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Objective: We evaluated whether patient-reported outcome trajectories (i.e., changes over time) differed by intraoperative compartmental cartilage lesion pattern over 4–6 years following arthroscopic meniscal surgery. Methods: In this ancillary study of the Knee Arthroscopy Cohort Southern Denmark cohort, we intraoperatively categorized cartilage lesions as isolated patellofemoral, isolated tibiof

Som en del av ett projekt på Samhällsvetenskapliga fakulteten vid Lunds universitet har Samhällsvetenskapliga fakultetens biblioteks (Sambibs) personal gått en kurs om iPads och appar. För att höja hela personalgruppens kompetens gick samtliga bibliotekarier kursen. Deltagarnas erfarenheter och åsikter dokumenterades i den blogg där kursuppgifterna publicerades och alla fyllde också i enkäter. Kur

Heat exchanger network pinch sets the limitations of heat recovery for existing network topologies. Improving the heat recovery within a pinched-network is independent of the areas of individual exchangers present in the network, rather the topology of the network must be altered. Such a change in the topology can be very capital intensive and in many cases seems not easy to implement. This resear

Objectives: Few studies have examined how lifestyle factors affect functional gastrointestinal disorders. The aim of this study was to see if leisure time physical inactivity, dietary habits or body mass index (BMI) were associated with increased risk of functional abdominal pain, functional bloating, functional constipation or functional diarrhea. Methods and materials: This study was based on a

Eleven new baddeleyite U–Pb crystallisation ages and associated whole-rock geochemistry on NE–NNE-trending tholeiitic dykes cutting across the north-eastern corner of the Archaean Kaapvaal Craton, the overlying Transvaal basin and the Bushveld and Phalaborwa igneous complexes collectively define a 1875–1835 Ma Black Hills Dyke Swarm (BHDS). Dyke ages do not discriminate between dyke trends or geog

Background: Colorectal cancer is one of the most common types of cancers worldwide. Recent studies have identified cancer-initiating cells (CICs) as a subgroup of replication-competent cells in the development of colorectal cancer. Although it is understood that an inflammation-rich tumor microenvironment presumably supports CIC functions, the contributory factors are not very well defined. The pr

OBJECTIVE: Adenocarcinoma of the appendix is less than 0.5% of all gastrointestinal cancers. The aim of this study was to analyse the incidence, symptoms, pathology and treatment of appendiceal adenocarcinoma in a well defined cohort as well as the prognosis of the patients.MATERIALS AND METHODS: This is a retrospective study on all patients diagnosed with adenocarcinoma of the appendix in Iceland

Background/Objectives A cascade of gene activations under the control of Notch signalling is required during T-cell specification, when T-cell precursors gradually lose the potential to undertake other fates and become fully committed to the T-cell lineage.We elucidate how the gene/protein dynamics for a core transcriptional module governs this important process by computational means. Methods We

Introduction: Regular physical activity is associated with longevity in adults receiving hemodialysis, but it is uncertain whether this association varies by causal pathways (cardiovascular and noncardiovascular). Methods: DIET-HD was a prospective, multinational study of adults undergoing hemodialysis across Europe and Argentina. We classified participants as physically inactive, occasionally act

Purpose: It is common for radiation oncologists (ROs) today to have a mixed arsenal of radiotherapy treatment modalities at their disposal. To optimize a clinic's use of its different treatment modalities, while at the same time giving every patient an optimal treatment, is not a trivial task. The purpose of this study was to give ROs a tool to choose between available modalities. This would help

To evaluate the diagnostic yield of the ECG criteria for ST-elevation myocardial infarction in a large cohort of emergency department chest pain patients, and to determine whether extended ECG criteria or reciprocal ST depression can improve accuracy. Design: Observational, register-based diagnostic study on the accuracy of ECG criteria for ST-elevation myocardial infarction. Between Jan 2010 and

Introduction: Ischemic spinal cord injury (SCI) is a serious complication of complex aortic repair. Prophylactic cerebrospinal fluid (CSF) drainage, used to decrease lumbar cerebrospinal fluid (CSF) pressure, enables monitoring of CSF biomarkers that may aid in detecting impending SCI. We hypothesized that biomarkers, previously evaluated in traumatic SCI and brain injury, would be altered in CSF

Assessing the optimal placement and design of a large‐scale high temperature energy storage system in crystalline bedrock is a challenging task. This study applies and evaluates various methods and strategies for pre‐site investigation for a potential high temperature borehole thermal energy storage (HT‐BTES) system at Linköping in Sweden. The storage is required to shift approximately 70 GWh of e

This article offers the first empirical and cross‐national analysis of citizens’ views about the democratic importance of the public sphere. We first identify three normative functions that public spheres are expected to perform in representative democracies: they provide voice to alternative perspectives, they empower citizens to criticise political authorities and they disseminate information on

BACKGROUND: Nosocomial outbreaks of coronavirus disease 2019 (COVID-19) can have devastating consequences from both a resource cost and patient healthcare perspective. Relying on reverse transcription-polymerase chain reaction (RT-PCR) for identifying infected individuals may result in missed cases. Screening for antibodies after an outbreak can help to find missed cases and better illuminate rout

BACKGROUND: Improvements in surgery, imaging, adjuvant treatment, and management of metastatic disease have led to modification of previous approaches regarding the risk of recurrence and prognosis in colorectal cancer. The aims of this study were to map patterns, risk factors, and the possibility of curative treatment of recurrent colorectal cancer in a multimodal setting. METHODS: This was a coh

Human mitochondrial dihydroorotate dehydrogenase (the fourth enzyme of pyrimidine de novo synthesis) has been overproduced by means of a recombinant baculovirus that contained the human cDNA fragment for this protein. After virus infection and protein expression in Trichoplusia ni cells (BTI-Tn-5B1-4), the subcellular distribution of the recombinant dihydroorotate dehydrogenase was determined by t

Aims. The Landé g-factor is an important parameter in astrophysical spectropolarimetry, used to characterize the response of a line to a given value of the magnetic field. The purpose of this paper is to present accurate Landé g-factors for states in B II, C I-IV, Al I-II, Si I-IV, P II, S II, Cl III, Ar IV, Ca I, Ti II, Zr III, and Sn II. Methods. The multiconfiguration Dirac-Hartree-Fock and rel

The structures of the solvated copper(II) ion in water and nine organic oxygen donor solvents with similar electron-pair donor ability, but with different space-demanding properties at coordination, have been studied by EXAFS. N,N′-Dimethylpropyleneurea and N,N,N′,N′-tetramethylurea are sufficiently space demanding at coordination to make the axial positions not accessible, resulting in square-pla

Cell-mediated immune suppression may play an important role in lung carcinogenesis. We investigated the associations for circulating levels of tryptophan, kynurenine, kynurenine:tryptophan ratio (KTR), quinolinic acid (QA) and neopterin as markers of immune regulation and inflammation with lung cancer risk in 5,364 smoking-matched case–control pairs from 20 prospective cohorts included in the inte