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A novel approach in molecular design is presented, where in vivo formed complementarity determining regions (CDR) from antibody genes were shuffled into a specific framework region. A synthetic gene library of soluble VH-fragments was created and the complexity of the library was determined by sequencing. The synthetic genes were diverse and contained random combinations of CDR from different germ

Clinical education is a significant part of nursing education on all levels of education. A lot of effort is made by educational providers to prepare the students for their clinical placement (Levett-Jones et al., 2015). At best, this is a shared enterprise, involving representatives from the profession in creating a useful clinical placement for the students. However, the strain on clinical nurse

All colonies of the fungus-growing termite Macrotermes natalensis studied so far are associated with a single genetically variable lineage of Termitomyces symbionts. Such limited genetic variation of symbionts and the absence of sexual fruiting bodies (mushrooms) on M. natalensis mounds would be compatible with clonal vertical transmission, as is known to occur in Macrotermes bellicosus. We invest

Theories of agrarian transformations and modernization, 7,5 ECTS PhD course within the National program for research education in Human geography Fall 2019 Course coordinators: Lowe Börjeson, Department of Human Geography, Stockholm University and Don Mitchell, Department of Social and Economic Geography, Uppsala University. Other teachers: Chris de Bont, researcher, Department of Human Geography,

https://www.keg.lu.se/sites/keg.lu.se/files/agrarian_transformations_syllabus_v190501.pdf - 2026-05-07

Syfte: Syftet var att undersöka huruvida svensktalande barn med språkstörning (developmental language disorder, DLD) uppvisar en preferens för rak SV-ordföljd, undersöka hur distributionen av rak och omvänd XVS-ordföljd förändras över tid, och jämföra antalet förekomster av den ogrammatiska XSV-strukturen hos barnen med språkstörning jämfört med barn med typisk språkutveckling. Metod: OrtografiskaPurpose: The purpose was to investigate whether Swedish children with developmental language disorder (DLD) show a preference for canonical SV-word order, investigate how the distribution of canonical and non-canonical word order changes over time, and to compare the number of occurrences of the ungrammatical XSV-structure produced by the children with DLD and typically developing peers. Method: O

The determination of acidic pharmaceuticals, such as non-steroidal anti-inflammatory drugs NSAIDs and clofibric acid (metabolite of clofibrate), at low ngL(-1) levels in wastewater requires highly selective and sensitive analytical procedures. The removal of matrix components during sample preparation results in significant benefits towards reducing the matrix effects during LC-MS analysis. Theref

Popular Abstract in Swedish Bakgrund och syfte med avhandlingen Glutenintolerans, celiaki är en av de vanligaste kroniska sjukdomarna bland barn och innebär att man inte tåler gluten, som är ett protein och finns i vete, råg och korn. Tunntarmen har en veckad slemhinna med fingerlika utskott , tarmludd och hela tarmen har en yta på 250 kvadratmeter, vilket är lika stort som en tennisplan. Den stBackground: The prevalence of celiac disease (CD) is estimated to be around 1%, but most CD cases are undiagnosed. Sweden experienced an epidemic of clinically detected celiac disease in children younger than 2 years of age, partly due to changes in infant feeding practices, were the amount of gluten and age at introduction was changed. However, it was not clear if the increase in clinically detec

Studying gene-lifestyle interaction may help to identify lifestyle factors that modify genetic susceptibility and uncover genetic loci exerting important subgroup effects. Adequately powered studies with prospective, unbiased, standardised assessment of key behavioural factors for gene-lifestyle studies are lacking. This case-cohort study aims to investigate how genetic and potentially modifiable

Background: Perioperative stress or discomfort in shoulder arthroplasty (SA) patients can be reduced using more individually tailored patient education and expectation management. Most published studies assess pain and function for the first time at 6 weeks or 3 months. Consequently, there is no thorough understanding of day-to-day recovery trajectories within the first postoperative weeks, hinder

