: En studie om skillnader mellan pojkar och flickor i utredningsarbete på en socialförvaltning

The purpose of this essay was to examine whether there were any differences in social workers way of investigating boys and girls, age 13-15. The main questions we wanted to answer were; which were the factors that the social workers focused on? Did the investigations lead to a measure and if so, which one? How were risk and protection factors described and ana-lysed? To answer our questions we r

Verktyg för hantering av processförändringar

This report describes how you can create an application that uses Microsoft’s technologies, Windows Workflow Foundation, Windows Forms and Windows Presentation Foundation, to create and edit workflows. Companies have all sorts of processes, which support their business. Like create an E-mailaccount in the company’s network. When companies reorganize or streamline their business the processes needs

An evaluation of two well insulated roof structures

Moisture is considered to be a severe problem in outdoor ventilated attics in Sweden today (2015), and almost 60% of all single family houses and 10% of all multifamily houses have problems with mould growth correlated to moisture in the attics. Increased insulation layers and new heating systems in combination with a more humid climate have increased the risk of such problems. This study has focu

Evolution of Major Histocompatibility Complex (MHC) Genes in Songbirds

The major histocompatibility complex (MHC) is a membrane protein group of central importance in the immune system. It is divided into two main classes, class I and class II. The MHCs are highly polymorphic which is believed to be indication of trans-species polymorphism (TSP). There is TSP when an allele is maintained in two species through a speciation event. The songbirds that I study here belon

Metal Extraction from Mine Wastewater Sludge - Leaching with ammonia and sulfuric acid

Increasing demand for metals might lead to extraction of metals from materials, previously, thought of as waste. A letter by the Swedish Environmental Protection Agency and Geological Survey of Sweden from 2017 encouraged new and innovative waste treatments as well as recycling of waste produced in association with mining. The conventional treatment of acid mine wastewater creates large volumes of

The Perception of Intonation in Japanese Sentence Types by Swedish Speakers : Wh-Questions, Yes/No-Questions and Declaratives

This study is concerned with the topic of sentence-final intonation in wh-questions, yes/no- questions and declaratives. The aim of the study is to investigate whether native speakers of Swedish can recognize these sentence types in standard Japanese by listening to the intonation alone. In addition, whether exposure to the language affects the ability to distinguish these sentence types is invest

Finns Mozarteffekten? Ett experiment om inverkan av klassisk musik på matematisk problemlösning

Syftet med den här kvantitativa studien är att undersöka om Mozart-effekten har någon inverkan på matematisk problemlösningsförmåga, self-efficacy och arousal och om dessa tre variabler kan manipuleras med Mozarts sonata för två pianon. Mozarts sonata K448 är den oberoende variabeln. Matematiska resultat, vakenhetsgrad och Self efficacy undersöktes som beroende variabler. Studiens population var sThe aim of this quantitative research study was to investigate if the Mozarteffect had any impact on mathematical problem-solving ability, self-efficacy and arousal, and if these three variables can be manipulated with Mozarts sonata for 2 pianos. Mozart’s sonata K448 is the independent variable. Mathematical results, arousal and self-efficacy were investigated as dependent variables. The populati

Det var inget hotell de hamnade på : ungas upplevelser av psykiatrisk tvångsvård

The purpose of this study was to examine young people’s experiences of compulsory institutional care in psychiatric clinics. The study was conducted by a qualitative content analysis in which I studied six different blogs on the internet that were selected through a non-random selection. The analysis is based on symbolic interactionism, Goffman´s theory about total institutions and the powerconcep

Exploring Regioselective 5N-acylation of Neuraminic acid

In this project, a regioselective method to deprotect and acylate the amide on C5 of sialic acid is explored. Sialic acid is one of the most complex monosaccharides and is an important ligand in many higher organisms in intercellular cell communication. The most prominent example is related to the immune system. Sialic acids are attached as the terminal carbohydrate on cell surface glycans, which

Optimization-Based Geometry Correction Of Blood Flow CFD Simulations Using 4D-Flow Data

Kan man kombinera Magnetisk Resonanstomografi, mer k ̈ant som MRI, Magnetic Resonance Imaging, med geometrioptimering av fl ̈odessimuleringar f ̈or att f ̊a fram mer detaljrika bilder av blodfl ̈odet? I denna studiehar vi arbetat med att vidareutveckla ett verktyg f ̈or att ̈oka uppl ̈osningen p ̊a tredimensionella bilder av blodk ̈arl i kroppen. Ett syfte med den h ̈ar tekniken ̈ar att ge l ̈akar4D-flow is a powerful tool capable of capturing 3-dimensional, time-resolved flow measurements of blood flow in the body. Their current use is limited by resolution and scan times. A proposed solution is to use Simulation Based Imaging (SBI). This combines lower resolution 4D-flow scans with CFD simulations to improve resolution and reduce scan times. Previous work has focused on inlet and outlet

Machinability Analysis of Grey Cast Iron

Grey Cast iron is an Iron Carbon alloy and is known for its wide range of applications in manufacturing industry. It contains inclusions such as Manganese, silicon, nickel, vanadium and copper. Traces of impurities such as sulphur and phosphorous are also present which is one of the factors affecting Machinability leading to unpredictable process behavior. This Master’s degree thesis is an Indust