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The Klotho (KL) gene is involved in phosphate homeostasis. Polymorphisms in this gene have been reported to be associated with the risk of cardiovascular disease. Here we used computational tools to predict the damage-associated single nucleotide polymorphisms (SNPs) in the human KL gene. We further investigated the association of SNPs in the KL gene and mortality in the Swedish multicenter prospe

Aims. The Landé g-factor is an important parameter in astrophysical spectropolarimetry, used to characterize the response of a line to a given value of the magnetic field. The purpose of this paper is to present accurate Landé g-factors for states in B II, C I-IV, Al I-II, Si I-IV, P II, S II, Cl III, Ar IV, Ca I, Ti II, Zr III, and Sn II. Methods. The multiconfiguration Dirac-Hartree-Fock and rel

The structures of the solvated copper(II) ion in water and nine organic oxygen donor solvents with similar electron-pair donor ability, but with different space-demanding properties at coordination, have been studied by EXAFS. N,N′-Dimethylpropyleneurea and N,N,N′,N′-tetramethylurea are sufficiently space demanding at coordination to make the axial positions not accessible, resulting in square-pla

Litters of BB rats with an expected high and low incidence of insulin-dependent diabetes were followed from weaning until the age of about 140 days. Islet cell surface antibodies (ICSA) and lymphocyte antibodies (LA) were determined in a radioligand assay with fixed rat insulinoma (RIN 5F) cells, an insulin-secreting cell line, or spleen lymphocytes. In the low-incidence litter, 2 out of 14 rats h

In order to reduce the environmental impacts within the building sector, recycling of building materials is on the increase. Projects are carried out on several levels and are often well analysed regarding the economic consequences; however, the actual environmental effects are rarely studied. This paper presents a study of the environmental impacts due to a building from 1997 with a large proport

Different methods to separate quark jets from gluon jets have been investigated and tested on data from the DELPHI experiment. A test sample of gluon jets was selected from $bar{b}g$ threejet events where the two b-jets had been identified using a lifetime tag and a quark jet sample was obtained from $qar{q}gamma$ events where the photon was required to have a high energy and to be well separated

The purpose of the study is to offer an interpretation of surrealism as lived experience or, more exactly, an interpretation of the ways in which the Surrealists themselves respond to and conceive of this experience. Thus, emphasis is put on surrealism as event and process, not as a historically limited phenomenon. The prime source of knowledge about this kind of experience, however, remains Surre

My dissertation studies the frequently mentioned but never fully explored affinities between the writings of Juan Carlos Onetti and Juan José Saer. From the very beginning of their writing careers, both authors relate writing and narrating to an elusive search for meaning—in life and stories. Consequently, the scene of storytelling is of the utmost importance; how, when, by and to whom, and indeed

This thesis deals with Chiral Perturbation Theory (ChPT), an effective field theory for the strong force used to describe meson interactions. The work done can be split in two parts. The first one is on ChPT in its standard formulation. This theory has been very successful so far in describing low energetic processes. However, it is still not entirely clear how much it can be trusted for precision

A novel approach in molecular design is presented, where in vivo formed complementarity determining regions (CDR) from antibody genes were shuffled into a specific framework region. A synthetic gene library of soluble VH-fragments was created and the complexity of the library was determined by sequencing. The synthetic genes were diverse and contained random combinations of CDR from different germ

Possibilities to develop human monoclonal antibody specificities have recently been much facilitated by improvements of human hybridoma technology but even more so by the emerging phage-display technique. However, until recently very little has been known about the characteristics at the molecular level of the induced, T cell-dependent human antibody response, frequently targeted by these techniqu

Objectives: Audiologists provide professional contact and support between appointments to clients with hearing impairment using telephone and e-mail, but more advanced and flexible technological platforms are also possible. The present study aimed to evaluate the clinical application of an Internet-based support system for audiologists and their first-time hearing aid clients. Design: An Internet-

The concentrations of cartilage proteoglycan (aggrecan), stromelysin-1, tissue inhibitor of metalloproteinases-1 (TIMP-1) and procollagen II C-propeptide in knee joint fluid and the levels of aggrecan, hyaluronan and keratan sulfate in serum were measured before and after exercise in 33 healthy athletes. The samples before exercise were obtained after 24 h rest from running or soccer and the sampl

BACKGROUND: Cannabinoid receptor (CB)-mediated functions may be involved in the regulation of bladder function, but information on endocannabinoid signals during micturition is scarce. OBJECTIVE: Investigate the expression of the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) in human, rat, and mouse bladders and study the effects of inhibition of FAAH during urodynamics in awa

PURPOSE: Irradiation inflicts acute injuries to the intestinal mucosa with rapid apoptosis induction and subsequent reduction in epithelial surface area. It may therefore be assumed that the intestinal barrier function is affected. The aim of this study was to compare the mucosal permeability in irradiated rectum and nonirradiated sigmoid colon from patients subjected to radiation therapy before s

Detta examensarbete var en del i ett forskningsprojekt som utfördes vid avdelningen för maskinkonstruktion vid Lunds tekniska högskola och gick ut på att studera hur metodiken kring produktutveckling används hos ett antal företag i praktiken och jämföra detta med metodiken från litteraturen och det som lärs ut vid Lunds tekniska högskola, för att identifiera brister i modellerna och fungera som etThis Master´s Thesis is part of a larger research project carried out at the Division of Machine Design, Department of Design Science, LTH, and is about studying the product development methodologies applied in the industry and compare these to the methodologies described in the literature and taught at LTH. The first part of the assignment consisted in studying the existing methodologies about pr

Background: Concern was raised within the International Contact Dermatitis Research Group (ICDRG) regarding the scoring of weak allergic versus doubtful patch test reactions. Objective: To investigate the degree of uniformity in patch test reading. Methods: Five series of fictive contact dermatitis cases were written up by the study organizer and presented to expert participants. Each series was s