Background: Malassezia yeasts play a role in the pathogenesis of atopic eczema/dermatitis syndrome (AEDS). The revised genus Malassezia includes several species which all are natural habitants of the human skin. In this study, we evaluated the presence of immunoglobulin E (IgE) antibodies to different Malassezia spp. in AEDS patients to allow optimization of the characterization of the IgE antibod

Background: Data suggests that the plasma levels of the liver-specific miR-122-5p might both be a marker of cardiogenic shock and a prognostic marker of out-of-hospital cardiac arrest (OHCA). Our aim was to characterize plasma miR-122-5p at admission after OHCA and to assess the association between miR-122-5p and relevant clinical factors such all-cause mortality and shock at admission after OHCA.

Intolerance of uncertainty (IU), cognitive avoidance (CA), positive beliefs about worry (PBW) and a tendency to view everyday problems as threats, termed negative problem orientation (NPO), are cognitive vulnerabilities associated with symptoms of anxiety and depression in adults, with fewer studies examining all four vulnerabilities in youth. In this study, validated measures of IU, CA, PBW and N

BACKGROUND/OBJECTIVES: Given the risk of a progression, or an undiagnosed endometrial cancer (EC), the treatment of choice is hysterectomy in women with endometrial intraepithelial neoplasia (EIN). The risk of metastatic disease and whether sentinel node (SLN) biopsy should be performed remains unclear. The primary aim of this prospective study was to determine the overall incidence of concurrent

STUDY QUESTION: Can the alleged association between ovarian endometriosis and ovarian carcinoma be substantiated by genetic analysis of endometriosis diagnosed prior to the onset of the carcinoma?SUMMARY ANSWER: The data suggest that ovarian carcinoma does not originate from ovarian endometriosis with a cancer-like genetic profile; however, a common precursor is probable.WHAT IS KNOWN ALREADY: End

Objective: To determine the diagnostic accuracy of prenatal ultrasound in detecting coarctation of the aorta (CoA). Methods: An individual participant data meta-analysis was performed to report on the strength of association and diagnostic accuracy of different ultrasound signs in detecting CoA prenatally. MEDLINE, EMBASE and CINAHL were searched for studies published between January 2000 and Nove

Background: Chronic lung disease (CLD) occurs frequently in preterm infants and is associated with respiratory morbidity. Bronchodilators have the potential effect of dilating small airways with muscle hypertrophy. Increased compliance and tidal volume, and decreased airway resistance, have been documented with the use of bronchodilators in infants with CLD. Therefore, bronchodilators are widely c

OBJECTIVE: To examine whether chickenpox in children below 2 years of age is associated with post-infection changes in growth, morbidity or mortality. METHODS: An outbreak of chickenpox was investigated in Guinea-Bissau. An examination, interview and anthropometry were performed 6 months after the epidemic for a group of children and matched controls whose weight had been measured at the time of t

This thesis deals with two main areas in the field of stochastic inventory theory; ateral transshipments and perishable items. In the first part of this thesis we give an introduction to the field of inventory theory, and discuss some previous literature connected to the research presented in this thesis. In the second part, the original research which defines this thesis is presented in the form

Popular Abstract in Swedish Syftet med avhandlingen är att beskriva och utvärdera en behandlingsmetod, som avser att öka gångförmågan hos lårbensamputerade. Metoden, vilken tidigare inte är prövad för den här gruppen patienter, kombinerar sjukgymnastiska metoder, huvudsakligen använda inom psykiatrin, med vedertagna ortopediska och biomekaniska behandlingsprinciper. Den syftar till att öka kroppsmA gait re-education programme, combining physiotherapy with a psychologically conscious therapeutic approach, was applied to nine unilateral transfemoral amputees, whose amputation was caused by trauma or tumour. The participants trained once a week for a mean 10 months. The median age was 33 years (range 16– 51). They had worn a prosthesis for more than 18 months and had completed conventional re