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Aims: The REPRISE IIE trial aimed to evaluate outcomes following transcatheter aortic valve implantation of the fully repositionable and retrievable LOTUS valve with a unique seal designed to minimise paravalvular leak (PVL). Methods and results: This prospective, multicentre study enrolled 250 patients with severe aortic stenosis considered high-risk for surgery by a multidisciplinary Heart Team.

Introduction: Oral contraceptives (OC) have been shown to give a transient increased breast cancer risk. However, studies on breast cancer survival after OC use are sparse and conflicting.Aim: The aim of this study was to examine previous use of OC in relation to survival after breast cancer diagnosis.Methods: Data was collected from Malmö Diet and Cancer Study, with baseline examinations between

In this work, 3-point bending tests and micro-hardness measurements were performed on pure tungsten irradiated with high-energy protons and spallation neutrons in a target of the Swiss Spallation Neutron Source (SINQ). The specimens were irradiated to doses in the range of 1.3–3.5 dpa, with 37–140 appm He, at temperatures between 75 and 110 °C. During 3-point bending tests performed at temperature

Objectives: Inclusion body myositis is characterized by inflammatory and degenerative changes, but the temporal relation of these events is unknown. Materials and Methods: In nineteen patients with inclusion body myositis, muscle strength was correlated with inflammatory and degenerative findings on magnetic resonance imaging (MRI) and in muscle biopsies in three different muscles (tibialis anteri

Purpose: Chest radiographs from 3 digital systems - 2 based on luminescent phosphors and one on selenium - and a conventional film-screen system were evaluated and compared. Material and Methods: Computed radiography (CR) has for the past years been dominated by a single manufacturer, but now several systems have been marketed. Using a chest phantom and, as test objects, 2 simulated tumours for th

PURPOSE: Amacrine cells expressing nitric oxide synthase (NOS) are seen in normal retinas and retinal grafts to extend long processes, which can be followed for long distances. Taking advantage of the morphologic features of these cells, the present study examined whether graft-host connections involve cells capable of producing nitric oxide, a recognized retinal neuromodulatory compound.METHODS:

Abstract Conclusion: In this physiological study subjects with Meniere's disease (MD) had high resistance to opening of the eustachian tube (ET) in three of four provocation tests. These subjects can be exposed to pressure deviations in the middle ear (ME) above their equalizing capacity. Transmission of the pressure deviations to the inner ear fluids and influence of the symptoms of MD are feasib

BACKGROUND: There is mounting evidence that children born after in vitro fertilization (IVF) run an increased risk of neurological complications and notably cerebral palsy. Whether developmental disturbances occur more often than expected is debated. AIM: To investigate the risk for ADHD in children conceived after IVF. METHODS: Children conceived after IVF and born between 1982 and 2005 were iden

Perturbation in the expression and signaling pathways of vascular endothelial growth factor (VEGF) has been linked to pathogenesis of hematologic malignancies. We investigated the expression and clinical importance of VEGF and two of its receptors, VEGFR-1 and VEGFR-2, in childhood precursor B-cell acute lymphoblastic leukemia (pre-B ALL) by using immunohistochemistry. These angiogenic proteins we

The collective effective radiation dose to the population is increasing due to a higher use of computerised tomography. SharpView AB, Linköping, Sweden, has developed an adaptive non-linear post-processing image filtration that may enable the use of lower radiation doses. The present study assessed if a lower dose with image filtration had the same image quality as a higher dose without the filter

Medieval round churches are often seen as riddles in need of special explanation. Deviant architecture has been explained by three major theories – fortification, multi-functionality and symbolic copying. However, I claim that the round churches were normal except for their elite context and extraordinary plan. I then argue, that the elite consciously choose a “conspicuous architecture”, to use a

Objective: Catheter-associated urinary tract infection (CAUTI) is the most common healthcare-associated infection. The primary aim of this study was to investigate whether the use of a silicone catheter coated with an ultrathin layer of a combination of the noble metals gold, palladium and silver (BIP™–silicone catheter) could reduce the incidence of CAUTI and antibiotic prescription compared with

OBJECTIVE: To develop a method enabling capillary density to be determined rapidly and accurately in patients with systemic sclerosis.METHOD: Capillary density was determined in 11 controls and 22 patients: 5 with diffuse cutaneous systemic sclerosis (dSSc), 12 with limited cutaneous systemic sclerosis (lSSc), two with suspected systemic sclerosis (suspSSc), 2 with sclerodermatomyositis, and one w

Objective: While beta(2)-agonists for the acute treatment of preterm labour unequivocally reduce the odds of delivery within 48 hand 7 days, they have been associated with substantial maternal and fetal side effects. We aimed to compare side effect profiles of beta(2)-agonist tocolytics. Study design: Pragmatic comparison of ritodrine, salbutamol and terbutaline from re-analysis of data obtained w

INTRODUCTION: Analogues of vitamin A have been shown to influence growth of malignant tissue, such as pancreatic cancer. AIMS: To study the expression of retinoic acid receptors (RAR) in pancreatic cancer cells and the effect of three different retinoids on the cell number in vitro were studied. METHODOLOGY: Cell lines were established from 13 patients who underwent surgery for pancreatic adenocar

Purpose: To study the incidence of aphakia after cataract surgery, the surgical complications that can lead to it, and the visual outcome. Setting: Six community-run eye clinics participating in the Swedish National Cataract Register. Methods: Data on cataract extractions were collected prospectively from 1997 through 2001. The data also covered the type of surgery and type of intraocular lens, in

Extensive measurements of soil surface (including vegetation cover) CO2 efflux were carried out on 80 positions at four different forest sites (Sweden, Germany, Czech Republic and Italy) using a closed dynamic chamber technique. The period of measurement was 4-5 consecutive days per site. Two approaches were used to analyze the measured data, the Q(10) parameter and the Arrhenius relationship. Bas

Drawing on Freire, this article elaborates on how pictures and artefacts benefit processes of 'prise de conscience' and 'conscientization' among those with powerful voices. Wor(l)d-making was unfolded in the Swedish think-and-do tank, 'the Smithy', emphasizing the intrinsically political nature of promoting 'societal entrepreneurship' (SE). New words for SE were formulated and a more inclusive wor

The aim of this study was to assess prospectively the long-term outcome in a representative sample of teenage-onset anorexia nervosa (AN) in respect of psychiatric disorders and overall outcome. Fifty-one AN cases, recruited by community screening, with a mean age of onset of 14 years, was contrasted with 51 matched comparison cases at a mean age of 24 years (10 years after AN onset). All 102 case