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Heat differentiated complement factor profiling.

Complement components and their cascade of reactions are important defense mechanisms within both innate and adaptive immunity. Many complement deficient patients still remain undiagnosed because of a lack of high throughput screening tools. Aiming towards neonatal proteome screening for immunodeficiencies, we used a multiplex profiling approach with antibody bead arrays to measure 9 complement pr

Male clasping ability, female polymorphism and sexual conflict: fine-scale elytral morphology as a sexually antagonistic adaptation in female diving beetles

During sexual conflict, males and females are expected to evolve traits and behaviours with a sexually antagonistic function. Recently, sexually antagonistic coevolution was proposed to occur between male and female diving beetles (Dytiscidae). Male diving beetles possess numerous suction cups on their forelegs whereas females commonly have rough structures on their elytra. These rough structures

Temperature, size, reproductive allocation, and life-history evolution in a gregarious caterpillar

The present study aimed to investigate the relationship between growth rate, final mass, and larval development, as well as how this relationship influences reproductive trade-offs, in the context of a gregarious life-style and the need to keep an optimal group size. We use as a model two sympatric populations of the pine processionary moth Thaumetopoea pityocampa, which occur in different seasons

Desalination and Power Plants Together for Water and Peace A Case study of the Gaza-Strip, Palestine

Desalination can be a cost-effective way to produce fresh water and possibly electricity. The Gaza Strip has had a complex hydro-political situation for many years. Gaza is bordered by the Mediterranean in the west, by Israel in the north and east and by Egypt in the south. Water and electricity consumption in the Gaza Strip is expected to increase in the future due to the increasing population.

Development of a web-based customer-oriented interactive virtual environment for mobile phone design

During recent years, mobile phone companies have experienced market-related difficulties that result in increasing competition globally. In an attempt to maintain or increase their market share, enterprises reorganize their resources and employ new technologies to sharpen their competitive edges. Moreover, with the globalization, more and more companies become multi-sited. Efficient and timely col

Analysis of heart rate variability using time-varying frequency bands based on the respiratory frequency

In this paper a methodological approach for the analysis of nonstationary heart rate variability (HRV) signals using time-varying frequency bands based on respiratory frequency is presented. Spectral analysis of HRV is accomplished by means of the Smoothed Pseudo Wigner Ville distribution. Different approaches to the definition of the low frequency (LF) and high frequency (HF) bands are considered

Joseph Beuys : fett och filt : en forskningskritisk essä

Joseph Beuys. Fat and felt. A critical essay. The extremely singular materials fat and felt for use in art, have an entirely dominating role in a long series of Joseph Beuys’ (1921-1986) most important work. They are found both in single works of art as well as in installations and happenings from the beginning of the 1960s and up to the end of the artist’s life. This essay deals with the artist’

European Union funded project on the development of a whole complement deficiency screening ELISA-A story of success and an exceptional manager: Mohamed R. Daha.

A whole complement ELISA-based assay kit, primarily designed to screen for deficiencies in components of the complement system was developed during a European Union grant involving more than a dozen European scientists and a small-medium enterprise company (Wieslab, which later merged into Eurodiagnostica). The consortium was led by Prof. Mohamed R. Daha who had already guided a preceding European

Cellulose Dissolution in an Alkali Based Solvent: Influence of Additives and Pretreatments

The distinction between thermodynamic and kinetics in cellulose dissolution is seldom considered in the literature. Therefore, herein an attempt to discuss this topic and illustrate our hypotheses on the basis of simple experiments was made. It is well-known that cellulose can be dissolved in a aqueous sodium hydroxide (NaOH/H2O) solvent at low temperature but it is here shown that such an alkalin

CCAAT/enhancer binding protein alpha (C/EBP alpha)-induced transdifferentiation of pre-B cells into macrophages involves no overt retrodifferentiation

Earlier work has shown that pre-B cells can be converted into macrophages by the transcription factor CCAAT/enhancer binding protein a at very high frequencies. Using this system, we performed a systematic analysis of whether during transdifferentiation the cells transiently reactivate progenitor-restricted genes or even retrodifferentiate. A transcriptome analysis of transdifferentiating cells sh

Data Processing Has Major Impact on the Outcome of Quantitative Label-Free LC-MS Analysis

High-throughput multiplexed protein quantification using mass spectrometry is steadily increasing in popularity, with the two major techniques being data-dependent acquisition (DDA) and targeted acquisition using selected reaction monitoring (SRM). However, both techniques involve extensive data processing, which can be performed by a multitude of different software solutions. Analysis of quantita

Association between the transmembrane region polymorphism of MHC class I chain related gene-A and type 1 diabetes mellitus in Sweden

Major histocompatibility complex (MHC) class I chain related gene-A (MIC-A) is associated with type 1 diabetes mellitus (T1DM) in other populations. We tested the association of MIC-A gene polymorphism with T1DM in Swedish Caucasians; if it has an age-dependent association; and if the association has an effect on gender. We studied 635 T1DM patients and 503 matched controls in the age group of 0-3

Young stars in the Galactic Centre: a potential intermediate-mass star origin

There has been recent speculation that the cores of intermediate-mass stars stripped of their envelopes by tidal interaction with the supermassive black hole in the Galactic Centre could form a population observationally similar to the so-called Sgr A* cluster or 'S' stars, which have close eccentric orbits around the hole. We model the evolution of such stars, and show that the more luminous end