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Brominated flame retardants and organochlorines in the European environment using great tit eggs as a biomonitoring tool

Large-scale studies are essential to assess the emission patterns and spatial distribution of organohalogenated pollutants (OHPs) in the environment. Bird eggs have several advantages compared to other environmental media which have previously been used to map the distribution of OHPs. In this study, large-scale geographical variation in the occurrence of OHPs, such as polychlorinated biphenyls (P

Increased expression of vasoactive intestinal polypeptide in cultured myenteric neurons from adult rat small intestine.

Adult neurons possess the ability to adapt to a changing environment. Loss of target-derived neurotrophic factors due to axotomy or isolation by culturing is known to induce changes in neuropeptide expression in several types of peripheral neurons. The aim of the present study was to investigate changes in the expression of vasoactive intestinal polypeptide (VIP) and nitric oxide synthase (NOS) in

Quantitative and qualitative evaluation of plasma and urine alpha(1)-microglobulin in healthy donors and patients with different haemolytic disorders and haemochromatosis

Background: The haem-binding protein alpha(1)-microglobulin (alpha(1)m) is involved in protection against oxidative damage induced by extracellular haem/haemoglobin. A carboxy-terminally truncated form of alpha(1)m (t-alpha(1)m), formed by reactions with haemoglobin, degrades haem into a yellow-brown chromophore linked to the protein. The aim of this work was to investigate if t-alpha(1) in is pre

End-of-life decision making in Europe and Australia - A physician survey

Background: The frequencies with which physicians make different medical end-of-life decisions (ELDs) may differ between countries, but comparison between countries has been difficult owing to the use of dissimilar research methods. Methods: A written questionnaire was sent to a random sample of physicians from 9 specialties in 6 European countries and Australia to investigate possible differences

Occupational exposure to organic dust, microorganisms, endotoxin and peptidoglycan among plants processing workers in Poland

The objective of present work was to determine and compare the components of bioaerosol in several sectors of plant processing industries. The Study was conducted in 10 Facilities engaged in herb and grain processing, flax threshing, grain storing, baking, and cereals production. The air samples were taken on glass fibre litters with an AS-50 sampler. We determined the concentrations of airborne m

Risk factors for cardiovascular malformation - a study based on prospectively collected data

Objectives The aim of this study was to identify risk factors for cardiovascular malformation. Methods In a case-referent study prospectively collected data were obtained from original medical records. The study included 277 woman who had infants with a severe cardiac defect, and for each case two referents (medical records study) were included. Data on parental age, maternal reproductive history,

Contact allergy to common ingredients in hair dyes

Background p-Phenylenediamine (PPD) is the primary patch test screening agent for hair dye contact allergy, and approximately 100 different hair dye chemicals are allowed. Objectives To examine whether PPD is an optimal screening agent for diagnosing hair dye allergy or whether other clinically important sensitizers exist. Methods Two thousand nine hundred and thirty-nine consecutive patients in 1

Fiber length and shape-dependent differences in hepatic nanomaterial localization in mice following pulmonary exposure

Background: Inhaled nanomaterials can translocate from the lungs into systemic circulation and reach the liver, which is the main secondary organ for nanomaterial uptake, potentially causing adverse effects. Understanding how inhaled nanomaterials localize within liver tissue is important for understanding their clearance mechanisms and potential toxicity. Previous in vivo studies have primarily f

Det du inte vet mår du dåligt av: En experimentell studie av uppmärksamhets bias hos ångestindivider

Syftet med den här studien var att undersöka ångests påverkan på uppmärksamhet. Deltagare med högt skattad ångest förväntades skilja sig åt från deltagare med lågt skattad ångest gällande deras uppmärksamhet. Deltagare förväntades skapa ett implicit minne för kombinationen av ansikten som presenterades för dem i experimentet. Ett modifierat dote probe test användes för att undersöka vad försöksperThe purpose of this study was to examine attentional biases in anxiety. Participants with high self-rated anxiety were predicted to differ in their attention compared to participants with low self-rated anxiety. Participants were predicted to have an implicit memory for the combination of faces that were used in the study. A modified dot probe task was used to examine high and low social and/or tr

Implications of AMBRA1 in phenotype switching & MAPK inhibitors response in melanoma

Att överlista melanom och dess förmåga att anpassa sig Melanom är en typ av cancer som har en fantastisk förmåga att anpassa sig till sin miljö och omständigheterna. Det har länge verkat som att melanom har en förmåga att inte bara överleva, utan också frodas i vad man än utsätter dom för, inklusive de vanligaste cancerbehandlingarna. Därför har man behövt tänka utanför ramarna för att hitta andrAdvanced melanoma has for long been associated with poor prognosis. Recent advance- ments have improved outcomes; however, many challenges are yet to be overcome. Targeted therapy has in recent years been a good option for patients. Despite positive early responses to the treatment, tumours often grow resistant to these therapies over time rendering them ineffective. The development of resistance

The impact of local symptoms on health-related quality of life in vulvar cancer survivors—A nationwide prospective study

Introduction: Vulvar cancer may cause serious local symptoms that may impact negatively on the woman's health-related quality of life (HRQOL). However, knowledge about the prevalence of vulvar and lymphedema symptoms at diagnosis and during follow-up is limited. The aim of this study was to evaluate the longitudinal development of vulvar and lymphedema symptoms as well as the trajectory of HRQOL i

Patient Reflections on Participation in a Randomised Controlled Multimodal Prehabilitation Trial Before Ventral Hernia Repair

Background: The aim was to explore patients’ reflections related to their choice of participating or not in a multimodal prehabilitation randomised controlled trial (RCT) in relation to minor surgery. Methods: A qualitative study with 22 semi-structured in-depth interviews on patients awaiting ventral hernia repair was conducted between March and May 2024 and reported according to the COREQ guidel

Carbohydrate-restricted diets in diabetes and the irritable bowel syndrome. Effects on symptoms, inflammation and microbiota.

This doctoral thesis explores the effects of carbohydrate(CHO)-restricted diets on symptoms and disease-related variables in type 2 diabetes mellitus (T2DM) and the irritable bowel syndrome (IBS). Aims were to examine the effects of (I) the moderately-low CHO Okinawan-based Nordic diet on anthropometry and metabolism and microbiota-related, inflammatory, and cognitive parameters in T2DM, and (II)

Segregation dynamics of a Pd-Ag surface during CO oxidation investigated by NAP-XPS

The dynamic changes in composition in the near-surface region of a Pd75%Ag25%(100) single crystal were monitored using near-ambient pressure x-ray photoelectron spectroscopy (NAP-XPS) during CO oxidation under oxygen rich conditions at a total pressure of 1.1 mbar. Six CO oxidation temperature cycles were investigated at different heating rates and maximum temperatures of 450 °C or 600 °C. It was

The GALAH survey : Characterization of emission-line stars with spectral modelling using autoencoders

We present a neural network autoencoder structure that is able to extract essential latent spectral features from observed spectra and then reconstruct a spectrum from those features. Because of the training with a set of unpeculiar spectra, the network is able to reproduce a spectrum of high signal-to-noise ratio that does not show any spectral peculiarities, even if they are present in an observ

Do Assistive Products Enhance or Equalize Opportunities? A Comparison of Capability across Persons with Impairments Using and Not Using Assistive Products and Persons without Impairments in Bangladesh

Aiming to compare capability across persons with impairments using and not using assistive products and persons without impairments in Bangladesh for 16 different functionings, we contrast two sets of self-reported cross-sectional data from eight districts of Bangladesh: (i) data from persons with hearing impairment not using hearing aids, persons with hearing impairment using hearing aids and per

Common variants in breast cancer risk loci predispose to distinct tumor subtypes

Background: Genome-wide association studies (GWAS) have identified multiple common breast cancer susceptibility variants. Many of these variants have differential associations by estrogen receptor (ER) status, but how these variants relate with other tumor features and intrinsic molecular subtypes is unclear. Methods: Among 106,571 invasive breast cancer cases and 95,762 controls of European ances

Prevalence of Facial Pain and Headache in Sweden

Aims: To compare the prevalence of facial pain and headache across various regions in Sweden. Methods: This study involved a comparison of cross-sectional questionnaire studies over a period of 10 years including 128,193 individuals and assessed facial pain, pain on function, and headache. Participants included (1) all Public Dental Service patients aged 16 to 90 years in Västerbotten (n = 57,283)